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Effect of rat-to-mouse bioartificial pancreas xenotransplantation on diabetic renal damage and survival.
Pancreas. 2006 Apr; 32(3):249-57.P

Abstract

OBJECTIVE

Diabetic nephropathy is a life-threatening complication of diabetes mellitus. Bioartificial pancreas transplantation is becoming a therapeutic option for diabetes mellitus as it protects both allogeneic and xenogeneic islets from the host immune system. This study was undertaken to determine the effectiveness of bioartificial pancreas transplantation to improve or prevent diabetic renal damage.

METHODS

Approximately 800 rat islets were macroencapsulated in polyvinyl alcohol gel and then transplanted into the peritoneal cavity of diabetic mice (transplantation group [Tx group]). Diabetic mice transplanted with a capsule without islets served as a sham operation group. After transplantation, the following data were collected: survival, body weight, blood glucose, blood urea nitrogen, serum creatinine levels, urinalysis, water intake, and histological changes in the kidney.

RESULTS

There was a significant improvement in survival, blood glucose, blood urea nitrogen, and creatinine in the Tx group compared with the sham operation group. No remarkable changes were seen in urinary parameters between the 2 groups, and there was also no significant difference in water intake. Histological examination revealed that mesangial matrix expansion was decreased in the Tx group.

CONCLUSIONS

This study demonstrated that polyvinyl alcohol gel bioartificial pancreas transplantation can protect the kidney from diabetic damage.

Authors+Show Affiliations

Department of Organ Reconstruction and Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16628079

Citation

Sakata, Naoaki, et al. "Effect of Rat-to-mouse Bioartificial Pancreas Xenotransplantation On Diabetic Renal Damage and Survival." Pancreas, vol. 32, no. 3, 2006, pp. 249-57.
Sakata N, Gu Y, Qi M, et al. Effect of rat-to-mouse bioartificial pancreas xenotransplantation on diabetic renal damage and survival. Pancreas. 2006;32(3):249-57.
Sakata, N., Gu, Y., Qi, M., Yamamoto, C., Hiura, A., Sumi, S., Sunamura, M., Matsuno, S., & Inoue, K. (2006). Effect of rat-to-mouse bioartificial pancreas xenotransplantation on diabetic renal damage and survival. Pancreas, 32(3), 249-57.
Sakata N, et al. Effect of Rat-to-mouse Bioartificial Pancreas Xenotransplantation On Diabetic Renal Damage and Survival. Pancreas. 2006;32(3):249-57. PubMed PMID: 16628079.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of rat-to-mouse bioartificial pancreas xenotransplantation on diabetic renal damage and survival. AU - Sakata,Naoaki, AU - Gu,Yuanjun, AU - Qi,Meirigeng, AU - Yamamoto,Chidzuru, AU - Hiura,Akihito, AU - Sumi,Shoichiro, AU - Sunamura,Makoto, AU - Matsuno,Seiki, AU - Inoue,Kazutomo, PY - 2006/4/22/pubmed PY - 2006/5/23/medline PY - 2006/4/22/entrez SP - 249 EP - 57 JF - Pancreas JO - Pancreas VL - 32 IS - 3 N2 - OBJECTIVE: Diabetic nephropathy is a life-threatening complication of diabetes mellitus. Bioartificial pancreas transplantation is becoming a therapeutic option for diabetes mellitus as it protects both allogeneic and xenogeneic islets from the host immune system. This study was undertaken to determine the effectiveness of bioartificial pancreas transplantation to improve or prevent diabetic renal damage. METHODS: Approximately 800 rat islets were macroencapsulated in polyvinyl alcohol gel and then transplanted into the peritoneal cavity of diabetic mice (transplantation group [Tx group]). Diabetic mice transplanted with a capsule without islets served as a sham operation group. After transplantation, the following data were collected: survival, body weight, blood glucose, blood urea nitrogen, serum creatinine levels, urinalysis, water intake, and histological changes in the kidney. RESULTS: There was a significant improvement in survival, blood glucose, blood urea nitrogen, and creatinine in the Tx group compared with the sham operation group. No remarkable changes were seen in urinary parameters between the 2 groups, and there was also no significant difference in water intake. Histological examination revealed that mesangial matrix expansion was decreased in the Tx group. CONCLUSIONS: This study demonstrated that polyvinyl alcohol gel bioartificial pancreas transplantation can protect the kidney from diabetic damage. SN - 1536-4828 UR - https://www.unboundmedicine.com/medline/citation/16628079/Effect_of_rat_to_mouse_bioartificial_pancreas_xenotransplantation_on_diabetic_renal_damage_and_survival_ L2 - https://doi.org/10.1097/01.mpa.0000203959.31877.8c DB - PRIME DP - Unbound Medicine ER -