Tags

Type your tag names separated by a space and hit enter

Variations in the human cannabinoid receptor (CNR1) gene modulate striatal responses to happy faces.
Eur J Neurosci. 2006 Apr; 23(7):1944-8.EJ

Abstract

Happy facial expressions are innate social rewards and evoke a response in the striatum, a region known for its role in reward processing in rats, primates and humans. The cannabinoid receptor 1 (CNR1) is the best-characterized molecule of the endocannabinoid system, involved in processing rewards. We hypothesized that genetic variation in human CNR1 gene would predict differences in the striatal response to happy faces. In a 3T functional magnetic resonance imaging (fMRI) scanning study on 19 Caucasian volunteers, we report that four single nucleotide polymorphisms (SNPs) in the CNR1 locus modulate differential striatal response to happy but not to disgust faces. This suggests a role for the variations of the CNR1 gene in underlying social reward responsivity. Future studies should aim to replicate this finding with a balanced design in a larger sample, but these preliminary results suggest neural responsivity to emotional and socially rewarding stimuli varies as a function of CNR1 genotype. This has implications for medical conditions involving hypo-responsivity to emotional and social stimuli, such as autism.

Authors+Show Affiliations

Autism Research Centre, Douglas House, 18 B, Trumpington Road, Cambridge CB2 2AH, UK. bc249@cam.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16623851

Citation

Chakrabarti, Bhismadev, et al. "Variations in the Human Cannabinoid Receptor (CNR1) Gene Modulate Striatal Responses to Happy Faces." The European Journal of Neuroscience, vol. 23, no. 7, 2006, pp. 1944-8.
Chakrabarti B, Kent L, Suckling J, et al. Variations in the human cannabinoid receptor (CNR1) gene modulate striatal responses to happy faces. Eur J Neurosci. 2006;23(7):1944-8.
Chakrabarti, B., Kent, L., Suckling, J., Bullmore, E., & Baron-Cohen, S. (2006). Variations in the human cannabinoid receptor (CNR1) gene modulate striatal responses to happy faces. The European Journal of Neuroscience, 23(7), 1944-8.
Chakrabarti B, et al. Variations in the Human Cannabinoid Receptor (CNR1) Gene Modulate Striatal Responses to Happy Faces. Eur J Neurosci. 2006;23(7):1944-8. PubMed PMID: 16623851.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Variations in the human cannabinoid receptor (CNR1) gene modulate striatal responses to happy faces. AU - Chakrabarti,Bhismadev, AU - Kent,Lindsey, AU - Suckling,John, AU - Bullmore,Edward, AU - Baron-Cohen,Simon, PY - 2006/4/21/pubmed PY - 2006/5/31/medline PY - 2006/4/21/entrez SP - 1944 EP - 8 JF - The European journal of neuroscience JO - Eur. J. Neurosci. VL - 23 IS - 7 N2 - Happy facial expressions are innate social rewards and evoke a response in the striatum, a region known for its role in reward processing in rats, primates and humans. The cannabinoid receptor 1 (CNR1) is the best-characterized molecule of the endocannabinoid system, involved in processing rewards. We hypothesized that genetic variation in human CNR1 gene would predict differences in the striatal response to happy faces. In a 3T functional magnetic resonance imaging (fMRI) scanning study on 19 Caucasian volunteers, we report that four single nucleotide polymorphisms (SNPs) in the CNR1 locus modulate differential striatal response to happy but not to disgust faces. This suggests a role for the variations of the CNR1 gene in underlying social reward responsivity. Future studies should aim to replicate this finding with a balanced design in a larger sample, but these preliminary results suggest neural responsivity to emotional and socially rewarding stimuli varies as a function of CNR1 genotype. This has implications for medical conditions involving hypo-responsivity to emotional and social stimuli, such as autism. SN - 0953-816X UR - https://www.unboundmedicine.com/medline/citation/16623851/Variations_in_the_human_cannabinoid_receptor__CNR1__gene_modulate_striatal_responses_to_happy_faces_ L2 - https://doi.org/10.1111/j.1460-9568.2006.04697.x DB - PRIME DP - Unbound Medicine ER -