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[Investigation of visceral hyperesthesia in irritable bowel syndrome].
Orv Hetil. 2006 Mar 05; 147(9):421-6.OH

Abstract

BACKGROUND

It has been well established that visceral hyperesthesia plays a role in the development of irritable bowel syndrome (IBS).

AIMS

1. to detect the possible changes of visceral perception in different subtypes of IBS patients, 2. to analyze the difference of visceral hyperaesthesia in different subtypes of IBS, 3. to examine whether distension protocols (e.g. phasic or ramp distension) has any influence on sensory thresholds, 4. to analyze the differences of perception thresholds produced by phasic or ramp distension in different subtypes of IBS.

METHODS

10 patients having colorectal polypectomy (control group) and 40 IBS patients were studied. The diagnosis was based on the Rome-II criteria. Diarrhoea-predominant, alternating and constipation-predominant subtypes were determined by the Talley bowel habit questionnaire. Sensory thresholds were detected by semi random ascending phasic and ramp rectosigmoid distension. Rectal dynamic compliance was calculated by using the dV/dP ratio.

RESULTS

1. The pain thresholds determined by phasic distension were significantly lower in all subtypes of IBS. 2. Increased thresholds for pain were found in almost half of constipation-predominant IBS patient determined by ramp distension. Thus two distinct subgroups could be found based on the findings of ramp distension: a normosensitive and a hyposensitive group. 3. Rectal dynamic compliance was significantly higher both in the constipation-predominant and alternating subtype of IBS patients.

CONCLUSION

Visceral hyperesthesia can be detected in all types of IBS. Tolerance to physiologic stimuli could be observed in constipating IBS patients that is not related to the increase of rectal compliance.

Authors+Show Affiliations

Pécs Tudományegyetem, Orvos- es Egészségtudományi Centrum, Altalános Orvostudományi Kar, III. Belgyógyászati Klinika. akiraly@clinic.pote.huNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

hun

PubMed ID

16619961

Citation

Király, Agnes, et al. "[Investigation of Visceral Hyperesthesia in Irritable Bowel Syndrome]." Orvosi Hetilap, vol. 147, no. 9, 2006, pp. 421-6.
Király A, Csizmadia C, Illés A, et al. [Investigation of visceral hyperesthesia in irritable bowel syndrome]. Orv Hetil. 2006;147(9):421-6.
Király, A., Csizmadia, C., Illés, A., & Undi, S. (2006). [Investigation of visceral hyperesthesia in irritable bowel syndrome]. Orvosi Hetilap, 147(9), 421-6.
Király A, et al. [Investigation of Visceral Hyperesthesia in Irritable Bowel Syndrome]. Orv Hetil. 2006 Mar 5;147(9):421-6. PubMed PMID: 16619961.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Investigation of visceral hyperesthesia in irritable bowel syndrome]. AU - Király,Agnes, AU - Csizmadia,Csaba, AU - Illés,Anita, AU - Undi,Sarolta, PY - 2006/4/20/pubmed PY - 2006/5/10/medline PY - 2006/4/20/entrez SP - 421 EP - 6 JF - Orvosi hetilap JO - Orv Hetil VL - 147 IS - 9 N2 - BACKGROUND: It has been well established that visceral hyperesthesia plays a role in the development of irritable bowel syndrome (IBS). AIMS: 1. to detect the possible changes of visceral perception in different subtypes of IBS patients, 2. to analyze the difference of visceral hyperaesthesia in different subtypes of IBS, 3. to examine whether distension protocols (e.g. phasic or ramp distension) has any influence on sensory thresholds, 4. to analyze the differences of perception thresholds produced by phasic or ramp distension in different subtypes of IBS. METHODS: 10 patients having colorectal polypectomy (control group) and 40 IBS patients were studied. The diagnosis was based on the Rome-II criteria. Diarrhoea-predominant, alternating and constipation-predominant subtypes were determined by the Talley bowel habit questionnaire. Sensory thresholds were detected by semi random ascending phasic and ramp rectosigmoid distension. Rectal dynamic compliance was calculated by using the dV/dP ratio. RESULTS: 1. The pain thresholds determined by phasic distension were significantly lower in all subtypes of IBS. 2. Increased thresholds for pain were found in almost half of constipation-predominant IBS patient determined by ramp distension. Thus two distinct subgroups could be found based on the findings of ramp distension: a normosensitive and a hyposensitive group. 3. Rectal dynamic compliance was significantly higher both in the constipation-predominant and alternating subtype of IBS patients. CONCLUSION: Visceral hyperesthesia can be detected in all types of IBS. Tolerance to physiologic stimuli could be observed in constipating IBS patients that is not related to the increase of rectal compliance. SN - 0030-6002 UR - https://www.unboundmedicine.com/medline/citation/16619961/[Investigation_of_visceral_hyperesthesia_in_irritable_bowel_syndrome]_ DB - PRIME DP - Unbound Medicine ER -