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Combined antioxidant therapy reduces pain and improves quality of life in chronic pancreatitis.
J Gastrointest Surg 2006; 10(4):499-503JG

Abstract

Patients with chronic pancreatitis (CP) typically suffer intractable abdominal pain that is resistant to most analgesic strategies. Recent research indicates that the pain of CP may be in part due to oxygen free radical induced pancreatic damage. Using a randomized, double-blind, placebo-controlled crossover trial, we evaluated the efficacy of a combined antioxidant preparation in the management of CP. Patients with confirmed chronic pancreatitis (N = 36) were randomized to receive treatment with either Antox, which contains the antioxidants selenium, betacarotene, L-methionine, and vitamins C and E, or placebo for 10 weeks. Each group of patients then switched to receive the alternative treatment for a further 10 weeks. Markers of antioxidant status were measured by blood sampling, whereas quality of life and pain were assessed using the SF-36 questionnaire. Nineteen patients completed the full 20 weeks of treatment. Treatment with Antox was associated with significant improvements in quality of life in terms of pain (+17 antioxidant vs. -7 placebo), physical (+9 vs. -3) and social functioning (+8 vs. -7), and general health perception (+10 vs. -3). We conclude that treatment with antioxidants may improve quality of life and reduce pain in patients suffering from chronic pancreatitis.

Authors+Show Affiliations

Department of Surgery, Royal Victoria Hospital, Belfast, Northern Ireland, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16627214

Citation

Kirk, Gareth R., et al. "Combined Antioxidant Therapy Reduces Pain and Improves Quality of Life in Chronic Pancreatitis." Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract, vol. 10, no. 4, 2006, pp. 499-503.
Kirk GR, White JS, McKie L, et al. Combined antioxidant therapy reduces pain and improves quality of life in chronic pancreatitis. J Gastrointest Surg. 2006;10(4):499-503.
Kirk, G. R., White, J. S., McKie, L., Stevenson, M., Young, I., Clements, W. D., & Rowlands, B. J. (2006). Combined antioxidant therapy reduces pain and improves quality of life in chronic pancreatitis. Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract, 10(4), pp. 499-503.
Kirk GR, et al. Combined Antioxidant Therapy Reduces Pain and Improves Quality of Life in Chronic Pancreatitis. J Gastrointest Surg. 2006;10(4):499-503. PubMed PMID: 16627214.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combined antioxidant therapy reduces pain and improves quality of life in chronic pancreatitis. AU - Kirk,Gareth R, AU - White,Jonathan S, AU - McKie,Lloyd, AU - Stevenson,Mike, AU - Young,Ian, AU - Clements,W D Barry, AU - Rowlands,Brian J, PY - 2005/05/29/received PY - 2005/08/27/accepted PY - 2006/4/22/pubmed PY - 2006/10/21/medline PY - 2006/4/22/entrez SP - 499 EP - 503 JF - Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract JO - J. Gastrointest. Surg. VL - 10 IS - 4 N2 - Patients with chronic pancreatitis (CP) typically suffer intractable abdominal pain that is resistant to most analgesic strategies. Recent research indicates that the pain of CP may be in part due to oxygen free radical induced pancreatic damage. Using a randomized, double-blind, placebo-controlled crossover trial, we evaluated the efficacy of a combined antioxidant preparation in the management of CP. Patients with confirmed chronic pancreatitis (N = 36) were randomized to receive treatment with either Antox, which contains the antioxidants selenium, betacarotene, L-methionine, and vitamins C and E, or placebo for 10 weeks. Each group of patients then switched to receive the alternative treatment for a further 10 weeks. Markers of antioxidant status were measured by blood sampling, whereas quality of life and pain were assessed using the SF-36 questionnaire. Nineteen patients completed the full 20 weeks of treatment. Treatment with Antox was associated with significant improvements in quality of life in terms of pain (+17 antioxidant vs. -7 placebo), physical (+9 vs. -3) and social functioning (+8 vs. -7), and general health perception (+10 vs. -3). We conclude that treatment with antioxidants may improve quality of life and reduce pain in patients suffering from chronic pancreatitis. SN - 1091-255X UR - https://www.unboundmedicine.com/medline/citation/16627214/Combined_antioxidant_therapy_reduces_pain_and_improves_quality_of_life_in_chronic_pancreatitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1091-255X(05)00669-4 DB - PRIME DP - Unbound Medicine ER -