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Cases with mild cognitive impairment and Alzheimer's disease fail to benefit from repeated exposure to episodic memory tests as compared with controls.
J Clin Exp Neuropsychol. 2006 Apr; 28(3):438-55.JC

Abstract

Memory tests may be predictive for cognitive decline. We investigated the sensitivity and change in performance over time of the Hopkins Verbal Learning Test (HVLT) and the Mini-Mental Status Examination (MMSE) for Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD) when compared to cognitively healthy controls. Participants included elderly controls (n = 54), MCI (n = 19) and AD cases (n = 28) from OPTIMA. The MMSE and the HVLT (version 1) were administered twice to all subjects with an interval of 2-3 years.MCI and AD cases had poorer performance than controls on the HVLT and MMSE at both testing episodes (p < 0.05). The HVLT profile over time showed a learning effect in the control group (P < 0.0001), a trend to decline in the AD group (p = 0.09) and no change in the MCI group (P = 0.8). A subgroup of MCI subjects had lower HVLT scores at follow-up. The MMSE profile showed no significant change over time for all three groups (P > 0.05). The HVLT had better sensitivity and specificity compared to the MMSE for detecting MCI and AD. The HVLT is not only valuable for cross-sectional designs but has also proved to be valuable in a longitudinal design. Cognitively healthy controls showed evidence of learning strategies on the HVLT after a 2-3 year interval, with improved scores at the second testing episode. By contrast, an MCI group showed no benefits of previous exposure to this test. Lack of use of learning strategies on the HVLT may be an important marker of the likelihood of cognitive decline to MCI or dementia.

Authors+Show Affiliations

Department of Geriatrics, RIAGG, Roermond, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16618630

Citation

Schrijnemaekers, A M C., et al. "Cases With Mild Cognitive Impairment and Alzheimer's Disease Fail to Benefit From Repeated Exposure to Episodic Memory Tests as Compared With Controls." Journal of Clinical and Experimental Neuropsychology, vol. 28, no. 3, 2006, pp. 438-55.
Schrijnemaekers AM, de Jager CA, Hogervorst E, et al. Cases with mild cognitive impairment and Alzheimer's disease fail to benefit from repeated exposure to episodic memory tests as compared with controls. J Clin Exp Neuropsychol. 2006;28(3):438-55.
Schrijnemaekers, A. M., de Jager, C. A., Hogervorst, E., & Budge, M. M. (2006). Cases with mild cognitive impairment and Alzheimer's disease fail to benefit from repeated exposure to episodic memory tests as compared with controls. Journal of Clinical and Experimental Neuropsychology, 28(3), 438-55.
Schrijnemaekers AM, et al. Cases With Mild Cognitive Impairment and Alzheimer's Disease Fail to Benefit From Repeated Exposure to Episodic Memory Tests as Compared With Controls. J Clin Exp Neuropsychol. 2006;28(3):438-55. PubMed PMID: 16618630.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cases with mild cognitive impairment and Alzheimer's disease fail to benefit from repeated exposure to episodic memory tests as compared with controls. AU - Schrijnemaekers,A M C, AU - de Jager,Celeste A, AU - Hogervorst,E, AU - Budge,M M, PY - 2006/4/19/pubmed PY - 2006/6/3/medline PY - 2006/4/19/entrez SP - 438 EP - 55 JF - Journal of clinical and experimental neuropsychology JO - J Clin Exp Neuropsychol VL - 28 IS - 3 N2 - Memory tests may be predictive for cognitive decline. We investigated the sensitivity and change in performance over time of the Hopkins Verbal Learning Test (HVLT) and the Mini-Mental Status Examination (MMSE) for Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD) when compared to cognitively healthy controls. Participants included elderly controls (n = 54), MCI (n = 19) and AD cases (n = 28) from OPTIMA. The MMSE and the HVLT (version 1) were administered twice to all subjects with an interval of 2-3 years.MCI and AD cases had poorer performance than controls on the HVLT and MMSE at both testing episodes (p < 0.05). The HVLT profile over time showed a learning effect in the control group (P < 0.0001), a trend to decline in the AD group (p = 0.09) and no change in the MCI group (P = 0.8). A subgroup of MCI subjects had lower HVLT scores at follow-up. The MMSE profile showed no significant change over time for all three groups (P > 0.05). The HVLT had better sensitivity and specificity compared to the MMSE for detecting MCI and AD. The HVLT is not only valuable for cross-sectional designs but has also proved to be valuable in a longitudinal design. Cognitively healthy controls showed evidence of learning strategies on the HVLT after a 2-3 year interval, with improved scores at the second testing episode. By contrast, an MCI group showed no benefits of previous exposure to this test. Lack of use of learning strategies on the HVLT may be an important marker of the likelihood of cognitive decline to MCI or dementia. SN - 1380-3395 UR - https://www.unboundmedicine.com/medline/citation/16618630/Cases_with_mild_cognitive_impairment_and_Alzheimer's_disease_fail_to_benefit_from_repeated_exposure_to_episodic_memory_tests_as_compared_with_controls_ L2 - https://www.tandfonline.com/doi/full/10.1080/13803390590935462 DB - PRIME DP - Unbound Medicine ER -