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Host species barriers to influenza virus infections.
Science 2006; 312(5772):394-7Sci

Abstract

Most emerging infectious diseases in humans originate from animal reservoirs; to contain and eradicate these diseases we need to understand how and why some pathogens become capable of crossing host species barriers. Influenza virus illustrates the interaction of factors that limit the transmission and subsequent establishment of an infection in a novel host species. Influenza species barriers can be categorized into virus-host interactions occurring within individuals and host-host interactions, either within or between species, that affect transmission between individuals. Viral evolution can help surmount species barriers, principally by affecting virus-host interactions; however, evolving the capability for sustained transmission in a new host species represents a major adaptive challenge because the number of mutations required is often large.

Authors+Show Affiliations

Department of Virology, Erasmus Medical Center, 3015 GE Rotterdam, Netherlands. t.kuiken@erasmusmc.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16627737

Citation

Kuiken, Thijs, et al. "Host Species Barriers to Influenza Virus Infections." Science (New York, N.Y.), vol. 312, no. 5772, 2006, pp. 394-7.
Kuiken T, Holmes EC, McCauley J, et al. Host species barriers to influenza virus infections. Science. 2006;312(5772):394-7.
Kuiken, T., Holmes, E. C., McCauley, J., Rimmelzwaan, G. F., Williams, C. S., & Grenfell, B. T. (2006). Host species barriers to influenza virus infections. Science (New York, N.Y.), 312(5772), pp. 394-7.
Kuiken T, et al. Host Species Barriers to Influenza Virus Infections. Science. 2006 Apr 21;312(5772):394-7. PubMed PMID: 16627737.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Host species barriers to influenza virus infections. AU - Kuiken,Thijs, AU - Holmes,Edward C, AU - McCauley,John, AU - Rimmelzwaan,Guus F, AU - Williams,Catherine S, AU - Grenfell,Bryan T, PY - 2006/4/22/pubmed PY - 2006/5/4/medline PY - 2006/4/22/entrez SP - 394 EP - 7 JF - Science (New York, N.Y.) JO - Science VL - 312 IS - 5772 N2 - Most emerging infectious diseases in humans originate from animal reservoirs; to contain and eradicate these diseases we need to understand how and why some pathogens become capable of crossing host species barriers. Influenza virus illustrates the interaction of factors that limit the transmission and subsequent establishment of an infection in a novel host species. Influenza species barriers can be categorized into virus-host interactions occurring within individuals and host-host interactions, either within or between species, that affect transmission between individuals. Viral evolution can help surmount species barriers, principally by affecting virus-host interactions; however, evolving the capability for sustained transmission in a new host species represents a major adaptive challenge because the number of mutations required is often large. SN - 1095-9203 UR - https://www.unboundmedicine.com/medline/citation/16627737/Host_species_barriers_to_influenza_virus_infections_ L2 - http://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=16627737 DB - PRIME DP - Unbound Medicine ER -