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Effect of a serotonin depleting regimen of 3,4-methylenedioxymethamphetamine (MDMA) on the subsequent stimulation of acetylcholine release in the rat prefrontal cortex.
Brain Res Bull. 2006 Apr 28; 69(4):382-7.BR

Abstract

The amphetamine analog 3,4-methylenedioxymethamphetamine (MDMA) is considered to be selectively neurotoxic to serotonergic nerve terminals. Although the long term effects of MDMA on serotonin (5-HT) terminals have been well studied, other potential neurochemical consequences associated with MDMA-induced 5-HT depletion have been less well investigated. In view of the cognitive impairments in human MDMA abusers and the role of acetylcholine (ACh) in learning and memory, it was of interest to determine the influence of a 5-HT depleting regimen of MDMA on subsequent stimulation of ACh release in the prefrontal cortex (PFC). Male rats received vehicle or MDMA (10 mg/kg, i.p. every 2 h for four injections) and underwent in vivo microdialysis 7 days later to assess the subsequent drug- (e.g., MDMA, 5-HT1A agonist) or stress- (e.g., tail pinch, presence of an intruder rat) induced stimulation of ACh release. The increase in the extracellular concentration of ACh in the PFC produced by MDMA (10 mg/kg, i.p.) was significantly less in rats previously exposed to the neurotoxic regimen of MDMA than that in control animals. In contrast, there was no difference in the magnitude of the stimulation of cortical ACh release elicited by the 5-HT1A agonist, 8-hydroxy-2-(di-n-propyl-amino)tetralin (8-OH-DPAT, 0.3mg/kg, s.c.), tail pinch (30 min) or the presence of an intruder rat (40 min) between control animals and animals previously exposed to a neurotoxic regimen of MDMA. These results suggest that although MDMA-induced 5-HT depletion diminishes subsequent MDMA-induced ACh release, there is little impact on cortical ACh release elicited by the stress of pain or the novelty of an environmental intruder.

Authors+Show Affiliations

College of Pharmacy, University of Cincinnati, 3223 Eden Av., Cincinnati, OH 45267, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16624669

Citation

Nair, S G., and G A. Gudelsky. "Effect of a Serotonin Depleting Regimen of 3,4-methylenedioxymethamphetamine (MDMA) On the Subsequent Stimulation of Acetylcholine Release in the Rat Prefrontal Cortex." Brain Research Bulletin, vol. 69, no. 4, 2006, pp. 382-7.
Nair SG, Gudelsky GA. Effect of a serotonin depleting regimen of 3,4-methylenedioxymethamphetamine (MDMA) on the subsequent stimulation of acetylcholine release in the rat prefrontal cortex. Brain Res Bull. 2006;69(4):382-7.
Nair, S. G., & Gudelsky, G. A. (2006). Effect of a serotonin depleting regimen of 3,4-methylenedioxymethamphetamine (MDMA) on the subsequent stimulation of acetylcholine release in the rat prefrontal cortex. Brain Research Bulletin, 69(4), 382-7.
Nair SG, Gudelsky GA. Effect of a Serotonin Depleting Regimen of 3,4-methylenedioxymethamphetamine (MDMA) On the Subsequent Stimulation of Acetylcholine Release in the Rat Prefrontal Cortex. Brain Res Bull. 2006 Apr 28;69(4):382-7. PubMed PMID: 16624669.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of a serotonin depleting regimen of 3,4-methylenedioxymethamphetamine (MDMA) on the subsequent stimulation of acetylcholine release in the rat prefrontal cortex. AU - Nair,S G, AU - Gudelsky,G A, Y1 - 2006/02/14/ PY - 2005/08/05/received PY - 2005/12/19/revised PY - 2006/01/23/accepted PY - 2006/4/21/pubmed PY - 2006/6/9/medline PY - 2006/4/21/entrez SP - 382 EP - 7 JF - Brain research bulletin JO - Brain Res. Bull. VL - 69 IS - 4 N2 - The amphetamine analog 3,4-methylenedioxymethamphetamine (MDMA) is considered to be selectively neurotoxic to serotonergic nerve terminals. Although the long term effects of MDMA on serotonin (5-HT) terminals have been well studied, other potential neurochemical consequences associated with MDMA-induced 5-HT depletion have been less well investigated. In view of the cognitive impairments in human MDMA abusers and the role of acetylcholine (ACh) in learning and memory, it was of interest to determine the influence of a 5-HT depleting regimen of MDMA on subsequent stimulation of ACh release in the prefrontal cortex (PFC). Male rats received vehicle or MDMA (10 mg/kg, i.p. every 2 h for four injections) and underwent in vivo microdialysis 7 days later to assess the subsequent drug- (e.g., MDMA, 5-HT1A agonist) or stress- (e.g., tail pinch, presence of an intruder rat) induced stimulation of ACh release. The increase in the extracellular concentration of ACh in the PFC produced by MDMA (10 mg/kg, i.p.) was significantly less in rats previously exposed to the neurotoxic regimen of MDMA than that in control animals. In contrast, there was no difference in the magnitude of the stimulation of cortical ACh release elicited by the 5-HT1A agonist, 8-hydroxy-2-(di-n-propyl-amino)tetralin (8-OH-DPAT, 0.3mg/kg, s.c.), tail pinch (30 min) or the presence of an intruder rat (40 min) between control animals and animals previously exposed to a neurotoxic regimen of MDMA. These results suggest that although MDMA-induced 5-HT depletion diminishes subsequent MDMA-induced ACh release, there is little impact on cortical ACh release elicited by the stress of pain or the novelty of an environmental intruder. SN - 0361-9230 UR - https://www.unboundmedicine.com/medline/citation/16624669/Effect_of_a_serotonin_depleting_regimen_of_34_methylenedioxymethamphetamine__MDMA__on_the_subsequent_stimulation_of_acetylcholine_release_in_the_rat_prefrontal_cortex_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0361-9230(06)00044-X DB - PRIME DP - Unbound Medicine ER -