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Mediterranean diet and risk for Alzheimer's disease.
Ann Neurol 2006; 59(6):912-21AN

Abstract

OBJECTIVE

Previous research in Alzheimer's disease (AD) has focused on individual dietary components. There is converging evidence that composite dietary patterns such as the Mediterranean diet (MeDi) is related to lower risk for cardiovascular disease, several forms of cancer, and overall mortality. We sought to investigate the association between MeDi and risk for AD.

METHODS

A total of 2,258 community-based nondemented individuals in New York were prospectively evaluated every 1.5 years. Adherence to the MeDi (zero- to nine-point scale with higher scores indicating higher adherence) was the main predictor in models that were adjusted for cohort, age, sex, ethnicity, education, apolipoprotein E genotype, caloric intake, smoking, medical comorbidity index, and body mass index.

RESULTS

There were 262 incident AD cases during the course of 4 (+/-3.0; range, 0.2-13.9) years of follow-up. Higher adherence to the MeDi was associated with lower risk for AD (hazard ratio, 0.91; 95% confidence interval, 0.83-0.98; p=0.015). Compared with subjects in the lowest MeDi tertile, subjects in the middle MeDi tertile had a hazard ratio of 0.85 (95% confidence interval, 0.63-1.16) and those at the highest tertile had a hazard ratio of 0.60 (95% confidence interval, 0.42-0.87) for AD (p for trend=0.007).

INTERPRETATION

We conclude that higher adherence to the MeDi is associated with a reduction in risk for AD.

Authors+Show Affiliations

Taub Institute for Research in Alzheimer's Disease and the Aging Brain, New York, NY 10032, USA. ns257@columbia.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16622828

Citation

Scarmeas, Nikolaos, et al. "Mediterranean Diet and Risk for Alzheimer's Disease." Annals of Neurology, vol. 59, no. 6, 2006, pp. 912-21.
Scarmeas N, Stern Y, Tang MX, et al. Mediterranean diet and risk for Alzheimer's disease. Ann Neurol. 2006;59(6):912-21.
Scarmeas, N., Stern, Y., Tang, M. X., Mayeux, R., & Luchsinger, J. A. (2006). Mediterranean diet and risk for Alzheimer's disease. Annals of Neurology, 59(6), pp. 912-21.
Scarmeas N, et al. Mediterranean Diet and Risk for Alzheimer's Disease. Ann Neurol. 2006;59(6):912-21. PubMed PMID: 16622828.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mediterranean diet and risk for Alzheimer's disease. AU - Scarmeas,Nikolaos, AU - Stern,Yaakov, AU - Tang,Ming-Xin, AU - Mayeux,Richard, AU - Luchsinger,Jose A, PY - 2006/4/20/pubmed PY - 2006/7/15/medline PY - 2006/4/20/entrez SP - 912 EP - 21 JF - Annals of neurology JO - Ann. Neurol. VL - 59 IS - 6 N2 - OBJECTIVE: Previous research in Alzheimer's disease (AD) has focused on individual dietary components. There is converging evidence that composite dietary patterns such as the Mediterranean diet (MeDi) is related to lower risk for cardiovascular disease, several forms of cancer, and overall mortality. We sought to investigate the association between MeDi and risk for AD. METHODS: A total of 2,258 community-based nondemented individuals in New York were prospectively evaluated every 1.5 years. Adherence to the MeDi (zero- to nine-point scale with higher scores indicating higher adherence) was the main predictor in models that were adjusted for cohort, age, sex, ethnicity, education, apolipoprotein E genotype, caloric intake, smoking, medical comorbidity index, and body mass index. RESULTS: There were 262 incident AD cases during the course of 4 (+/-3.0; range, 0.2-13.9) years of follow-up. Higher adherence to the MeDi was associated with lower risk for AD (hazard ratio, 0.91; 95% confidence interval, 0.83-0.98; p=0.015). Compared with subjects in the lowest MeDi tertile, subjects in the middle MeDi tertile had a hazard ratio of 0.85 (95% confidence interval, 0.63-1.16) and those at the highest tertile had a hazard ratio of 0.60 (95% confidence interval, 0.42-0.87) for AD (p for trend=0.007). INTERPRETATION: We conclude that higher adherence to the MeDi is associated with a reduction in risk for AD. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/16622828/Mediterranean_diet_and_risk_for_Alzheimer's_disease_ L2 - https://doi.org/10.1002/ana.20854 DB - PRIME DP - Unbound Medicine ER -