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Association between nonsteroidal anti-inflammatory drugs and prostate cancer occurrence.
Cancer J. 2006 Mar-Apr; 12(2):130-5.CJ

Abstract

Prostate cancer is the most common malignancy among men in Western nations. Previous studies indicate that nonsteroidal anti-inflammatory drugs have an inhibitory effect on prostate cancer cells. We evaluated the association between frequent use of nonsteroidal anti-inflammatory drugs and prostate cancer occurrence.

METHODS

We conducted a nested case-control study using medical administrative databases. All men older than 65 years of age who had filled at least one prescription for nonselective nonsteroidal anti-inflammatory drugs, cyclooxygenase-2 inhibitors (coxibs), aspirin, or acetaminophen between January 1999 and December 2002 were eligible. Among this group, we identified men who underwent prostate biopsy between January 2000 and June 2002 and did not have a diagnosis of any cancer in the preceding 2-year period. Cases were those with a diagnosis of prostate cancer. Controls were those who did not receive a diagnosis of any cancer. Logistic regression models were used to determine associations between prostate cancer occurrence and frequent exposure (more than 4 months) to nonsteroidal anti-inflammatory drugs/cyclooxygenase-2 inhibitors or aspirin during the prior 2 years in comparison with no exposure to any of these drugs, adjusting for age and prior finasteride use.

RESULTS

We identified 2025 cases and 2150 controls. Older men were at greater risk for developing prostate cancer. Exposure to nonsteroidal anti-inflammatory drugs/cyclooxygenase-2 inhibitors was associated with a reduced likelihood of prostate cancer (odds ratio [OR], 0.71; 95% confidence interval [CI], 0.58-0.86) as was exposure to aspirin (OR, 0.84; 95% CI, 0.74-0.96).

DISCUSSION

Our results suggest that among men 65 years of age or older, frequent use of nonsteroidal anti-inflammatory drugs/cyclooxygenase-2 inhibitors and use of aspirin are associated with a reduced risk of prostate cancer.

Authors+Show Affiliations

Research Institute, Department of Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

16630404

Citation

Dasgupta, Kaberi, et al. "Association Between Nonsteroidal Anti-inflammatory Drugs and Prostate Cancer Occurrence." Cancer Journal (Sudbury, Mass.), vol. 12, no. 2, 2006, pp. 130-5.
Dasgupta K, Di Cesar D, Ghosn J, et al. Association between nonsteroidal anti-inflammatory drugs and prostate cancer occurrence. Cancer J. 2006;12(2):130-5.
Dasgupta, K., Di Cesar, D., Ghosn, J., Rajan, R., Mahmud, S., & Rahme, E. (2006). Association between nonsteroidal anti-inflammatory drugs and prostate cancer occurrence. Cancer Journal (Sudbury, Mass.), 12(2), 130-5.
Dasgupta K, et al. Association Between Nonsteroidal Anti-inflammatory Drugs and Prostate Cancer Occurrence. Cancer J. 2006;12(2):130-5. PubMed PMID: 16630404.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between nonsteroidal anti-inflammatory drugs and prostate cancer occurrence. AU - Dasgupta,Kaberi, AU - Di Cesar,David, AU - Ghosn,Joumana, AU - Rajan,Raghu, AU - Mahmud,Salaheddin, AU - Rahme,Elham, PY - 2006/4/25/pubmed PY - 2006/9/9/medline PY - 2006/4/25/entrez SP - 130 EP - 5 JF - Cancer journal (Sudbury, Mass.) JO - Cancer J VL - 12 IS - 2 N2 - UNLABELLED: Prostate cancer is the most common malignancy among men in Western nations. Previous studies indicate that nonsteroidal anti-inflammatory drugs have an inhibitory effect on prostate cancer cells. We evaluated the association between frequent use of nonsteroidal anti-inflammatory drugs and prostate cancer occurrence. METHODS: We conducted a nested case-control study using medical administrative databases. All men older than 65 years of age who had filled at least one prescription for nonselective nonsteroidal anti-inflammatory drugs, cyclooxygenase-2 inhibitors (coxibs), aspirin, or acetaminophen between January 1999 and December 2002 were eligible. Among this group, we identified men who underwent prostate biopsy between January 2000 and June 2002 and did not have a diagnosis of any cancer in the preceding 2-year period. Cases were those with a diagnosis of prostate cancer. Controls were those who did not receive a diagnosis of any cancer. Logistic regression models were used to determine associations between prostate cancer occurrence and frequent exposure (more than 4 months) to nonsteroidal anti-inflammatory drugs/cyclooxygenase-2 inhibitors or aspirin during the prior 2 years in comparison with no exposure to any of these drugs, adjusting for age and prior finasteride use. RESULTS: We identified 2025 cases and 2150 controls. Older men were at greater risk for developing prostate cancer. Exposure to nonsteroidal anti-inflammatory drugs/cyclooxygenase-2 inhibitors was associated with a reduced likelihood of prostate cancer (odds ratio [OR], 0.71; 95% confidence interval [CI], 0.58-0.86) as was exposure to aspirin (OR, 0.84; 95% CI, 0.74-0.96). DISCUSSION: Our results suggest that among men 65 years of age or older, frequent use of nonsteroidal anti-inflammatory drugs/cyclooxygenase-2 inhibitors and use of aspirin are associated with a reduced risk of prostate cancer. SN - 1528-9117 UR - https://www.unboundmedicine.com/medline/citation/16630404/Association_between_nonsteroidal_anti_inflammatory_drugs_and_prostate_cancer_occurrence_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=16630404.ui DB - PRIME DP - Unbound Medicine ER -