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Prevalence of factor V Leiden and prothrombin G20210A mutations in Chinese patients with deep venous thrombosis and pulmonary embolism.
Clin Lab Haematol. 2006 Apr; 28(2):111-6.CL

Abstract

Venous thromboembolism (VTE) is a common vascular disease that results in two major clinical manifestations: deep venous thrombosis (DVT) and pulmonary embolism (PE). Several genetic risk factors, especially factor V Leiden and prothrombin G20210A mutations have been reported to be related to VTE in Caucasians, but the relationship remains controversial in other populations. Thus, the objective of the present study was to compare the frequency of the two mutations and also to investigate whether acquired risk factors other than genetic mutations may play a different role in Chinese VTE patients. Thirty-five patients were diagnosed with DVT concomitant PE, 178 patients with DVT, 54 patients with PE and 102 control subjects were recruited. The mutation was determined by the polymerase chain reaction-restriction fragment length polymorphism method. Of all subjects, none was a carrier of factor V Leiden or prothrombin G20210A mutations. The frequency of surgery was significantly higher in the PE group than that in other groups. There was no significant difference among the three groups in other known risk factors. The data presented here indicate that factor V Leiden and prothrombin G20210A mutations are very rare in the Chinese population, and the genetic risk profile of VTE in the Chinese population is different from that in Caucasians.

Authors+Show Affiliations

China-Japan Union Hospital, Ji Lin University, Changchun, China. zhaojj1@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16630215

Citation

Jun, Z J., et al. "Prevalence of Factor V Leiden and Prothrombin G20210A Mutations in Chinese Patients With Deep Venous Thrombosis and Pulmonary Embolism." Clinical and Laboratory Haematology, vol. 28, no. 2, 2006, pp. 111-6.
Jun ZJ, Ping T, Lei Y, et al. Prevalence of factor V Leiden and prothrombin G20210A mutations in Chinese patients with deep venous thrombosis and pulmonary embolism. Clin Lab Haematol. 2006;28(2):111-6.
Jun, Z. J., Ping, T., Lei, Y., Li, L., Ming, S. Y., & Jing, W. (2006). Prevalence of factor V Leiden and prothrombin G20210A mutations in Chinese patients with deep venous thrombosis and pulmonary embolism. Clinical and Laboratory Haematology, 28(2), 111-6.
Jun ZJ, et al. Prevalence of Factor V Leiden and Prothrombin G20210A Mutations in Chinese Patients With Deep Venous Thrombosis and Pulmonary Embolism. Clin Lab Haematol. 2006;28(2):111-6. PubMed PMID: 16630215.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of factor V Leiden and prothrombin G20210A mutations in Chinese patients with deep venous thrombosis and pulmonary embolism. AU - Jun,Z J, AU - Ping,T, AU - Lei,Y, AU - Li,L, AU - Ming,S Y, AU - Jing,W, PY - 2006/4/25/pubmed PY - 2006/8/30/medline PY - 2006/4/25/entrez SP - 111 EP - 6 JF - Clinical and laboratory haematology JO - Clin Lab Haematol VL - 28 IS - 2 N2 - Venous thromboembolism (VTE) is a common vascular disease that results in two major clinical manifestations: deep venous thrombosis (DVT) and pulmonary embolism (PE). Several genetic risk factors, especially factor V Leiden and prothrombin G20210A mutations have been reported to be related to VTE in Caucasians, but the relationship remains controversial in other populations. Thus, the objective of the present study was to compare the frequency of the two mutations and also to investigate whether acquired risk factors other than genetic mutations may play a different role in Chinese VTE patients. Thirty-five patients were diagnosed with DVT concomitant PE, 178 patients with DVT, 54 patients with PE and 102 control subjects were recruited. The mutation was determined by the polymerase chain reaction-restriction fragment length polymorphism method. Of all subjects, none was a carrier of factor V Leiden or prothrombin G20210A mutations. The frequency of surgery was significantly higher in the PE group than that in other groups. There was no significant difference among the three groups in other known risk factors. The data presented here indicate that factor V Leiden and prothrombin G20210A mutations are very rare in the Chinese population, and the genetic risk profile of VTE in the Chinese population is different from that in Caucasians. SN - 0141-9854 UR - https://www.unboundmedicine.com/medline/citation/16630215/Prevalence_of_factor_V_Leiden_and_prothrombin_G20210A_mutations_in_Chinese_patients_with_deep_venous_thrombosis_and_pulmonary_embolism_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0141-9854&date=2006&volume=28&issue=2&spage=111 DB - PRIME DP - Unbound Medicine ER -