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Response of cochlear blood flow to prostaglandin E1 applied topically to the round window.
Acta Otolaryngol. 2006 Mar; 126(3):232-6.AO

Abstract

CONCLUSIONS

The increase in cochlear blood flow (CBF) after administration of prostaglandin E1 (PGE1) to the round window depends on increased blood flow through the anterior inferior cerebellar artery (AICA).

OBJECTIVES

To evaluate the response of CBF to PGE1 applied topically to the round window, and to investigate the origin of blood flow changes after this topical application.

MATERIAL AND METHODS

The response of CBF to topically applied PGE1 was measured by placing the tip of a laser Doppler probe on the bony wall of the basal turn of the cochlea after the middle ear mucosa over the cochlea had been removed in guinea pigs and rats. In rats, the CBF response to PGE1 administration was investigated after occlusion of the AICA or stapedial artery.

RESULTS

CBF increased following PGE1 administration in both guinea pigs and rats. In rats, CBF increased from 100% to 132%+/-10% (mean+/-SD) after the topical application of 0.5 microl of a 0.014% PGE1 solution. CBF decreased after occlusion of the AICA or stapedial artery but did not increase after PGE1 administration during occlusion of the AICA. The CBF response to PGE1 administration was similar before and after occlusion of the stapedial artery.

Authors+Show Affiliations

Department of Otorhinolaryngology, Nagoya University School of Medicine, Nagoya, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16618646

Citation

Tominaga, Mitsuo, et al. "Response of Cochlear Blood Flow to Prostaglandin E1 Applied Topically to the Round Window." Acta Oto-laryngologica, vol. 126, no. 3, 2006, pp. 232-6.
Tominaga M, Yamamoto H, Sone M, et al. Response of cochlear blood flow to prostaglandin E1 applied topically to the round window. Acta Otolaryngol. 2006;126(3):232-6.
Tominaga, M., Yamamoto, H., Sone, M., Teranishi, M. A., & Nakashima, T. (2006). Response of cochlear blood flow to prostaglandin E1 applied topically to the round window. Acta Oto-laryngologica, 126(3), 232-6.
Tominaga M, et al. Response of Cochlear Blood Flow to Prostaglandin E1 Applied Topically to the Round Window. Acta Otolaryngol. 2006;126(3):232-6. PubMed PMID: 16618646.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Response of cochlear blood flow to prostaglandin E1 applied topically to the round window. AU - Tominaga,Mitsuo, AU - Yamamoto,Hiroshi, AU - Sone,Michihiko, AU - Teranishi,Masa-aki, AU - Nakashima,Tsutomu, PY - 2006/4/19/pubmed PY - 2006/8/5/medline PY - 2006/4/19/entrez SP - 232 EP - 6 JF - Acta oto-laryngologica JO - Acta Otolaryngol VL - 126 IS - 3 N2 - CONCLUSIONS: The increase in cochlear blood flow (CBF) after administration of prostaglandin E1 (PGE1) to the round window depends on increased blood flow through the anterior inferior cerebellar artery (AICA). OBJECTIVES: To evaluate the response of CBF to PGE1 applied topically to the round window, and to investigate the origin of blood flow changes after this topical application. MATERIAL AND METHODS: The response of CBF to topically applied PGE1 was measured by placing the tip of a laser Doppler probe on the bony wall of the basal turn of the cochlea after the middle ear mucosa over the cochlea had been removed in guinea pigs and rats. In rats, the CBF response to PGE1 administration was investigated after occlusion of the AICA or stapedial artery. RESULTS: CBF increased following PGE1 administration in both guinea pigs and rats. In rats, CBF increased from 100% to 132%+/-10% (mean+/-SD) after the topical application of 0.5 microl of a 0.014% PGE1 solution. CBF decreased after occlusion of the AICA or stapedial artery but did not increase after PGE1 administration during occlusion of the AICA. The CBF response to PGE1 administration was similar before and after occlusion of the stapedial artery. SN - 0001-6489 UR - https://www.unboundmedicine.com/medline/citation/16618646/Response_of_cochlear_blood_flow_to_prostaglandin_E1_applied_topically_to_the_round_window_ L2 - https://www.tandfonline.com/doi/full/10.1080/00016480500316803 DB - PRIME DP - Unbound Medicine ER -