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Subcutaneous lispro and intravenous regular insulin treatments are equally effective and safe for the treatment of mild and moderate diabetic ketoacidosis in adult patients.
Int J Clin Pract. 2006 Apr; 60(4):429-33.IJ

Abstract

In this prospective, randomised, open trial, we wanted to evaluate the efficacy and safety of hourly subcutaneous (SC) insulin lispro administration in the treatment of diabetic ketoacidosis (DKA) in comparison with intravenous (IV) regular insulin treatment. Twenty patients were enrolled in the study. The patients were randomly assigned into two groups. Following a bolus injection of 0.15 U/kg IV regular insulin, group L received half of this dose as hourly SC insulin lispro while group R was treated conventionally with IV regular insulin infusion. At the end of treatment period, time that needed for normalisation of serum glucose, beta-hydroxybutyrate, blood pH and urine ketone levels were not different in groups L and R. There was no mortality or serious side effects in both groups. In this study, we revealed that treatment of mild and moderate DKA with SC insulin lispro is equally effective and safe in comparison with IV regular insulin.

Authors+Show Affiliations

Department of Endocrinology Metabolism,Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey. hersoz@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16620355

Citation

Ersöz, H O., et al. "Subcutaneous Lispro and Intravenous Regular Insulin Treatments Are Equally Effective and Safe for the Treatment of Mild and Moderate Diabetic Ketoacidosis in Adult Patients." International Journal of Clinical Practice, vol. 60, no. 4, 2006, pp. 429-33.
Ersöz HO, Ukinc K, Köse M, et al. Subcutaneous lispro and intravenous regular insulin treatments are equally effective and safe for the treatment of mild and moderate diabetic ketoacidosis in adult patients. Int J Clin Pract. 2006;60(4):429-33.
Ersöz, H. O., Ukinc, K., Köse, M., Erem, C., Gunduz, A., Hacihasanoglu, A. B., & Karti, S. S. (2006). Subcutaneous lispro and intravenous regular insulin treatments are equally effective and safe for the treatment of mild and moderate diabetic ketoacidosis in adult patients. International Journal of Clinical Practice, 60(4), 429-33.
Ersöz HO, et al. Subcutaneous Lispro and Intravenous Regular Insulin Treatments Are Equally Effective and Safe for the Treatment of Mild and Moderate Diabetic Ketoacidosis in Adult Patients. Int J Clin Pract. 2006;60(4):429-33. PubMed PMID: 16620355.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Subcutaneous lispro and intravenous regular insulin treatments are equally effective and safe for the treatment of mild and moderate diabetic ketoacidosis in adult patients. AU - Ersöz,H O, AU - Ukinc,K, AU - Köse,M, AU - Erem,C, AU - Gunduz,A, AU - Hacihasanoglu,A B, AU - Karti,S S, PY - 2006/4/20/pubmed PY - 2006/12/9/medline PY - 2006/4/20/entrez SP - 429 EP - 33 JF - International journal of clinical practice JO - Int. J. Clin. Pract. VL - 60 IS - 4 N2 - In this prospective, randomised, open trial, we wanted to evaluate the efficacy and safety of hourly subcutaneous (SC) insulin lispro administration in the treatment of diabetic ketoacidosis (DKA) in comparison with intravenous (IV) regular insulin treatment. Twenty patients were enrolled in the study. The patients were randomly assigned into two groups. Following a bolus injection of 0.15 U/kg IV regular insulin, group L received half of this dose as hourly SC insulin lispro while group R was treated conventionally with IV regular insulin infusion. At the end of treatment period, time that needed for normalisation of serum glucose, beta-hydroxybutyrate, blood pH and urine ketone levels were not different in groups L and R. There was no mortality or serious side effects in both groups. In this study, we revealed that treatment of mild and moderate DKA with SC insulin lispro is equally effective and safe in comparison with IV regular insulin. SN - 1368-5031 UR - https://www.unboundmedicine.com/medline/citation/16620355/Subcutaneous_lispro_and_intravenous_regular_insulin_treatments_are_equally_effective_and_safe_for_the_treatment_of_mild_and_moderate_diabetic_ketoacidosis_in_adult_patients_ L2 - https://doi.org/10.1111/j.1368-5031.2006.00786.x DB - PRIME DP - Unbound Medicine ER -