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[Characteristics of the action potentials and the underlying ionic mechanisms in the cardiomyocytes from rabbit pulmonary vein sleeves].
Sheng Li Xue Bao. 2006 Apr 25; 58(2):129-35.SL

Abstract

To investigate the characteristics of action potentials and their ionic mechanism in cardiomyocytes from rabbit pulmonary vein sleeves (PVC), and to compare them with those in left atrial cardiomyocytes (LAC), the technique of whole-cell patch clamp was applied. We used current-clamp technique to record action potentials, and voltage-clamp technique to record ionic currents. PVC had longer action potential duration (APD) than LAC, and therefore a second plateau response could be induced easily, suggesting a strong tendency of early afterdepolarization (EAD) genesis in PVC. Non-selective cation current (I(NSCC)) was first recorded in both LAC and PVC. This I(NSCC)was permeable to K(+), Na(+) and Cs(+), sensitive to GdCl3 but not sensitive to 4-AP. The current densities of inward rectifier potassium current (I(K1)), transient outward potassium current (I(To)) and I(NSCC) were all significantly less in PVC than those in LAC. These differences in repolarizing ionic currents between PVC and LAC form a basis of the differences in their action potential configurations and might be an important ionic mechanism of the arrhythmogenic characteristics of pulmonary vein muscle sleeves.

Authors+Show Affiliations

Heart Center, Beijing Chaoyang Hospital Affiliated to the Capital University of Medical Sciences, Beijing 100020, China. dhy_121148@sohu.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

16628359

Citation

Ding, Huai-Yu, et al. "[Characteristics of the Action Potentials and the Underlying Ionic Mechanisms in the Cardiomyocytes From Rabbit Pulmonary Vein Sleeves]." Sheng Li Xue Bao : [Acta Physiologica Sinica], vol. 58, no. 2, 2006, pp. 129-35.
Ding HY, Yang XC, Liu XL, et al. [Characteristics of the action potentials and the underlying ionic mechanisms in the cardiomyocytes from rabbit pulmonary vein sleeves]. Sheng Li Xue Bao. 2006;58(2):129-35.
Ding, H. Y., Yang, X. C., Liu, X. L., Liu, T. F., & Bao, R. F. (2006). [Characteristics of the action potentials and the underlying ionic mechanisms in the cardiomyocytes from rabbit pulmonary vein sleeves]. Sheng Li Xue Bao : [Acta Physiologica Sinica], 58(2), 129-35.
Ding HY, et al. [Characteristics of the Action Potentials and the Underlying Ionic Mechanisms in the Cardiomyocytes From Rabbit Pulmonary Vein Sleeves]. Sheng Li Xue Bao. 2006 Apr 25;58(2):129-35. PubMed PMID: 16628359.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Characteristics of the action potentials and the underlying ionic mechanisms in the cardiomyocytes from rabbit pulmonary vein sleeves]. AU - Ding,Huai-Yu, AU - Yang,Xin-Chun, AU - Liu,Xiu-Lan, AU - Liu,Tai-Feng, AU - Bao,Rong-Feng, PY - 2006/4/22/pubmed PY - 2013/12/20/medline PY - 2006/4/22/entrez SP - 129 EP - 35 JF - Sheng li xue bao : [Acta physiologica Sinica] JO - Sheng Li Xue Bao VL - 58 IS - 2 N2 - To investigate the characteristics of action potentials and their ionic mechanism in cardiomyocytes from rabbit pulmonary vein sleeves (PVC), and to compare them with those in left atrial cardiomyocytes (LAC), the technique of whole-cell patch clamp was applied. We used current-clamp technique to record action potentials, and voltage-clamp technique to record ionic currents. PVC had longer action potential duration (APD) than LAC, and therefore a second plateau response could be induced easily, suggesting a strong tendency of early afterdepolarization (EAD) genesis in PVC. Non-selective cation current (I(NSCC)) was first recorded in both LAC and PVC. This I(NSCC)was permeable to K(+), Na(+) and Cs(+), sensitive to GdCl3 but not sensitive to 4-AP. The current densities of inward rectifier potassium current (I(K1)), transient outward potassium current (I(To)) and I(NSCC) were all significantly less in PVC than those in LAC. These differences in repolarizing ionic currents between PVC and LAC form a basis of the differences in their action potential configurations and might be an important ionic mechanism of the arrhythmogenic characteristics of pulmonary vein muscle sleeves. SN - 0371-0874 UR - https://www.unboundmedicine.com/medline/citation/16628359/[Characteristics_of_the_action_potentials_and_the_underlying_ionic_mechanisms_in_the_cardiomyocytes_from_rabbit_pulmonary_vein_sleeves]_ DB - PRIME DP - Unbound Medicine ER -