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Nicotine-induced conditioned taste aversion in the rat: effects of ethanol.
Eur J Pharmacol. 2006 May 10; 537(1-3):99-105.EJ

Abstract

It has been shown that small doses of ethanol antagonise the discriminative stimulus properties of nicotine in the rat. The aim of the present study was to evaluate whether ethanol could antagonise the aversive stimulus effects of nicotine. Wistar rats were trained to associate nicotine injections with a novel tasting fluid (0.1% saccharin) in the conditioned taste aversion procedure. Nicotine (0.3 mg/kg, s.c.) was injected 5 min after the end of a 20-min exposure to the saccharin solution. Ethanol (0.25-0.5 g/kg, i.p.) was administered 5 or 50 min before nicotine. In general, ethanol did not inhibit nicotine-induced conditioned taste aversion. Contrary to the findings in drug discrimination studies, a slight but significant enhancement of nicotine-induced taste aversion conditioning was observed after ethanol pre-treatment. Blood ethanol levels were measured in a separate group of rats. Maximal blood ethanol levels after i.p. administration of 0.25 or 0.5 g/kg ethanol exceeded 20 and 80 mg%, respectively. Concluding, the present results may indicate that ethanol does not attenuate nicotine-induced conditioned taste aversion in the rat.

Authors+Show Affiliations

Department of Pharmacology, Institute of Psychiatry and Neurology, 9 Sobieskiego St., PL-02957, Warsaw, Poland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16626692

Citation

Korkosz, Agnieszka, et al. "Nicotine-induced Conditioned Taste Aversion in the Rat: Effects of Ethanol." European Journal of Pharmacology, vol. 537, no. 1-3, 2006, pp. 99-105.
Korkosz A, Scinska A, Taracha E, et al. Nicotine-induced conditioned taste aversion in the rat: effects of ethanol. Eur J Pharmacol. 2006;537(1-3):99-105.
Korkosz, A., Scinska, A., Taracha, E., Plaznik, A., Kukwa, A., Kostowski, W., & Bienkowski, P. (2006). Nicotine-induced conditioned taste aversion in the rat: effects of ethanol. European Journal of Pharmacology, 537(1-3), 99-105.
Korkosz A, et al. Nicotine-induced Conditioned Taste Aversion in the Rat: Effects of Ethanol. Eur J Pharmacol. 2006 May 10;537(1-3):99-105. PubMed PMID: 16626692.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nicotine-induced conditioned taste aversion in the rat: effects of ethanol. AU - Korkosz,Agnieszka, AU - Scinska,Anna, AU - Taracha,Ewa, AU - Plaznik,Adam, AU - Kukwa,Andrzej, AU - Kostowski,Wojciech, AU - Bienkowski,Przemyslaw, Y1 - 2006/03/20/ PY - 2005/08/15/received PY - 2006/01/03/revised PY - 2006/03/13/accepted PY - 2006/4/22/pubmed PY - 2006/8/12/medline PY - 2006/4/22/entrez SP - 99 EP - 105 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 537 IS - 1-3 N2 - It has been shown that small doses of ethanol antagonise the discriminative stimulus properties of nicotine in the rat. The aim of the present study was to evaluate whether ethanol could antagonise the aversive stimulus effects of nicotine. Wistar rats were trained to associate nicotine injections with a novel tasting fluid (0.1% saccharin) in the conditioned taste aversion procedure. Nicotine (0.3 mg/kg, s.c.) was injected 5 min after the end of a 20-min exposure to the saccharin solution. Ethanol (0.25-0.5 g/kg, i.p.) was administered 5 or 50 min before nicotine. In general, ethanol did not inhibit nicotine-induced conditioned taste aversion. Contrary to the findings in drug discrimination studies, a slight but significant enhancement of nicotine-induced taste aversion conditioning was observed after ethanol pre-treatment. Blood ethanol levels were measured in a separate group of rats. Maximal blood ethanol levels after i.p. administration of 0.25 or 0.5 g/kg ethanol exceeded 20 and 80 mg%, respectively. Concluding, the present results may indicate that ethanol does not attenuate nicotine-induced conditioned taste aversion in the rat. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/16626692/Nicotine_induced_conditioned_taste_aversion_in_the_rat:_effects_of_ethanol_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(06)00279-2 DB - PRIME DP - Unbound Medicine ER -