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Xanthine oxidase inhibitory activity of Lychnophora species from Brazil ("Arnica").
J Ethnopharmacol. 2006 Aug 11; 107(1):79-82.JE

Abstract

Twenty-two extracts from five Lychnophora species and one Lychnophoriopsis species, traditionally used in Brazil as analgesic, anti-inflammatory, and to treat bruise and rheumatism were examined for the inhibition of xanthine oxidase (XO), the enzyme that catalyses the metabolism of hypoxanthine and xanthine into uric acid. Sixteen extracts were tested. All of them were found to have excellent XO inhibitory activity, with inhibitions greater than 38% at 100 microg/mL in the assay mixture. The most active plants examined were Lychnophora trichocarpha, Lychnophora ericoides, Lychnophora staavioides and Lychnophoriopsis candelabrum, with inhibitions of 77%, 78%, 66% and 63% at 100 microg/mL, respectively, and IC(50) values of 6.16, 8.28, 33.97 and 37.70 microg/mL, respectively.

Authors+Show Affiliations

Laboratório de Farmacognosia e Fitoquímica, Escola de Farmácia, Universidade Federal de Ouro Preto, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16621372

Citation

Filha, Z S Ferraz, et al. "Xanthine Oxidase Inhibitory Activity of Lychnophora Species From Brazil ("Arnica")." Journal of Ethnopharmacology, vol. 107, no. 1, 2006, pp. 79-82.
Filha ZS, Vitolo IF, Fietto LG, et al. Xanthine oxidase inhibitory activity of Lychnophora species from Brazil ("Arnica"). J Ethnopharmacol. 2006;107(1):79-82.
Filha, Z. S., Vitolo, I. F., Fietto, L. G., Lombardi, J. A., & Saúde-Guimarães, D. A. (2006). Xanthine oxidase inhibitory activity of Lychnophora species from Brazil ("Arnica"). Journal of Ethnopharmacology, 107(1), 79-82.
Filha ZS, et al. Xanthine Oxidase Inhibitory Activity of Lychnophora Species From Brazil ("Arnica"). J Ethnopharmacol. 2006 Aug 11;107(1):79-82. PubMed PMID: 16621372.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Xanthine oxidase inhibitory activity of Lychnophora species from Brazil ("Arnica"). AU - Filha,Z S Ferraz, AU - Vitolo,I F, AU - Fietto,L G, AU - Lombardi,J A, AU - Saúde-Guimarães,D A, Y1 - 2006/02/28/ PY - 2005/02/10/received PY - 2006/01/12/revised PY - 2006/02/15/accepted PY - 2006/4/20/pubmed PY - 2006/12/9/medline PY - 2006/4/20/entrez SP - 79 EP - 82 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 107 IS - 1 N2 - Twenty-two extracts from five Lychnophora species and one Lychnophoriopsis species, traditionally used in Brazil as analgesic, anti-inflammatory, and to treat bruise and rheumatism were examined for the inhibition of xanthine oxidase (XO), the enzyme that catalyses the metabolism of hypoxanthine and xanthine into uric acid. Sixteen extracts were tested. All of them were found to have excellent XO inhibitory activity, with inhibitions greater than 38% at 100 microg/mL in the assay mixture. The most active plants examined were Lychnophora trichocarpha, Lychnophora ericoides, Lychnophora staavioides and Lychnophoriopsis candelabrum, with inhibitions of 77%, 78%, 66% and 63% at 100 microg/mL, respectively, and IC(50) values of 6.16, 8.28, 33.97 and 37.70 microg/mL, respectively. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/16621372/Xanthine_oxidase_inhibitory_activity_of_Lychnophora_species_from_Brazil__"Arnica"__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(06)00092-4 DB - PRIME DP - Unbound Medicine ER -