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Nonlinear relations between house dust mite allergen levels and mite sensitization in farm and nonfarm children.
Allergy. 2006 May; 61(5):640-7.A

Abstract

BACKGROUND

Low sensitization rates to common allergens have been observed in farm children, which might be due to high exposure to microbial agents. It is not known how microbial agents modify the association between specific allergen exposure and sensitization.

OBJECTIVE

To examine the relations between house dust mite allergen exposure and mite sensitization in farm and nonfarm children and to assess the effects of microbial agents levels on this association.

METHODS

Major mite allergens of Dermatophagoides pteronyssinus (Der p 1) and Dermatophagoides farinae (Der f 1), endotoxin, beta(1,3)-glucans and fungal extracellular polysaccharides were measured in mattress dust of 402 children participating in a cross-sectional study in five European countries. Mite allergen (Der p 1 + Der f 1) levels were divided into tertiles with cut-offs 1.4 and 10.4 microg/g. Sensitization was assessed by measurement of allergen-specific immunoglobulin E against house dust mite.

RESULTS

Prevalence ratios of mite sensitization for medium and high when compared with low mite allergen levels were 3.1 [1.7-5.7] and 1.4 [0.7-2.8] respectively. Highest mite sensitization rates at intermediate exposure levels were consistently observed across country (except for Sweden) and in both farm and nonfarm children. The shape of the dose-response curve was similar for above and below median mattress microbial agent levels, but the 'sensitization peak' appeared to be lower for above median levels.

CONCLUSIONS

Our data suggest a bell-shaped dose-response relationship between mite allergen exposure and sensitization to mite allergens. In populations with high microbial agent levels and low sensitization rates, the curve is shifted down.

Authors+Show Affiliations

Institute for Risk Assessment Sciences, University of Utrecht, Utrecht, the Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16629797

Citation

Schram-Bijkerk, D, et al. "Nonlinear Relations Between House Dust Mite Allergen Levels and Mite Sensitization in Farm and Nonfarm Children." Allergy, vol. 61, no. 5, 2006, pp. 640-7.
Schram-Bijkerk D, Doekes G, Boeve M, et al. Nonlinear relations between house dust mite allergen levels and mite sensitization in farm and nonfarm children. Allergy. 2006;61(5):640-7.
Schram-Bijkerk, D., Doekes, G., Boeve, M., Douwes, J., Riedler, J., Ublagger, E., von Mutius, E., Budde, J., Pershagen, G., van Hage, M., Wickman, M., Braun-Fahrländer, C., Waser, M., & Brunekreef, B. (2006). Nonlinear relations between house dust mite allergen levels and mite sensitization in farm and nonfarm children. Allergy, 61(5), 640-7.
Schram-Bijkerk D, et al. Nonlinear Relations Between House Dust Mite Allergen Levels and Mite Sensitization in Farm and Nonfarm Children. Allergy. 2006;61(5):640-7. PubMed PMID: 16629797.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nonlinear relations between house dust mite allergen levels and mite sensitization in farm and nonfarm children. AU - Schram-Bijkerk,D, AU - Doekes,G, AU - Boeve,M, AU - Douwes,J, AU - Riedler,J, AU - Ublagger,E, AU - von Mutius,E, AU - Budde,J, AU - Pershagen,G, AU - van Hage,M, AU - Wickman,M, AU - Braun-Fahrländer,C, AU - Waser,M, AU - Brunekreef,B, AU - ,, PY - 2006/4/25/pubmed PY - 2006/10/13/medline PY - 2006/4/25/entrez SP - 640 EP - 7 JF - Allergy JO - Allergy VL - 61 IS - 5 N2 - BACKGROUND: Low sensitization rates to common allergens have been observed in farm children, which might be due to high exposure to microbial agents. It is not known how microbial agents modify the association between specific allergen exposure and sensitization. OBJECTIVE: To examine the relations between house dust mite allergen exposure and mite sensitization in farm and nonfarm children and to assess the effects of microbial agents levels on this association. METHODS: Major mite allergens of Dermatophagoides pteronyssinus (Der p 1) and Dermatophagoides farinae (Der f 1), endotoxin, beta(1,3)-glucans and fungal extracellular polysaccharides were measured in mattress dust of 402 children participating in a cross-sectional study in five European countries. Mite allergen (Der p 1 + Der f 1) levels were divided into tertiles with cut-offs 1.4 and 10.4 microg/g. Sensitization was assessed by measurement of allergen-specific immunoglobulin E against house dust mite. RESULTS: Prevalence ratios of mite sensitization for medium and high when compared with low mite allergen levels were 3.1 [1.7-5.7] and 1.4 [0.7-2.8] respectively. Highest mite sensitization rates at intermediate exposure levels were consistently observed across country (except for Sweden) and in both farm and nonfarm children. The shape of the dose-response curve was similar for above and below median mattress microbial agent levels, but the 'sensitization peak' appeared to be lower for above median levels. CONCLUSIONS: Our data suggest a bell-shaped dose-response relationship between mite allergen exposure and sensitization to mite allergens. In populations with high microbial agent levels and low sensitization rates, the curve is shifted down. SN - 0105-4538 UR - https://www.unboundmedicine.com/medline/citation/16629797/Nonlinear_relations_between_house_dust_mite_allergen_levels_and_mite_sensitization_in_farm_and_nonfarm_children_ L2 - https://doi.org/10.1111/j.1398-9995.2006.01079.x DB - PRIME DP - Unbound Medicine ER -