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Orthostatic heart rate variability analysis in idiopathic Parkinson's disease.
Acta Neurol Scand. 2006 May; 113(5):288-93.AN

Abstract

OBJECTIVES

We evaluated time and spectral analyses of 24-h heart rate variability (HRV) and the heart rate responses to passive tilt in patients with idiopathic Parkinson's disease (IPD) in order to investigate cardiovascular autonomic functions.

MATERIAL AND METHODS

Twenty-three subjects with IPD without autonomic symptoms and 15 age-matched healthy controls were enrolled. Frequency- and time-domain HRV parameters were studied during resting and passive head-up tilt (HUT) test.

RESULTS

All time-domain parameters were found to be low in patients with IPD. In patients with IPD, both low frequency (LF) and high frequency (HF) decreased during HUT period and no significant change in LF to HF ratio was noted. Both time- and frequency-domain HRV indices showed no correlation with age, disease severity and duration, and with l-dopa medication.

CONCLUSION

The results indicate that impairment of autonomic nervous system function in IPD without autonomic symptoms is frequent, and does not show clear association with clinical stage and the age of the patients.

Authors+Show Affiliations

Department of Neurology, Akdeniz University School of Medicine, Antalya, Turkey. ebrumihci@akdeniz.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16629763

Citation

Mihci, E, et al. "Orthostatic Heart Rate Variability Analysis in Idiopathic Parkinson's Disease." Acta Neurologica Scandinavica, vol. 113, no. 5, 2006, pp. 288-93.
Mihci E, Kardelen F, Dora B, et al. Orthostatic heart rate variability analysis in idiopathic Parkinson's disease. Acta Neurol Scand. 2006;113(5):288-93.
Mihci, E., Kardelen, F., Dora, B., & Balkan, S. (2006). Orthostatic heart rate variability analysis in idiopathic Parkinson's disease. Acta Neurologica Scandinavica, 113(5), 288-93.
Mihci E, et al. Orthostatic Heart Rate Variability Analysis in Idiopathic Parkinson's Disease. Acta Neurol Scand. 2006;113(5):288-93. PubMed PMID: 16629763.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Orthostatic heart rate variability analysis in idiopathic Parkinson's disease. AU - Mihci,E, AU - Kardelen,F, AU - Dora,B, AU - Balkan,S, PY - 2006/4/25/pubmed PY - 2006/6/29/medline PY - 2006/4/25/entrez SP - 288 EP - 93 JF - Acta neurologica Scandinavica JO - Acta Neurol Scand VL - 113 IS - 5 N2 - OBJECTIVES: We evaluated time and spectral analyses of 24-h heart rate variability (HRV) and the heart rate responses to passive tilt in patients with idiopathic Parkinson's disease (IPD) in order to investigate cardiovascular autonomic functions. MATERIAL AND METHODS: Twenty-three subjects with IPD without autonomic symptoms and 15 age-matched healthy controls were enrolled. Frequency- and time-domain HRV parameters were studied during resting and passive head-up tilt (HUT) test. RESULTS: All time-domain parameters were found to be low in patients with IPD. In patients with IPD, both low frequency (LF) and high frequency (HF) decreased during HUT period and no significant change in LF to HF ratio was noted. Both time- and frequency-domain HRV indices showed no correlation with age, disease severity and duration, and with l-dopa medication. CONCLUSION: The results indicate that impairment of autonomic nervous system function in IPD without autonomic symptoms is frequent, and does not show clear association with clinical stage and the age of the patients. SN - 0001-6314 UR - https://www.unboundmedicine.com/medline/citation/16629763/Orthostatic_heart_rate_variability_analysis_in_idiopathic_Parkinson's_disease_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0001-6314&date=2006&volume=113&issue=5&spage=288 DB - PRIME DP - Unbound Medicine ER -