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Phylogenetic analysis of hepatitis E virus isolates in southern China (1994-1998).
J Clin Virol. 2006 Jun; 36(2):103-10.JC

Abstract

BACKGROUND

We have previously reported the identification of divergent hepatitis E virus (HEV) isolated (G9, G20 and 93G) in Guangzhou, a city in southern China. They are now recognised as a new HEV subgenotype in the world. However, the relatedness and significance of these novel isolates in sporadic HEV infection in southern China is still unclear.

OBJECTIVES

To perform phylogenetic analysis of nucleotide sequences from 41 HEV isolates in southern China from 1994 to 1998.

STUDY DESIGN

The partial nucleotide sequence of the HEV isolates were determined and compared with reported sequences in the GenBank. Their relatedness was analysed using computer software.

RESULTS

The majority of the HEV isolates, 39 out of 41, were found to belong to the Burmese-like isolates (genotype 1). The other two belonged to the Guangzhou-like isolates. The latter were only found in the samples collected in 1994. They, together with the G9 isolate, form a unique tree located between genotype 1 and genotype 4 (divergent HEV strains from northern China and Taiwan) on the phylogenetic tree.

CONCLUSION

Our results suggest that the Burmese-like isolates are the main causative agents of sporadic HEV infection in southern China. The Guangzhou-like isolates, which appeared transiently in 1994, did not seem to adapt to the environment and have caused no sporadic infection since.

Authors+Show Affiliations

The Municipal Infectious Disease Hospital of Guangzhou, 627 Dong Fong East Road, Guangzhou 510060, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16621689

Citation

Wei, Shaojing, et al. "Phylogenetic Analysis of Hepatitis E Virus Isolates in Southern China (1994-1998)." Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, vol. 36, no. 2, 2006, pp. 103-10.
Wei S, Xu Y, Wang M, et al. Phylogenetic analysis of hepatitis E virus isolates in southern China (1994-1998). J Clin Virol. 2006;36(2):103-10.
Wei, S., Xu, Y., Wang, M., & To, S. S. (2006). Phylogenetic analysis of hepatitis E virus isolates in southern China (1994-1998). Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, 36(2), 103-10.
Wei S, et al. Phylogenetic Analysis of Hepatitis E Virus Isolates in Southern China (1994-1998). J Clin Virol. 2006;36(2):103-10. PubMed PMID: 16621689.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phylogenetic analysis of hepatitis E virus isolates in southern China (1994-1998). AU - Wei,Shaojing, AU - Xu,Yangbin, AU - Wang,Meifang, AU - To,Shing Shun Tony, Y1 - 2006/04/19/ PY - 2005/03/21/received PY - 2006/03/02/revised PY - 2006/03/03/accepted PY - 2006/4/20/pubmed PY - 2006/8/4/medline PY - 2006/4/20/entrez SP - 103 EP - 10 JF - Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology JO - J Clin Virol VL - 36 IS - 2 N2 - BACKGROUND: We have previously reported the identification of divergent hepatitis E virus (HEV) isolated (G9, G20 and 93G) in Guangzhou, a city in southern China. They are now recognised as a new HEV subgenotype in the world. However, the relatedness and significance of these novel isolates in sporadic HEV infection in southern China is still unclear. OBJECTIVES: To perform phylogenetic analysis of nucleotide sequences from 41 HEV isolates in southern China from 1994 to 1998. STUDY DESIGN: The partial nucleotide sequence of the HEV isolates were determined and compared with reported sequences in the GenBank. Their relatedness was analysed using computer software. RESULTS: The majority of the HEV isolates, 39 out of 41, were found to belong to the Burmese-like isolates (genotype 1). The other two belonged to the Guangzhou-like isolates. The latter were only found in the samples collected in 1994. They, together with the G9 isolate, form a unique tree located between genotype 1 and genotype 4 (divergent HEV strains from northern China and Taiwan) on the phylogenetic tree. CONCLUSION: Our results suggest that the Burmese-like isolates are the main causative agents of sporadic HEV infection in southern China. The Guangzhou-like isolates, which appeared transiently in 1994, did not seem to adapt to the environment and have caused no sporadic infection since. SN - 1386-6532 UR - https://www.unboundmedicine.com/medline/citation/16621689/Phylogenetic_analysis_of_hepatitis_E_virus_isolates_in_southern_China__1994_1998__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1386-6532(06)00080-1 DB - PRIME DP - Unbound Medicine ER -