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Fluorodeoxyglucose positron emission tomography with sentinel lymph node biopsy for evaluation of axillary involvement in breast cancer.
Br J Surg. 2006 Jun; 93(6):707-12.BJ

Abstract

BACKGROUND

This study analysed the value of [(18)F]fluorodeoxyglucose positron emission tomography (FDG-PET) in detecting axillary lymph node involvement in women with breast cancer.

METHODS

In the first 150 women in this prospective study, axillary lymph node dissection (ALND) was performed regardless of the PET results. In a second group (125 women) FDG-PET was complemented with sentinel lymph node biopsy (SLNB) only in those who did not have pathological axillary uptake.

RESULTS

The sensitivity and specificity of FDG-PET in detecting axillary involvement was 84.5 and 98.5 per cent respectively in the whole series of 275 patients, with two false-positive and 22 false-negative results. False-negative results were associated with some intrinsic tumour characteristics. In 21 women, PET revealed pathological uptake, suggesting involvement of the internal mammary lymph node chain. Whole-body PET identified a second synchronous tumour in five asymptomatic patients and haematogenous metastases in two patients.

CONCLUSION

The high positive predictive value of PET (98.4 per cent) suggests that FDG uptake in the axilla could be an indication for full ALND without previous SLNB.

Authors+Show Affiliations

Department of General Surgery, Clinica Universitaria of Navarra, C/Pío XII 36, 31008 Pamplona, Navarre, Spain. agilrendo@telefonica.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16622900

Citation

Gil-Rendo, A, et al. "Fluorodeoxyglucose Positron Emission Tomography With Sentinel Lymph Node Biopsy for Evaluation of Axillary Involvement in Breast Cancer." The British Journal of Surgery, vol. 93, no. 6, 2006, pp. 707-12.
Gil-Rendo A, Zornoza G, García-Velloso MJ, et al. Fluorodeoxyglucose positron emission tomography with sentinel lymph node biopsy for evaluation of axillary involvement in breast cancer. Br J Surg. 2006;93(6):707-12.
Gil-Rendo, A., Zornoza, G., García-Velloso, M. J., Regueira, F. M., Beorlegui, C., & Cervera, M. (2006). Fluorodeoxyglucose positron emission tomography with sentinel lymph node biopsy for evaluation of axillary involvement in breast cancer. The British Journal of Surgery, 93(6), 707-12.
Gil-Rendo A, et al. Fluorodeoxyglucose Positron Emission Tomography With Sentinel Lymph Node Biopsy for Evaluation of Axillary Involvement in Breast Cancer. Br J Surg. 2006;93(6):707-12. PubMed PMID: 16622900.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fluorodeoxyglucose positron emission tomography with sentinel lymph node biopsy for evaluation of axillary involvement in breast cancer. AU - Gil-Rendo,A, AU - Zornoza,G, AU - García-Velloso,M J, AU - Regueira,F M, AU - Beorlegui,C, AU - Cervera,M, PY - 2006/4/20/pubmed PY - 2006/7/13/medline PY - 2006/4/20/entrez SP - 707 EP - 12 JF - The British journal of surgery JO - Br J Surg VL - 93 IS - 6 N2 - BACKGROUND: This study analysed the value of [(18)F]fluorodeoxyglucose positron emission tomography (FDG-PET) in detecting axillary lymph node involvement in women with breast cancer. METHODS: In the first 150 women in this prospective study, axillary lymph node dissection (ALND) was performed regardless of the PET results. In a second group (125 women) FDG-PET was complemented with sentinel lymph node biopsy (SLNB) only in those who did not have pathological axillary uptake. RESULTS: The sensitivity and specificity of FDG-PET in detecting axillary involvement was 84.5 and 98.5 per cent respectively in the whole series of 275 patients, with two false-positive and 22 false-negative results. False-negative results were associated with some intrinsic tumour characteristics. In 21 women, PET revealed pathological uptake, suggesting involvement of the internal mammary lymph node chain. Whole-body PET identified a second synchronous tumour in five asymptomatic patients and haematogenous metastases in two patients. CONCLUSION: The high positive predictive value of PET (98.4 per cent) suggests that FDG uptake in the axilla could be an indication for full ALND without previous SLNB. SN - 0007-1323 UR - https://www.unboundmedicine.com/medline/citation/16622900/Fluorodeoxyglucose_positron_emission_tomography_with_sentinel_lymph_node_biopsy_for_evaluation_of_axillary_involvement_in_breast_cancer_ L2 - https://academic.oup.com/bjs/article-lookup/doi/10.1002/bjs.5338 DB - PRIME DP - Unbound Medicine ER -