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Regional white matter and neuropsychological functioning across the adult lifespan.
Biol Psychiatry 2006; 60(5):444-53BP

Abstract

BACKGROUND

The current study utilized magnetic resonance imaging (MRI) to more fully elucidate the relationship among age, regional white matter, and neuropsychological functioning.

METHODS

One hundred ninety-nine neurologically healthy adults received MRI and standardized neuropsychological assessment. MR images were spatially normalized and segmented by tissue type; relative white matter values in each of the four cerebral lobes in each hemisphere were computed. Subjects were divided into Younger (ages 21-30), Middle (ages 31-54), and Older (ages 55-79) age groups.

RESULTS

The Older group had significantly less overall relative white matter than the Middle group, who had significantly less overall relative white matter than the Younger participants (F (2, 193) = 5.42, p = 0.005). Differences in frontal lobe white matter were of largest magnitude, followed by temporal lobe (F (6, 579) = 3.32, p = 0.003). Age and frontal and temporal lobe white matter were primarily associated with performance on neuropsychological tests of executive functioning and memory. Mediational analysis suggested that frontal lobe white matter mediated the relationship between age and performance on tasks of executive functioning and memory.

CONCLUSIONS

The results confirm age-associated decline in frontal and temporal white matter, and age-related cognitive decline in several domains. Decline in neuropsychological functioning is, in part, mediated by a relative age-related reduction in frontal white matter.

Authors+Show Affiliations

Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA. amb2139@columbia.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16616725

Citation

Brickman, Adam M., et al. "Regional White Matter and Neuropsychological Functioning Across the Adult Lifespan." Biological Psychiatry, vol. 60, no. 5, 2006, pp. 444-53.
Brickman AM, Zimmerman ME, Paul RH, et al. Regional white matter and neuropsychological functioning across the adult lifespan. Biol Psychiatry. 2006;60(5):444-53.
Brickman, A. M., Zimmerman, M. E., Paul, R. H., Grieve, S. M., Tate, D. F., Cohen, R. A., ... Gordon, E. (2006). Regional white matter and neuropsychological functioning across the adult lifespan. Biological Psychiatry, 60(5), pp. 444-53.
Brickman AM, et al. Regional White Matter and Neuropsychological Functioning Across the Adult Lifespan. Biol Psychiatry. 2006 Sep 1;60(5):444-53. PubMed PMID: 16616725.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regional white matter and neuropsychological functioning across the adult lifespan. AU - Brickman,Adam M, AU - Zimmerman,Molly E, AU - Paul,Robert H, AU - Grieve,Stuart M, AU - Tate,David F, AU - Cohen,Ronald A, AU - Williams,Leanne M, AU - Clark,C Richard, AU - Gordon,Evian, Y1 - 2006/04/17/ PY - 2005/04/13/received PY - 2006/01/05/revised PY - 2006/01/10/accepted PY - 2006/4/18/pubmed PY - 2006/10/13/medline PY - 2006/4/18/entrez SP - 444 EP - 53 JF - Biological psychiatry JO - Biol. Psychiatry VL - 60 IS - 5 N2 - BACKGROUND: The current study utilized magnetic resonance imaging (MRI) to more fully elucidate the relationship among age, regional white matter, and neuropsychological functioning. METHODS: One hundred ninety-nine neurologically healthy adults received MRI and standardized neuropsychological assessment. MR images were spatially normalized and segmented by tissue type; relative white matter values in each of the four cerebral lobes in each hemisphere were computed. Subjects were divided into Younger (ages 21-30), Middle (ages 31-54), and Older (ages 55-79) age groups. RESULTS: The Older group had significantly less overall relative white matter than the Middle group, who had significantly less overall relative white matter than the Younger participants (F (2, 193) = 5.42, p = 0.005). Differences in frontal lobe white matter were of largest magnitude, followed by temporal lobe (F (6, 579) = 3.32, p = 0.003). Age and frontal and temporal lobe white matter were primarily associated with performance on neuropsychological tests of executive functioning and memory. Mediational analysis suggested that frontal lobe white matter mediated the relationship between age and performance on tasks of executive functioning and memory. CONCLUSIONS: The results confirm age-associated decline in frontal and temporal white matter, and age-related cognitive decline in several domains. Decline in neuropsychological functioning is, in part, mediated by a relative age-related reduction in frontal white matter. SN - 0006-3223 UR - https://www.unboundmedicine.com/medline/citation/16616725/Regional_white_matter_and_neuropsychological_functioning_across_the_adult_lifespan_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-3223(06)00143-0 DB - PRIME DP - Unbound Medicine ER -