Tags

Type your tag names separated by a space and hit enter

Efficacy of stenting for unprotected left main coronary artery disease in 297 patients.
Chin Med J (Engl). 2006 Apr 05; 119(7):544-50.CM

Abstract

BACKGROUND

Angioplasty in the unprotected left main coronary artery (LMCA) has been controversial. This study aims to evaluate the safety and clinical effectiveness of stenting, including bare metal stent and drug eluting stent (DES), for treatment of unprotected LMCA disease.

METHODS

Between September 1997 and December 2005, a total of 297 consecutive patients underwent percutanous coronary intervention (PCI) on LMCA lesions in our hospital. Their in-hospital data and clinical follow-up outcomes were analyzed and those in pre-DES "era" (group I, from September 1997 to December 2002) were compared with those in DES "era" (group II, from January 2003 to December 2004. Patients in 2005 for the time of follow-up less than one year were not included in this group).

RESULTS

Altogether 368 coronary stents were successfully deployed in 295 patients. Stents failed to be implanted after balloon predilation in two patients, who received coronary artery bypass graft (CABG) successfully. Bifurcation techniques for distal LMCA executed in 206 patients (69.4%, 206/297), included crossover stenting in 156 (75.7%), T stenting in 4 (1.9%), provisional T stenting in 28 (13.6%), kissing stenting in 5 (2.4%) and stent crushing in 13 (6.3%) patients. During their hospital stay, 5 (1.7%) patients died after PCI procedure, of which 4 died from cardiac origin and one of renal failure. The total in-hospital major adverse cardiac events (MACE) were 2.0% (6/297). In the follow-up period, 19 patients (6.5%) died [15 (5.1%) of cardiac death and 4 of non-fatal myocardial infarction (MI)]. Besides, 2 (0.7%) developed subacute thrombosis (SAT) and 16 (5.4%) performed target lesion revascularization (TLR). The total follow-up MACE was 14.5% (43/297). Further analysis also showed that, compared with patients in group I, those in group II apparently had more multi-vessel involvement (14.7% vs 81.9%, P < 0.001), and more bifurcation lesions (32.4% vs 72.2%, P < 0.001). After PCI, in-hospital MACE of group II was significantly lower than that in group I (1.1% vs 9.4%, P < 0.05). And the incidences of MACE, TLR and angiographic restenosis in group II were all significantly lower than those in group I (all P < 0.05) after one year follow-up.

CONCLUSIONS

As new PCI strategies and intervention devices such as DES are developed, coronary stenting, which might have brought better in-hospital and long-term outcomes than CABG, are proved to be technically successful and can be safely applied for the treatment of LMCA lesions in the experienced center for coronary intervention.

Authors+Show Affiliations

Department of Cardiology, Shenyang General Hospital of PLA, Shenyang 110016, China. hanyal@mail.sy.ln.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16620694

Citation

Han, Ya-ling, et al. "Efficacy of Stenting for Unprotected Left Main Coronary Artery Disease in 297 Patients." Chinese Medical Journal, vol. 119, no. 7, 2006, pp. 544-50.
Han YL, Wang SL, Jin QM, et al. Efficacy of stenting for unprotected left main coronary artery disease in 297 patients. Chin Med J. 2006;119(7):544-50.
Han, Y. L., Wang, S. L., Jin, Q. M., Liu, H. W., Ma, Y. Y., Wang, Z. L., Wang, D. M., Luan, B., & Wang, G. (2006). Efficacy of stenting for unprotected left main coronary artery disease in 297 patients. Chinese Medical Journal, 119(7), 544-50.
Han YL, et al. Efficacy of Stenting for Unprotected Left Main Coronary Artery Disease in 297 Patients. Chin Med J. 2006 Apr 5;119(7):544-50. PubMed PMID: 16620694.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of stenting for unprotected left main coronary artery disease in 297 patients. AU - Han,Ya-ling, AU - Wang,Shou-li, AU - Jin,Quan-min, AU - Liu,Hai-wei, AU - Ma,Ying-yan, AU - Wang,Zhu-lu, AU - Wang,Dong-mei, AU - Luan,Bo, AU - Wang,Geng, PY - 2006/4/20/pubmed PY - 2006/5/26/medline PY - 2006/4/20/entrez SP - 544 EP - 50 JF - Chinese medical journal JO - Chin. Med. J. VL - 119 IS - 7 N2 - BACKGROUND: Angioplasty in the unprotected left main coronary artery (LMCA) has been controversial. This study aims to evaluate the safety and clinical effectiveness of stenting, including bare metal stent and drug eluting stent (DES), for treatment of unprotected LMCA disease. METHODS: Between September 1997 and December 2005, a total of 297 consecutive patients underwent percutanous coronary intervention (PCI) on LMCA lesions in our hospital. Their in-hospital data and clinical follow-up outcomes were analyzed and those in pre-DES "era" (group I, from September 1997 to December 2002) were compared with those in DES "era" (group II, from January 2003 to December 2004. Patients in 2005 for the time of follow-up less than one year were not included in this group). RESULTS: Altogether 368 coronary stents were successfully deployed in 295 patients. Stents failed to be implanted after balloon predilation in two patients, who received coronary artery bypass graft (CABG) successfully. Bifurcation techniques for distal LMCA executed in 206 patients (69.4%, 206/297), included crossover stenting in 156 (75.7%), T stenting in 4 (1.9%), provisional T stenting in 28 (13.6%), kissing stenting in 5 (2.4%) and stent crushing in 13 (6.3%) patients. During their hospital stay, 5 (1.7%) patients died after PCI procedure, of which 4 died from cardiac origin and one of renal failure. The total in-hospital major adverse cardiac events (MACE) were 2.0% (6/297). In the follow-up period, 19 patients (6.5%) died [15 (5.1%) of cardiac death and 4 of non-fatal myocardial infarction (MI)]. Besides, 2 (0.7%) developed subacute thrombosis (SAT) and 16 (5.4%) performed target lesion revascularization (TLR). The total follow-up MACE was 14.5% (43/297). Further analysis also showed that, compared with patients in group I, those in group II apparently had more multi-vessel involvement (14.7% vs 81.9%, P < 0.001), and more bifurcation lesions (32.4% vs 72.2%, P < 0.001). After PCI, in-hospital MACE of group II was significantly lower than that in group I (1.1% vs 9.4%, P < 0.05). And the incidences of MACE, TLR and angiographic restenosis in group II were all significantly lower than those in group I (all P < 0.05) after one year follow-up. CONCLUSIONS: As new PCI strategies and intervention devices such as DES are developed, coronary stenting, which might have brought better in-hospital and long-term outcomes than CABG, are proved to be technically successful and can be safely applied for the treatment of LMCA lesions in the experienced center for coronary intervention. SN - 0366-6999 UR - https://www.unboundmedicine.com/medline/citation/16620694/Efficacy_of_stenting_for_unprotected_left_main_coronary_artery_disease_in_297_patients_ L2 - http://Insights.ovid.com/pubmed?pmid=16620694 DB - PRIME DP - Unbound Medicine ER -