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[Expression and significance of severe acute respiratory syndrome associated coronavirus (SARS-CoV)-X4 protein in lungs of SARS patients].
Zhonghua Nei Ke Za Zhi. 2006 Mar; 45(3):196-8.ZN

Abstract

OBJECTIVE

To investigate the significance of severe acute respiratory syndrome associated coronavirus (SARS-CoV)-X4 protein expression in lungs of patients with SARS.

METHODS

Pathological features of the lungs from 4 SARS patients were examined and the expression of SARS-CoV-X4 protein in the lungs was evaluated with immunohistochemical staining using specific antibodies against protein X4.

RESULTS

Microscopically, all lungs from 4 cases showed edema, erythrocyte and fibrin exudates in the alveoli, hyperplasia of alveolar epithelium, necrosis, hyaline membrane formation and fibroblast foci. Immunohistochemical stains showed a strong positivity of X4 protein in denudation cells, vascular endothelial cells and also erythrocytes and neutrophils in the alveoli of the lung tissues from the 4 cases.

CONCLUSIONS

Expression of SARS-CoV-X4 protein in the lungs may be involved in the pathogenesis and progression of SARS.

Links

Publisher Full Text

Authors+Show Affiliations

Tan YX
Guangzhou Institute of Respiratory Disease, First Affiliated Hospital, Guangzhou Medical College, Guangzhou 510120, China. yaxiatan@yahoo.com.cn
Chen T
No affiliation info available
Zhong SQ
No affiliation info available
Li YM
No affiliation info available
Chen YY
No affiliation info available
Qiu XY
No affiliation info available
Mo XN
No affiliation info available
Song QS
No affiliation info available
Gan QN
No affiliation info available
Gu YY
No affiliation info available
Mo HY
No affiliation info available
Luo W
No affiliation info available
He XM
No affiliation info available
Liu MC
No affiliation info available
Zhong NS
No affiliation info available

MeSH

AdultAgedHumansImmunohistochemistryLungMaleMiddle AgedSevere Acute Respiratory SyndromeStaining and LabelingViral Matrix ProteinsViral Proteins

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

16624149

Citation

Tan, Ya-xia, et al. "[Expression and Significance of Severe Acute Respiratory Syndrome Associated Coronavirus (SARS-CoV)-X4 Protein in Lungs of SARS Patients]." Zhonghua Nei Ke Za Zhi, vol. 45, no. 3, 2006, pp. 196-8.
Tan YX, Chen T, Zhong SQ, et al. [Expression and significance of severe acute respiratory syndrome associated coronavirus (SARS-CoV)-X4 protein in lungs of SARS patients]. Zhonghua Nei Ke Za Zhi. 2006;45(3):196-8.
Tan, Y. X., Chen, T., Zhong, S. Q., Li, Y. M., Chen, Y. Y., Qiu, X. Y., Mo, X. N., Song, Q. S., Gan, Q. N., Gu, Y. Y., Mo, H. Y., Luo, W., He, X. M., Liu, M. C., & Zhong, N. S. (2006). [Expression and significance of severe acute respiratory syndrome associated coronavirus (SARS-CoV)-X4 protein in lungs of SARS patients]. Zhonghua Nei Ke Za Zhi, 45(3), 196-8.
Tan YX, et al. [Expression and Significance of Severe Acute Respiratory Syndrome Associated Coronavirus (SARS-CoV)-X4 Protein in Lungs of SARS Patients]. Zhonghua Nei Ke Za Zhi. 2006;45(3):196-8. PubMed PMID: 16624149.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Expression and significance of severe acute respiratory syndrome associated coronavirus (SARS-CoV)-X4 protein in lungs of SARS patients]. AU - Tan,Ya-xia, AU - Chen,Tao, AU - Zhong,Shu-qing, AU - Li,Yi-min, AU - Chen,Ying-yu, AU - Qiu,Xiao-yan, AU - Mo,Xiao-ning, AU - Song,Quan-sheng, AU - Gan,Qi-ni, AU - Gu,Ying-ying, AU - Mo,Hong-ying, AU - Luo,Wei, AU - He,Xin-ming, AU - Liu,Mu-chang, AU - Zhong,Nan-shan, PY - 2006/4/21/pubmed PY - 2007/3/7/medline PY - 2006/4/21/entrez SP - 196 EP - 8 JF - Zhonghua nei ke za zhi JO - Zhonghua Nei Ke Za Zhi VL - 45 IS - 3 N2 - OBJECTIVE: To investigate the significance of severe acute respiratory syndrome associated coronavirus (SARS-CoV)-X4 protein expression in lungs of patients with SARS. METHODS: Pathological features of the lungs from 4 SARS patients were examined and the expression of SARS-CoV-X4 protein in the lungs was evaluated with immunohistochemical staining using specific antibodies against protein X4. RESULTS: Microscopically, all lungs from 4 cases showed edema, erythrocyte and fibrin exudates in the alveoli, hyperplasia of alveolar epithelium, necrosis, hyaline membrane formation and fibroblast foci. Immunohistochemical stains showed a strong positivity of X4 protein in denudation cells, vascular endothelial cells and also erythrocytes and neutrophils in the alveoli of the lung tissues from the 4 cases. CONCLUSIONS: Expression of SARS-CoV-X4 protein in the lungs may be involved in the pathogenesis and progression of SARS. SN - 0578-1426 UR - https://www.unboundmedicine.com/medline/citation/16624149/[Expression_and_significance_of_severe_acute_respiratory_syndrome_associated_coronavirus__SARS_CoV__X4_protein_in_lungs_of_SARS_patients]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=0578-1426&year=2006&vol=45&issue=3&fpage=196 DB - PRIME DP - Unbound Medicine ER -