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Regional white matter and neuropsychological functioning across the adult lifespan.

Abstract

BACKGROUND

The current study utilized magnetic resonance imaging (MRI) to more fully elucidate the relationship among age, regional white matter, and neuropsychological functioning.

METHODS

One hundred ninety-nine neurologically healthy adults received MRI and standardized neuropsychological assessment. MR images were spatially normalized and segmented by tissue type; relative white matter values in each of the four cerebral lobes in each hemisphere were computed. Subjects were divided into Younger (ages 21-30), Middle (ages 31-54), and Older (ages 55-79) age groups.

RESULTS

The Older group had significantly less overall relative white matter than the Middle group, who had significantly less overall relative white matter than the Younger participants (F (2, 193) = 5.42, p = 0.005). Differences in frontal lobe white matter were of largest magnitude, followed by temporal lobe (F (6, 579) = 3.32, p = 0.003). Age and frontal and temporal lobe white matter were primarily associated with performance on neuropsychological tests of executive functioning and memory. Mediational analysis suggested that frontal lobe white matter mediated the relationship between age and performance on tasks of executive functioning and memory.

CONCLUSIONS

The results confirm age-associated decline in frontal and temporal white matter, and age-related cognitive decline in several domains. Decline in neuropsychological functioning is, in part, mediated by a relative age-related reduction in frontal white matter.

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  • Authors+Show Affiliations

    ,

    Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA. amb2139@columbia.edu

    , , , , , , ,

    Source

    Biological psychiatry 60:5 2006 Sep 01 pg 444-53

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Aging
    Analysis of Variance
    Brain Mapping
    Cerebral Cortex
    Cross-Sectional Studies
    Frontal Lobe
    Functional Laterality
    Humans
    Image Processing, Computer-Assisted
    Magnetic Resonance Imaging
    Middle Aged
    Myelin Sheath
    Neuropsychological Tests
    Occipital Lobe
    Organ Size
    Parietal Lobe
    Reference Values
    Sex Factors
    Temporal Lobe

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    16616725

    Citation

    Brickman, Adam M., et al. "Regional White Matter and Neuropsychological Functioning Across the Adult Lifespan." Biological Psychiatry, vol. 60, no. 5, 2006, pp. 444-53.
    Brickman AM, Zimmerman ME, Paul RH, et al. Regional white matter and neuropsychological functioning across the adult lifespan. Biol Psychiatry. 2006;60(5):444-53.
    Brickman, A. M., Zimmerman, M. E., Paul, R. H., Grieve, S. M., Tate, D. F., Cohen, R. A., ... Gordon, E. (2006). Regional white matter and neuropsychological functioning across the adult lifespan. Biological Psychiatry, 60(5), pp. 444-53.
    Brickman AM, et al. Regional White Matter and Neuropsychological Functioning Across the Adult Lifespan. Biol Psychiatry. 2006 Sep 1;60(5):444-53. PubMed PMID: 16616725.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Regional white matter and neuropsychological functioning across the adult lifespan. AU - Brickman,Adam M, AU - Zimmerman,Molly E, AU - Paul,Robert H, AU - Grieve,Stuart M, AU - Tate,David F, AU - Cohen,Ronald A, AU - Williams,Leanne M, AU - Clark,C Richard, AU - Gordon,Evian, Y1 - 2006/04/17/ PY - 2005/04/13/received PY - 2006/01/05/revised PY - 2006/01/10/accepted PY - 2006/4/18/pubmed PY - 2006/10/13/medline PY - 2006/4/18/entrez SP - 444 EP - 53 JF - Biological psychiatry JO - Biol. Psychiatry VL - 60 IS - 5 N2 - BACKGROUND: The current study utilized magnetic resonance imaging (MRI) to more fully elucidate the relationship among age, regional white matter, and neuropsychological functioning. METHODS: One hundred ninety-nine neurologically healthy adults received MRI and standardized neuropsychological assessment. MR images were spatially normalized and segmented by tissue type; relative white matter values in each of the four cerebral lobes in each hemisphere were computed. Subjects were divided into Younger (ages 21-30), Middle (ages 31-54), and Older (ages 55-79) age groups. RESULTS: The Older group had significantly less overall relative white matter than the Middle group, who had significantly less overall relative white matter than the Younger participants (F (2, 193) = 5.42, p = 0.005). Differences in frontal lobe white matter were of largest magnitude, followed by temporal lobe (F (6, 579) = 3.32, p = 0.003). Age and frontal and temporal lobe white matter were primarily associated with performance on neuropsychological tests of executive functioning and memory. Mediational analysis suggested that frontal lobe white matter mediated the relationship between age and performance on tasks of executive functioning and memory. CONCLUSIONS: The results confirm age-associated decline in frontal and temporal white matter, and age-related cognitive decline in several domains. Decline in neuropsychological functioning is, in part, mediated by a relative age-related reduction in frontal white matter. SN - 0006-3223 UR - https://www.unboundmedicine.com/medline/citation/16616725/Regional_white_matter_and_neuropsychological_functioning_across_the_adult_lifespan_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-3223(06)00143-0 DB - PRIME DP - Unbound Medicine ER -