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Agricultural pesticide use and risk of t(14;18)-defined subtypes of non-Hodgkin lymphoma.
Blood. 2006 Aug 15; 108(4):1363-9.Blood

Abstract

Pesticides have been specifically associated with the t(14;18)(q32;q21) chromosomal translocation. To investigate whether the association between pesticides and risk of non-Hodgkin lymphoma (NHL) differs for molecular subtypes of NHL defined by t(14; 18) status, we obtained 175 tumor blocks from case subjects in a population-based case-control study conducted in Nebraska between 1983 and 1986. The t(14;18) was determined by interphase fluorescence in situ hybridization in 172 of 175 tumor blocks. We compared exposures to insecticides, herbicides, fungicides, and fumigants in 65 t(14;18)-positive and 107 t(14;18)-negative case subjects with those among 1432 control subjects. Multivariate polytomous logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Compared with farmers who never used pesticides, the risk of t(14;18)-positive NHL was significantly elevated among farmers who used animal insecticides (OR = 2.6; 95% CI, 1.0-6.9), crop insecticides (OR = 3.0; 95% CI, 1.1-8.2), herbicides (OR = 2.9; 95% CI, 1.1-7.9), and fumigants (OR = 5.0; 95% CI, 1.7-14.5). None of these pesticides were associated with t(14;18)-negative NHL. The risk of t(14;18)-positive NHL associated with insecticides and herbicides increased with longer duration of use. We conclude that insecticides, herbicides, and fumigants were associated with risk of t(14;18)-positive NHL but not t(14;18)-negative NHL. These results suggest that defining subsets of NHL according to t(14;18) status is a useful approach for etiologic research.

Authors+Show Affiliations

Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611-4402, USA. bchiu@northwestern.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

16621961

Citation

Chiu, Brian C-H, et al. "Agricultural Pesticide Use and Risk of T(14;18)-defined Subtypes of non-Hodgkin Lymphoma." Blood, vol. 108, no. 4, 2006, pp. 1363-9.
Chiu BC, Dave BJ, Blair A, et al. Agricultural pesticide use and risk of t(14;18)-defined subtypes of non-Hodgkin lymphoma. Blood. 2006;108(4):1363-9.
Chiu, B. C., Dave, B. J., Blair, A., Gapstur, S. M., Zahm, S. H., & Weisenburger, D. D. (2006). Agricultural pesticide use and risk of t(14;18)-defined subtypes of non-Hodgkin lymphoma. Blood, 108(4), 1363-9.
Chiu BC, et al. Agricultural Pesticide Use and Risk of T(14;18)-defined Subtypes of non-Hodgkin Lymphoma. Blood. 2006 Aug 15;108(4):1363-9. PubMed PMID: 16621961.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Agricultural pesticide use and risk of t(14;18)-defined subtypes of non-Hodgkin lymphoma. AU - Chiu,Brian C-H, AU - Dave,Bhavana J, AU - Blair,Aaron, AU - Gapstur,Susan M, AU - Zahm,Shelia Hoar, AU - Weisenburger,Dennis D, Y1 - 2006/04/18/ PY - 2006/4/20/pubmed PY - 2006/9/13/medline PY - 2006/4/20/entrez SP - 1363 EP - 9 JF - Blood JO - Blood VL - 108 IS - 4 N2 - Pesticides have been specifically associated with the t(14;18)(q32;q21) chromosomal translocation. To investigate whether the association between pesticides and risk of non-Hodgkin lymphoma (NHL) differs for molecular subtypes of NHL defined by t(14; 18) status, we obtained 175 tumor blocks from case subjects in a population-based case-control study conducted in Nebraska between 1983 and 1986. The t(14;18) was determined by interphase fluorescence in situ hybridization in 172 of 175 tumor blocks. We compared exposures to insecticides, herbicides, fungicides, and fumigants in 65 t(14;18)-positive and 107 t(14;18)-negative case subjects with those among 1432 control subjects. Multivariate polytomous logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Compared with farmers who never used pesticides, the risk of t(14;18)-positive NHL was significantly elevated among farmers who used animal insecticides (OR = 2.6; 95% CI, 1.0-6.9), crop insecticides (OR = 3.0; 95% CI, 1.1-8.2), herbicides (OR = 2.9; 95% CI, 1.1-7.9), and fumigants (OR = 5.0; 95% CI, 1.7-14.5). None of these pesticides were associated with t(14;18)-negative NHL. The risk of t(14;18)-positive NHL associated with insecticides and herbicides increased with longer duration of use. We conclude that insecticides, herbicides, and fumigants were associated with risk of t(14;18)-positive NHL but not t(14;18)-negative NHL. These results suggest that defining subsets of NHL according to t(14;18) status is a useful approach for etiologic research. SN - 0006-4971 UR - https://www.unboundmedicine.com/medline/citation/16621961/Agricultural_pesticide_use_and_risk_of_t_14 L2 - https://ashpublications.org/blood/article-lookup/doi/10.1182/blood-2005-12-008755 DB - PRIME DP - Unbound Medicine ER -