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Gastrointestinal endoscopic findings in men with unexplained anemia and low normal ferritin values.
Am J Hematol. 2006 May; 81(5):324-7.AJ

Abstract

BACKGROUND

Most practice guidelines recommend endoscopic evaluation of the gastrointestinal (GI) tract in men and postmenopausal women with anemia and a serum ferritin less than 20-40 ng/ml. The diagnostic yield of endoscopy in patients with anemia, no GI symptoms or signs, and low normal ferritin is not known.

OBJECTIVE

The aim of this study was to investigate the yield of upper and lower GI endoscopic evaluations in anemic patients with ferritin levels between 40 and 100 ng/ml.

DESIGN

A retrospective review of patients' charts was conducted.

SUBJECTS AND METHODS

Patients at the Veterans Affairs Connecticut Healthcare System who underwent GI endoscopic evaluation for the sole indication of anemia and ferritin in the low normal range (40-100 ng/ml) were included in this study.

MEASUREMENTS

Incidence of pathology of the upper and lower GI tract was determined.

RESULTS

We identified 54 male patients who had a ferritin level of 40-100 ng/ml and no GI symptoms or known GI bleeding. Upper GI findings (malignancy, peptic ulcers, Helicobacter pylori gastritis, arteriovenous malformations) were found in 14/47 cases (30%). Lower gastrointestinal findings, including large tubular adenomas and arteriovenous malformation, were identified in 3/53 cases (6.7%).

CONCLUSION

Our study supports GI endoscopy in anemic patients with ferritin between 40 and 100 ng/ml, even in the absence of GI symptoms or documented bleeding.

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Authors+Show Affiliations

Wang SA
Department of Pathology, University of Massachusetts Medical Center, Worcester, Massachusetts, USA.
Fadare O
No affiliation info available
Nagar A
No affiliation info available
Shafi NQ
No affiliation info available
Rose MG
No affiliation info available

MeSH

AdultAgedAged, 80 and overAnemia, Iron-DeficiencyColonoscopyEndoscopy, GastrointestinalFerritinsGastrointestinal DiseasesHumansLower Gastrointestinal TractMaleMedical RecordsMiddle AgedRetrospective StudiesUpper Gastrointestinal Tract

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16628728

Citation

Wang, Sa A., et al. "Gastrointestinal Endoscopic Findings in Men With Unexplained Anemia and Low Normal Ferritin Values." American Journal of Hematology, vol. 81, no. 5, 2006, pp. 324-7.
Wang SA, Fadare O, Nagar A, et al. Gastrointestinal endoscopic findings in men with unexplained anemia and low normal ferritin values. Am J Hematol. 2006;81(5):324-7.
Wang, S. A., Fadare, O., Nagar, A., Shafi, N. Q., & Rose, M. G. (2006). Gastrointestinal endoscopic findings in men with unexplained anemia and low normal ferritin values. American Journal of Hematology, 81(5), 324-7.
Wang SA, et al. Gastrointestinal Endoscopic Findings in Men With Unexplained Anemia and Low Normal Ferritin Values. Am J Hematol. 2006;81(5):324-7. PubMed PMID: 16628728.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastrointestinal endoscopic findings in men with unexplained anemia and low normal ferritin values. AU - Wang,Sa A, AU - Fadare,Oluwole, AU - Nagar,Anil, AU - Shafi,Nelofar Q, AU - Rose,Michal G, PY - 2006/4/22/pubmed PY - 2006/6/2/medline PY - 2006/4/22/entrez SP - 324 EP - 7 JF - American journal of hematology JO - Am J Hematol VL - 81 IS - 5 N2 - BACKGROUND: Most practice guidelines recommend endoscopic evaluation of the gastrointestinal (GI) tract in men and postmenopausal women with anemia and a serum ferritin less than 20-40 ng/ml. The diagnostic yield of endoscopy in patients with anemia, no GI symptoms or signs, and low normal ferritin is not known. OBJECTIVE: The aim of this study was to investigate the yield of upper and lower GI endoscopic evaluations in anemic patients with ferritin levels between 40 and 100 ng/ml. DESIGN: A retrospective review of patients' charts was conducted. SUBJECTS AND METHODS: Patients at the Veterans Affairs Connecticut Healthcare System who underwent GI endoscopic evaluation for the sole indication of anemia and ferritin in the low normal range (40-100 ng/ml) were included in this study. MEASUREMENTS: Incidence of pathology of the upper and lower GI tract was determined. RESULTS: We identified 54 male patients who had a ferritin level of 40-100 ng/ml and no GI symptoms or known GI bleeding. Upper GI findings (malignancy, peptic ulcers, Helicobacter pylori gastritis, arteriovenous malformations) were found in 14/47 cases (30%). Lower gastrointestinal findings, including large tubular adenomas and arteriovenous malformation, were identified in 3/53 cases (6.7%). CONCLUSION: Our study supports GI endoscopy in anemic patients with ferritin between 40 and 100 ng/ml, even in the absence of GI symptoms or documented bleeding. SN - 0361-8609 UR - https://www.unboundmedicine.com/medline/citation/16628728/Gastrointestinal_endoscopic_findings_in_men_with_unexplained_anemia_and_low_normal_ferritin_values_ L2 - https://doi.org/10.1002/ajh.20613 DB - PRIME DP - Unbound Medicine ER -