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Diagnosis and treatment of cluster headache.
Semin Neurol. 2006 Apr; 26(2):242-59.SN

Abstract

Cluster headache is an uncommon yet distinctive neurovascular syndrome occurring in either episodic or chronic patterns. The most unique feature of cluster headache is the unmistakable circadian and circannual periodicity. The attacks are stereotypical, that is, of extreme intensity, of short duration, occurring unilaterally, and associated with robust signs and symptoms of autonomic dysfunction. Unlike migraine, during an attack the patient with cluster headache often paces about. Attacks frequently occur at night, awakening the patient from sleep. Although the pathophysiology of cluster headache remains to be fully elucidated, several seminal observations have recently been made. The medical treatment of cluster headache includes acute, transitional, and maintenance prophylaxis. Agents used for acute therapy include inhalation of oxygen and triptans, such as sumatriptan, and dihydroergotamine. Transitional prophylaxis refers to the short-term use of fast-acting agents. This typically involves either corticosteroids or ergotamine derivatives. The mainstay of prophylactic therapy is verapamil. Lithium, divalproex sodium, or topiramate may also be useful. As the sophistication of functional neuroimaging increases, so too will our ability to better understand the anatomic and metabolic perturbations that underlie cluster headache.

Authors+Show Affiliations

Department of Neurology, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, FL 32224, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16628535

Citation

Capobianco, David J., and David W. Dodick. "Diagnosis and Treatment of Cluster Headache." Seminars in Neurology, vol. 26, no. 2, 2006, pp. 242-59.
Capobianco DJ, Dodick DW. Diagnosis and treatment of cluster headache. Semin Neurol. 2006;26(2):242-59.
Capobianco, D. J., & Dodick, D. W. (2006). Diagnosis and treatment of cluster headache. Seminars in Neurology, 26(2), 242-59.
Capobianco DJ, Dodick DW. Diagnosis and Treatment of Cluster Headache. Semin Neurol. 2006;26(2):242-59. PubMed PMID: 16628535.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnosis and treatment of cluster headache. AU - Capobianco,David J, AU - Dodick,David W, PY - 2006/4/22/pubmed PY - 2006/7/14/medline PY - 2006/4/22/entrez SP - 242 EP - 59 JF - Seminars in neurology JO - Semin Neurol VL - 26 IS - 2 N2 - Cluster headache is an uncommon yet distinctive neurovascular syndrome occurring in either episodic or chronic patterns. The most unique feature of cluster headache is the unmistakable circadian and circannual periodicity. The attacks are stereotypical, that is, of extreme intensity, of short duration, occurring unilaterally, and associated with robust signs and symptoms of autonomic dysfunction. Unlike migraine, during an attack the patient with cluster headache often paces about. Attacks frequently occur at night, awakening the patient from sleep. Although the pathophysiology of cluster headache remains to be fully elucidated, several seminal observations have recently been made. The medical treatment of cluster headache includes acute, transitional, and maintenance prophylaxis. Agents used for acute therapy include inhalation of oxygen and triptans, such as sumatriptan, and dihydroergotamine. Transitional prophylaxis refers to the short-term use of fast-acting agents. This typically involves either corticosteroids or ergotamine derivatives. The mainstay of prophylactic therapy is verapamil. Lithium, divalproex sodium, or topiramate may also be useful. As the sophistication of functional neuroimaging increases, so too will our ability to better understand the anatomic and metabolic perturbations that underlie cluster headache. SN - 0271-8235 UR - https://www.unboundmedicine.com/medline/citation/16628535/Diagnosis_and_treatment_of_cluster_headache_ L2 - https://www.thieme-connect.com/DOI/DOI?10.1055/s-2006-939925 DB - PRIME DP - Unbound Medicine ER -