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Relationship between gastric emptying and gastroesophageal reflux in infants and children.
Clin Nucl Med. 2006 May; 31(5):262-5.CN

Abstract

PURPOSE

The aim of our study was to evaluate the relationship between gastric emptying and gastroesophageal reflux (GER) in infants and children.

METHODS AND MATERIALS

One hundred eight patients (pts) between 3 months and 5 years of age (77 boys, 31 girls) with clinical suspicion of GER disease were included in the study. Patients were divided into 2 groups according to the age range: group A, 0-2 years (57 pts), and group B, 2-5 (51 pts) years. Each group was divided into 2 subgroups according to the scintigraphic study as GER-positive and -negative. Cow's milk with Tc-99m sulfur colloid as radiotracer was used. Gastric emptying was expressed as the half emptying time (T1/2). The detection of activity in the esophagus at any time during scintigraphy was considered an indicator of GER episodes. Reflux episodes were graded as grade 1 if activity was detected on one or 2 frames and grade 2 if activity was detected on more than 2 frames.

RESULTS

Forty of the 108 patients (37%) had GER findings on scintigraphy. The comparison of gastric emptying time between positive GER scintigraphy and negative GER scintigraphy groups was not statistically significant in any age group. No association was found between age and rate of gastric emptying time. Although the comparison of T1/2 between grade 1 patients and the GER-negative group was not statistically significant, grade 2 patients showed significant differences and had prolonged gastric emptying times. Mild statistical correlation between the number of reflux episodes and gastric emptying half time was found.

CONCLUSIONS

As a conclusion, the relation between gastroesophageal reflux and delayed gastric emptying cannot be ignored. Our results support delayed gastric emptying to be a pathogenetic factor in gastroesophageal reflux in infants and children.

Authors+Show Affiliations

Department of Nuclear Medicine, Ege University Medical Faculty, Izmir, Bornova, Turkey. argon@egenet.com.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

16622332

Citation

Argon, Murat, et al. "Relationship Between Gastric Emptying and Gastroesophageal Reflux in Infants and Children." Clinical Nuclear Medicine, vol. 31, no. 5, 2006, pp. 262-5.
Argon M, Duygun U, Daglioz G, et al. Relationship between gastric emptying and gastroesophageal reflux in infants and children. Clin Nucl Med. 2006;31(5):262-5.
Argon, M., Duygun, U., Daglioz, G., Omür, O., Demir, E., & Aydogdu, S. (2006). Relationship between gastric emptying and gastroesophageal reflux in infants and children. Clinical Nuclear Medicine, 31(5), 262-5.
Argon M, et al. Relationship Between Gastric Emptying and Gastroesophageal Reflux in Infants and Children. Clin Nucl Med. 2006;31(5):262-5. PubMed PMID: 16622332.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between gastric emptying and gastroesophageal reflux in infants and children. AU - Argon,Murat, AU - Duygun,Ulkem, AU - Daglioz,Gozde, AU - Omür,Ozgur, AU - Demir,Esen, AU - Aydogdu,Sema, PY - 2006/4/20/pubmed PY - 2006/9/6/medline PY - 2006/4/20/entrez SP - 262 EP - 5 JF - Clinical nuclear medicine JO - Clin Nucl Med VL - 31 IS - 5 N2 - PURPOSE: The aim of our study was to evaluate the relationship between gastric emptying and gastroesophageal reflux (GER) in infants and children. METHODS AND MATERIALS: One hundred eight patients (pts) between 3 months and 5 years of age (77 boys, 31 girls) with clinical suspicion of GER disease were included in the study. Patients were divided into 2 groups according to the age range: group A, 0-2 years (57 pts), and group B, 2-5 (51 pts) years. Each group was divided into 2 subgroups according to the scintigraphic study as GER-positive and -negative. Cow's milk with Tc-99m sulfur colloid as radiotracer was used. Gastric emptying was expressed as the half emptying time (T1/2). The detection of activity in the esophagus at any time during scintigraphy was considered an indicator of GER episodes. Reflux episodes were graded as grade 1 if activity was detected on one or 2 frames and grade 2 if activity was detected on more than 2 frames. RESULTS: Forty of the 108 patients (37%) had GER findings on scintigraphy. The comparison of gastric emptying time between positive GER scintigraphy and negative GER scintigraphy groups was not statistically significant in any age group. No association was found between age and rate of gastric emptying time. Although the comparison of T1/2 between grade 1 patients and the GER-negative group was not statistically significant, grade 2 patients showed significant differences and had prolonged gastric emptying times. Mild statistical correlation between the number of reflux episodes and gastric emptying half time was found. CONCLUSIONS: As a conclusion, the relation between gastroesophageal reflux and delayed gastric emptying cannot be ignored. Our results support delayed gastric emptying to be a pathogenetic factor in gastroesophageal reflux in infants and children. SN - 0363-9762 UR - https://www.unboundmedicine.com/medline/citation/16622332/Relationship_between_gastric_emptying_and_gastroesophageal_reflux_in_infants_and_children_ L2 - https://dx.doi.org/10.1097/01.rlu.0000210500.64440.76 DB - PRIME DP - Unbound Medicine ER -