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Association between the Pro12Ala variant of the peroxisome proliferator-activated receptor-gamma2 gene and increased 24-h diastolic blood pressure in obese patients with type II diabetes.
J Hum Hypertens. 2006 Sep; 20(9):684-92.JH

Abstract

The aim of the study was to examine an association between the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor (PPAR)-gamma2 gene and blood pressure values assessed by 24-h ambulatory blood pressure monitoring (ABPM) in obese patients with long-lasting type II diabetes. Two hundred and fourteen obese patients (95 men and 119 women) with above 10-year history of type II diabetes were recruited for the study. In all the patients, ABPM was performed and other parameters, including age, body mass index (BMI), waist/hip ratio (WHR), haemoglobin A1c (HbA(1c)), serum lipids and creatinine were also evaluated. The Pro12Ala polymorphism was analysed by polymerase chain reaction-restriction fragment length polymorphism. Two subgroups of patients were compared: (a) Pro/Pro: homozygotic Pro/Pro (n=154) and (b) Ala: Ala allele carriers (Ala/Ala+Ala/Pro) (n=60). The studied groups were not different when age, BMI, WHR, HbA(1c), lipids, creatinine and frequency of hypertension were compared. A similar ratio of patients from both groups were treated with angiotensin-converting enzyme inhibitors, calcium channel blockers, diuretics, beta-blockers and alpha-blockers. A difference was observed in a mean 24-h (Ala: 71.9+/-8.1 vs Pro/Pro: 69.4+/-7.8 mm Hg, P=0.034) and a mean night time (Ala: 67.1+/-7.8 vs Pro/Pro: 64.5+/-8.4 mm Hg, P=0.025) diastolic blood pressure, which was significantly higher in patients with Ala variant. There was also a trend towards a higher mean daytime diastolic blood pressure in this group. It seems that the Pro12Ala variant is associated with an increased mean 24-h diastolic blood pressure in obese diabetic patients. Different reaction for antihypertensive medication depending on a variant of the PPAR-gamma2 gene should also be considered as a possible cause of the presented results.

Authors+Show Affiliations

Department of Endocrinology, Hypertension and Metabolic Diseases, Pomeranian Medical University, Szczecin, Poland. stefend@sci.pam.szczecin.plNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16625233

Citation

Stefański, A, et al. "Association Between the Pro12Ala Variant of the Peroxisome Proliferator-activated Receptor-gamma2 Gene and Increased 24-h Diastolic Blood Pressure in Obese Patients With Type II Diabetes." Journal of Human Hypertension, vol. 20, no. 9, 2006, pp. 684-92.
Stefański A, Majkowska L, Ciechanowicz A, et al. Association between the Pro12Ala variant of the peroxisome proliferator-activated receptor-gamma2 gene and increased 24-h diastolic blood pressure in obese patients with type II diabetes. J Hum Hypertens. 2006;20(9):684-92.
Stefański, A., Majkowska, L., Ciechanowicz, A., Frankow, M., Safranow, K., Parczewski, M., Moleda, P., & Pilarska, K. (2006). Association between the Pro12Ala variant of the peroxisome proliferator-activated receptor-gamma2 gene and increased 24-h diastolic blood pressure in obese patients with type II diabetes. Journal of Human Hypertension, 20(9), 684-92.
Stefański A, et al. Association Between the Pro12Ala Variant of the Peroxisome Proliferator-activated Receptor-gamma2 Gene and Increased 24-h Diastolic Blood Pressure in Obese Patients With Type II Diabetes. J Hum Hypertens. 2006;20(9):684-92. PubMed PMID: 16625233.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between the Pro12Ala variant of the peroxisome proliferator-activated receptor-gamma2 gene and increased 24-h diastolic blood pressure in obese patients with type II diabetes. AU - Stefański,A, AU - Majkowska,L, AU - Ciechanowicz,A, AU - Frankow,M, AU - Safranow,K, AU - Parczewski,M, AU - Moleda,P, AU - Pilarska,K, Y1 - 2006/04/20/ PY - 2006/4/21/pubmed PY - 2006/12/13/medline PY - 2006/4/21/entrez SP - 684 EP - 92 JF - Journal of human hypertension JO - J Hum Hypertens VL - 20 IS - 9 N2 - The aim of the study was to examine an association between the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor (PPAR)-gamma2 gene and blood pressure values assessed by 24-h ambulatory blood pressure monitoring (ABPM) in obese patients with long-lasting type II diabetes. Two hundred and fourteen obese patients (95 men and 119 women) with above 10-year history of type II diabetes were recruited for the study. In all the patients, ABPM was performed and other parameters, including age, body mass index (BMI), waist/hip ratio (WHR), haemoglobin A1c (HbA(1c)), serum lipids and creatinine were also evaluated. The Pro12Ala polymorphism was analysed by polymerase chain reaction-restriction fragment length polymorphism. Two subgroups of patients were compared: (a) Pro/Pro: homozygotic Pro/Pro (n=154) and (b) Ala: Ala allele carriers (Ala/Ala+Ala/Pro) (n=60). The studied groups were not different when age, BMI, WHR, HbA(1c), lipids, creatinine and frequency of hypertension were compared. A similar ratio of patients from both groups were treated with angiotensin-converting enzyme inhibitors, calcium channel blockers, diuretics, beta-blockers and alpha-blockers. A difference was observed in a mean 24-h (Ala: 71.9+/-8.1 vs Pro/Pro: 69.4+/-7.8 mm Hg, P=0.034) and a mean night time (Ala: 67.1+/-7.8 vs Pro/Pro: 64.5+/-8.4 mm Hg, P=0.025) diastolic blood pressure, which was significantly higher in patients with Ala variant. There was also a trend towards a higher mean daytime diastolic blood pressure in this group. It seems that the Pro12Ala variant is associated with an increased mean 24-h diastolic blood pressure in obese diabetic patients. Different reaction for antihypertensive medication depending on a variant of the PPAR-gamma2 gene should also be considered as a possible cause of the presented results. SN - 0950-9240 UR - https://www.unboundmedicine.com/medline/citation/16625233/Association_between_the_Pro12Ala_variant_of_the_peroxisome_proliferator_activated_receptor_gamma2_gene_and_increased_24_h_diastolic_blood_pressure_in_obese_patients_with_type_II_diabetes_ L2 - https://doi.org/10.1038/sj.jhh.1002040 DB - PRIME DP - Unbound Medicine ER -