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Association of plasminogen activators and matrix metalloproteinase-9 proteolytic cascade with blood-CNS barrier damage of angiostrongyliasis.
Int J Exp Pathol. 2006 Apr; 87(2):113-9.IJ

Abstract

Blood-central nervous system (blood-CNS) barrier breakdown, an important pathophysiological event in meningitis, results in extravasation of leucocytes into subarachnoid space. The blood-CNS barrier disruption is mediated by primarily two enzyme systems, the plasminogen activators (PAs) and matrix metalloproteinases (MMPs). The present study showed that the activities of tissue-type PA (tPA), urokinase-type activator (uPA) and MMP-9 in cerebrospinal-like fluid (CSF-like fluid) were significantly increased in mice with eosinophilic meningitis compared with uninfected mice. Eosinophilia significantly correlated with tPA, uPA and MMP-9 activities, and albumin concentration. In addition, when GM6001, a specific matrix metalloproteinase blocker, was injected into infected mice, MMP-9 activity and total protein concentrations declined from their preinjection highs. These results suggest that the PAs and MMP-9 proteolytic cascade may be associated with blood-CNS barrier disruption in eosinophilic meningitis caused by Angiostrongylus cantonensis.

Authors+Show Affiliations

Department of Parasitology, Chung Shan Medical University, Taichung 402, Taiwan. kmc@csmu.edu.twNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16623755

Citation

Chen, Ke-Min, et al. "Association of Plasminogen Activators and Matrix Metalloproteinase-9 Proteolytic Cascade With blood-CNS Barrier Damage of Angiostrongyliasis." International Journal of Experimental Pathology, vol. 87, no. 2, 2006, pp. 113-9.
Chen KM, Liu JY, Lai SC, et al. Association of plasminogen activators and matrix metalloproteinase-9 proteolytic cascade with blood-CNS barrier damage of angiostrongyliasis. Int J Exp Pathol. 2006;87(2):113-9.
Chen, K. M., Liu, J. Y., Lai, S. C., Hsu, L. S., & Lee, H. H. (2006). Association of plasminogen activators and matrix metalloproteinase-9 proteolytic cascade with blood-CNS barrier damage of angiostrongyliasis. International Journal of Experimental Pathology, 87(2), 113-9.
Chen KM, et al. Association of Plasminogen Activators and Matrix Metalloproteinase-9 Proteolytic Cascade With blood-CNS Barrier Damage of Angiostrongyliasis. Int J Exp Pathol. 2006;87(2):113-9. PubMed PMID: 16623755.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of plasminogen activators and matrix metalloproteinase-9 proteolytic cascade with blood-CNS barrier damage of angiostrongyliasis. AU - Chen,Ke-Min, AU - Liu,Jer-Yuh, AU - Lai,Shih-Chan, AU - Hsu,Li-Sung, AU - Lee,Hsiu-Hsiung, PY - 2006/4/21/pubmed PY - 2006/6/29/medline PY - 2006/4/21/entrez SP - 113 EP - 9 JF - International journal of experimental pathology JO - Int J Exp Pathol VL - 87 IS - 2 N2 - Blood-central nervous system (blood-CNS) barrier breakdown, an important pathophysiological event in meningitis, results in extravasation of leucocytes into subarachnoid space. The blood-CNS barrier disruption is mediated by primarily two enzyme systems, the plasminogen activators (PAs) and matrix metalloproteinases (MMPs). The present study showed that the activities of tissue-type PA (tPA), urokinase-type activator (uPA) and MMP-9 in cerebrospinal-like fluid (CSF-like fluid) were significantly increased in mice with eosinophilic meningitis compared with uninfected mice. Eosinophilia significantly correlated with tPA, uPA and MMP-9 activities, and albumin concentration. In addition, when GM6001, a specific matrix metalloproteinase blocker, was injected into infected mice, MMP-9 activity and total protein concentrations declined from their preinjection highs. These results suggest that the PAs and MMP-9 proteolytic cascade may be associated with blood-CNS barrier disruption in eosinophilic meningitis caused by Angiostrongylus cantonensis. SN - 0959-9673 UR - https://www.unboundmedicine.com/medline/citation/16623755/Association_of_plasminogen_activators_and_matrix_metalloproteinase_9_proteolytic_cascade_with_blood_CNS_barrier_damage_of_angiostrongyliasis_ L2 - https://doi.org/10.1111/j.0959-9673.2006.00459.x DB - PRIME DP - Unbound Medicine ER -