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Detection of alpha-thalassemia in beta-thalassemia carriers and prevention of Hb Bart's hydrops fetalis through prenatal screening.
Haematologica. 2006 May; 91(5):649-51.H

Abstract

The aim of this study was to detect alpha-thalassemia in beta-thalassemia carriers during prenatal screening. During a 12-year prenatal screening program, a total of 158 couples (3.2%) were diagnosed to be the discordant alpha- and beta-thalassemia carriers. Of the 158 beta-thalassemia partners, seven (4.4%) were found to have co-inheritance of alpha0-thalassemia, and three (1.9%) found to have co-inheritance of alpha(+)-thalassemia. Three pregnancies affected with Hb Bart's hydrops fetalis were terminated in the 158 couples. The results showed that molecular analysis must be used for accurate diagnosis of double heterozygotes in couples presumed to be discordant for alpha- and beta-thalassemia on hematologic testing.

Authors+Show Affiliations

Prenatal Diagnostic Center, Guangzhou Maternal & Neonatal Hospital, Guangzhou Medical College, Guangzhou, Guangdong, China. dongzhi3@yahoo.com.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16627247

Citation

Li, Dongzhi, et al. "Detection of Alpha-thalassemia in Beta-thalassemia Carriers and Prevention of Hb Bart's Hydrops Fetalis Through Prenatal Screening." Haematologica, vol. 91, no. 5, 2006, pp. 649-51.
Li D, Liao C, Li J, et al. Detection of alpha-thalassemia in beta-thalassemia carriers and prevention of Hb Bart's hydrops fetalis through prenatal screening. Haematologica. 2006;91(5):649-51.
Li, D., Liao, C., Li, J., Xie, X., Huang, Y., & Zhong, H. (2006). Detection of alpha-thalassemia in beta-thalassemia carriers and prevention of Hb Bart's hydrops fetalis through prenatal screening. Haematologica, 91(5), 649-51.
Li D, et al. Detection of Alpha-thalassemia in Beta-thalassemia Carriers and Prevention of Hb Bart's Hydrops Fetalis Through Prenatal Screening. Haematologica. 2006;91(5):649-51. PubMed PMID: 16627247.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detection of alpha-thalassemia in beta-thalassemia carriers and prevention of Hb Bart's hydrops fetalis through prenatal screening. AU - Li,Dongzhi, AU - Liao,Can, AU - Li,Jian, AU - Xie,Xingmei, AU - Huang,Yining, AU - Zhong,Huizhu, PY - 2005/11/21/received PY - 2006/03/06/accepted PY - 2006/4/22/pubmed PY - 2006/8/25/medline PY - 2006/4/22/entrez SP - 649 EP - 51 JF - Haematologica JO - Haematologica VL - 91 IS - 5 N2 - The aim of this study was to detect alpha-thalassemia in beta-thalassemia carriers during prenatal screening. During a 12-year prenatal screening program, a total of 158 couples (3.2%) were diagnosed to be the discordant alpha- and beta-thalassemia carriers. Of the 158 beta-thalassemia partners, seven (4.4%) were found to have co-inheritance of alpha0-thalassemia, and three (1.9%) found to have co-inheritance of alpha(+)-thalassemia. Three pregnancies affected with Hb Bart's hydrops fetalis were terminated in the 158 couples. The results showed that molecular analysis must be used for accurate diagnosis of double heterozygotes in couples presumed to be discordant for alpha- and beta-thalassemia on hematologic testing. SN - 1592-8721 UR - https://www.unboundmedicine.com/medline/citation/16627247/Detection_of_alpha_thalassemia_in_beta_thalassemia_carriers_and_prevention_of_Hb_Bart's_hydrops_fetalis_through_prenatal_screening_ L2 - http://www.haematologica.org/cgi/pmidlookup?view=long&pmid=16627247 DB - PRIME DP - Unbound Medicine ER -