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GABA(A) receptors of hippocampal CA1 regions are involved in the acquisition and expression of morphine-induced place preference.
Eur Neuropsychopharmacol. 2007 Jan; 17(1):24-31.EN

Abstract

In the present study, the effects of bilateral intra-hippocampal CA1 (intra-CA1) injections of GABA(A) receptor agonist and/or antagonist on the acquisition and expression of morphine-induced place preference in male Wistar rats have been investigated. The conditioning treatments with subcutaneous (s.c.) injections of different doses of morphine (0.5-7.5 mg/kg) induced a conditioned place preference (CPP) for the drug-associated place in a dose-dependent manner. Intra-CA1 administration of the GABA(A) receptor agonist, muscimol (0.25, 0.5 and 1 microg/rat) significantly inhibited the morphine (5 mg/kg, s.c.)-induced CPP. Intra-CA1 injections of different doses of the GABA(A) receptor antagonist, bicuculline (0.25, 0.5 and 1 microg/rat), in combination with an ineffective dose of morphine (0.5 mg/kg, s.c.) elicited a significant CPP. However, muscimol or bicuculline by themselves did not elicit any effect on place conditioning. Furthermore, the muscimol-induced inhibition of morphine response was reversed by bicuculline (1 microg/rat, intra-CA1) administration. On the other hand, the bilateral intra-CA1 injections of muscimol (0.25, 0.5 and 1 microg/rat) or bicuculline (0.5, 1 and 2 microg/rat) significantly decreased the expression of morphine-induced CPP. Intra-CA1 administration of different doses of muscimol or bicuculline had no effect on locomotor activity in the testing phase. Our data indicated that the GABA(A) receptors of the hippocampal CA1 regions may play an important role in the acquisition and expression of morphine-induced place preference.

Authors+Show Affiliations

School of Biology, University College of Science, University of Tehran, Tehran, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16624534

Citation

Rezayof, Ameneh, et al. "GABA(A) Receptors of Hippocampal CA1 Regions Are Involved in the Acquisition and Expression of Morphine-induced Place Preference." European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, vol. 17, no. 1, 2007, pp. 24-31.
Rezayof A, Razavi S, Haeri-Rohani A, et al. GABA(A) receptors of hippocampal CA1 regions are involved in the acquisition and expression of morphine-induced place preference. Eur Neuropsychopharmacol. 2007;17(1):24-31.
Rezayof, A., Razavi, S., Haeri-Rohani, A., Rassouli, Y., & Zarrindast, M. R. (2007). GABA(A) receptors of hippocampal CA1 regions are involved in the acquisition and expression of morphine-induced place preference. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, 17(1), 24-31.
Rezayof A, et al. GABA(A) Receptors of Hippocampal CA1 Regions Are Involved in the Acquisition and Expression of Morphine-induced Place Preference. Eur Neuropsychopharmacol. 2007;17(1):24-31. PubMed PMID: 16624534.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - GABA(A) receptors of hippocampal CA1 regions are involved in the acquisition and expression of morphine-induced place preference. AU - Rezayof,Ameneh, AU - Razavi,Samira, AU - Haeri-Rohani,Ali, AU - Rassouli,Yassaman, AU - Zarrindast,Mohammad-Reza, Y1 - 2006/03/06/ PY - 2005/07/09/received PY - 2006/01/29/revised PY - 2006/02/14/accepted PY - 2006/4/21/pubmed PY - 2007/3/7/medline PY - 2006/4/21/entrez SP - 24 EP - 31 JF - European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology JO - Eur Neuropsychopharmacol VL - 17 IS - 1 N2 - In the present study, the effects of bilateral intra-hippocampal CA1 (intra-CA1) injections of GABA(A) receptor agonist and/or antagonist on the acquisition and expression of morphine-induced place preference in male Wistar rats have been investigated. The conditioning treatments with subcutaneous (s.c.) injections of different doses of morphine (0.5-7.5 mg/kg) induced a conditioned place preference (CPP) for the drug-associated place in a dose-dependent manner. Intra-CA1 administration of the GABA(A) receptor agonist, muscimol (0.25, 0.5 and 1 microg/rat) significantly inhibited the morphine (5 mg/kg, s.c.)-induced CPP. Intra-CA1 injections of different doses of the GABA(A) receptor antagonist, bicuculline (0.25, 0.5 and 1 microg/rat), in combination with an ineffective dose of morphine (0.5 mg/kg, s.c.) elicited a significant CPP. However, muscimol or bicuculline by themselves did not elicit any effect on place conditioning. Furthermore, the muscimol-induced inhibition of morphine response was reversed by bicuculline (1 microg/rat, intra-CA1) administration. On the other hand, the bilateral intra-CA1 injections of muscimol (0.25, 0.5 and 1 microg/rat) or bicuculline (0.5, 1 and 2 microg/rat) significantly decreased the expression of morphine-induced CPP. Intra-CA1 administration of different doses of muscimol or bicuculline had no effect on locomotor activity in the testing phase. Our data indicated that the GABA(A) receptors of the hippocampal CA1 regions may play an important role in the acquisition and expression of morphine-induced place preference. SN - 0924-977X UR - https://www.unboundmedicine.com/medline/citation/16624534/GABA_A__receptors_of_hippocampal_CA1_regions_are_involved_in_the_acquisition_and_expression_of_morphine_induced_place_preference_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0924-977X(06)00030-7 DB - PRIME DP - Unbound Medicine ER -