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Picrotoxin blocks the anxiolytic- and panicolytic-like effects of sodium valproate in the rat elevated T-maze.
Eur J Pharmacol. 2006 May 10; 537(1-3):72-6.EJ

Abstract

The effect of acute sodium valproate administration, an anxiolytic and putative panicolytic drug, was evaluated in rats tested in the elevated T-maze, an animal model that measures two defensive reactions: avoidance (inhibitory avoidance), related to generalized anxiety, and escape (escape from open arms), related to panic. Additionally, the involvement of gamma-aminobutyric acid (GABA) neurotransmission in sodium valproate effects was studied by picrotoxin co-administration. Sodium valproate (300 mg/kg, intraperitoneally, 30 min before the test) impaired both avoidance latency (time to leave the closed arm) and one-way escape (latency to enter the closed arm) indicating anxiolytic and panicolytic effects, respectively. Pre-treatment with picrotoxin (0.5 mg/kg, intraperitoneally, 5 min before sodium valproate administration) blocked the effects of sodium valproate on inhibitory avoidance and one-way escape. No locomotor effect was seen in the open-field. These data suggest that sodium valproate exerts anxiolytic-like and panicolytic-like effects in the elevated T-maze and that these effects were mediated by picrotoxin-sensitive GABA type A receptors.

Authors+Show Affiliations

Dombrowski PA
Laboratório de Fisiologia e Farmacologia do Sistema Nervoso Central, Departamento de Farmacologia, Setor de Ciências Biológicas, Universidade Federal do Paraná, Centro Politécnico C.P. 19031, 81540-990 Curitiba, PR, Brazil.
Fernandes LH
No affiliation info available
Andreatini R
No affiliation info available

MeSH

AnimalsAnti-Anxiety AgentsAnxietyAvoidance LearningEscape ReactionGABA AntagonistsMaleMotor ActivityPanicPicrotoxinRatsRats, WistarValproic Acid

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16626689

Citation

Dombrowski, Patrícia A., et al. "Picrotoxin Blocks the Anxiolytic- and Panicolytic-like Effects of Sodium Valproate in the Rat Elevated T-maze." European Journal of Pharmacology, vol. 537, no. 1-3, 2006, pp. 72-6.
Dombrowski PA, Fernandes LH, Andreatini R. Picrotoxin blocks the anxiolytic- and panicolytic-like effects of sodium valproate in the rat elevated T-maze. Eur J Pharmacol. 2006;537(1-3):72-6.
Dombrowski, P. A., Fernandes, L. H., & Andreatini, R. (2006). Picrotoxin blocks the anxiolytic- and panicolytic-like effects of sodium valproate in the rat elevated T-maze. European Journal of Pharmacology, 537(1-3), 72-6.
Dombrowski PA, Fernandes LH, Andreatini R. Picrotoxin Blocks the Anxiolytic- and Panicolytic-like Effects of Sodium Valproate in the Rat Elevated T-maze. Eur J Pharmacol. 2006 May 10;537(1-3):72-6. PubMed PMID: 16626689.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Picrotoxin blocks the anxiolytic- and panicolytic-like effects of sodium valproate in the rat elevated T-maze. AU - Dombrowski,Patrícia A, AU - Fernandes,Lineane H, AU - Andreatini,Roberto, Y1 - 2006/03/24/ PY - 2005/12/30/received PY - 2006/03/13/revised PY - 2006/03/15/accepted PY - 2006/4/22/pubmed PY - 2006/8/12/medline PY - 2006/4/22/entrez SP - 72 EP - 6 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 537 IS - 1-3 N2 - The effect of acute sodium valproate administration, an anxiolytic and putative panicolytic drug, was evaluated in rats tested in the elevated T-maze, an animal model that measures two defensive reactions: avoidance (inhibitory avoidance), related to generalized anxiety, and escape (escape from open arms), related to panic. Additionally, the involvement of gamma-aminobutyric acid (GABA) neurotransmission in sodium valproate effects was studied by picrotoxin co-administration. Sodium valproate (300 mg/kg, intraperitoneally, 30 min before the test) impaired both avoidance latency (time to leave the closed arm) and one-way escape (latency to enter the closed arm) indicating anxiolytic and panicolytic effects, respectively. Pre-treatment with picrotoxin (0.5 mg/kg, intraperitoneally, 5 min before sodium valproate administration) blocked the effects of sodium valproate on inhibitory avoidance and one-way escape. No locomotor effect was seen in the open-field. These data suggest that sodium valproate exerts anxiolytic-like and panicolytic-like effects in the elevated T-maze and that these effects were mediated by picrotoxin-sensitive GABA type A receptors. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/16626689/Picrotoxin_blocks_the_anxiolytic__and_panicolytic_like_effects_of_sodium_valproate_in_the_rat_elevated_T_maze_ DB - PRIME DP - Unbound Medicine ER -