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Mediterranean diet and risk for Alzheimer's disease.

Abstract

OBJECTIVE

Previous research in Alzheimer's disease (AD) has focused on individual dietary components. There is converging evidence that composite dietary patterns such as the Mediterranean diet (MeDi) is related to lower risk for cardiovascular disease, several forms of cancer, and overall mortality. We sought to investigate the association between MeDi and risk for AD.

METHODS

A total of 2,258 community-based nondemented individuals in New York were prospectively evaluated every 1.5 years. Adherence to the MeDi (zero- to nine-point scale with higher scores indicating higher adherence) was the main predictor in models that were adjusted for cohort, age, sex, ethnicity, education, apolipoprotein E genotype, caloric intake, smoking, medical comorbidity index, and body mass index.

RESULTS

There were 262 incident AD cases during the course of 4 (+/-3.0; range, 0.2-13.9) years of follow-up. Higher adherence to the MeDi was associated with lower risk for AD (hazard ratio, 0.91; 95% confidence interval, 0.83-0.98; p=0.015). Compared with subjects in the lowest MeDi tertile, subjects in the middle MeDi tertile had a hazard ratio of 0.85 (95% confidence interval, 0.63-1.16) and those at the highest tertile had a hazard ratio of 0.60 (95% confidence interval, 0.42-0.87) for AD (p for trend=0.007).

INTERPRETATION

We conclude that higher adherence to the MeDi is associated with a reduction in risk for AD.

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  • Authors+Show Affiliations

    ,

    Taub Institute for Research in Alzheimer's Disease and the Aging Brain, New York, NY 10032, USA. ns257@columbia.edu

    , , ,

    Source

    Annals of neurology 59:6 2006 Jun pg 912-21

    MeSH

    Aged
    Alzheimer Disease
    Diet, Mediterranean
    Female
    Humans
    Male
    Neuropsychological Tests
    New York City
    Risk Factors
    Socioeconomic Factors

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16622828

    Citation

    Scarmeas, Nikolaos, et al. "Mediterranean Diet and Risk for Alzheimer's Disease." Annals of Neurology, vol. 59, no. 6, 2006, pp. 912-21.
    Scarmeas N, Stern Y, Tang MX, et al. Mediterranean diet and risk for Alzheimer's disease. Ann Neurol. 2006;59(6):912-21.
    Scarmeas, N., Stern, Y., Tang, M. X., Mayeux, R., & Luchsinger, J. A. (2006). Mediterranean diet and risk for Alzheimer's disease. Annals of Neurology, 59(6), pp. 912-21.
    Scarmeas N, et al. Mediterranean Diet and Risk for Alzheimer's Disease. Ann Neurol. 2006;59(6):912-21. PubMed PMID: 16622828.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Mediterranean diet and risk for Alzheimer's disease. AU - Scarmeas,Nikolaos, AU - Stern,Yaakov, AU - Tang,Ming-Xin, AU - Mayeux,Richard, AU - Luchsinger,Jose A, PY - 2006/4/20/pubmed PY - 2006/7/15/medline PY - 2006/4/20/entrez SP - 912 EP - 21 JF - Annals of neurology JO - Ann. Neurol. VL - 59 IS - 6 N2 - OBJECTIVE: Previous research in Alzheimer's disease (AD) has focused on individual dietary components. There is converging evidence that composite dietary patterns such as the Mediterranean diet (MeDi) is related to lower risk for cardiovascular disease, several forms of cancer, and overall mortality. We sought to investigate the association between MeDi and risk for AD. METHODS: A total of 2,258 community-based nondemented individuals in New York were prospectively evaluated every 1.5 years. Adherence to the MeDi (zero- to nine-point scale with higher scores indicating higher adherence) was the main predictor in models that were adjusted for cohort, age, sex, ethnicity, education, apolipoprotein E genotype, caloric intake, smoking, medical comorbidity index, and body mass index. RESULTS: There were 262 incident AD cases during the course of 4 (+/-3.0; range, 0.2-13.9) years of follow-up. Higher adherence to the MeDi was associated with lower risk for AD (hazard ratio, 0.91; 95% confidence interval, 0.83-0.98; p=0.015). Compared with subjects in the lowest MeDi tertile, subjects in the middle MeDi tertile had a hazard ratio of 0.85 (95% confidence interval, 0.63-1.16) and those at the highest tertile had a hazard ratio of 0.60 (95% confidence interval, 0.42-0.87) for AD (p for trend=0.007). INTERPRETATION: We conclude that higher adherence to the MeDi is associated with a reduction in risk for AD. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/16622828/Mediterranean_diet_and_risk_for_Alzheimer's_disease_ L2 - https://doi.org/10.1002/ana.20854 DB - PRIME DP - Unbound Medicine ER -