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[Diagnosis and differential diagnosis of intraductal papillary mucinous neoplasm of pancreas].
Zhonghua Bing Li Xue Za Zhi. 2006 Feb; 35(2):77-81.ZB

Abstract

OBJECTIVE

To study the clinicopathologic features of intraductal papillary mucinous neoplasm (IPMN) and its distinction from mucinous cystic neoplasm of pancreas.

METHODS

The clinical, radiologic and histologic features of 17 cases of IPMN and 13 cases of mucinous cystic neoplasm (MCN) were reviewed. Mucin profiles (MUC1, MUC2 and MUC5AC) were studied by histology (HE) and immunohistochemistry (EnVision).

RESULTS

10 of the 17 cases of IPMN were males. 13 cases of the IPMN were located in head of pancreas. Communication with the main pancreatic duct was demonstrated in 15 cases. Histologically, there were mild to severe papillary ingrowths of dysplastic epithelial cells, associated with intervening normal or atrophic pancreatic parenchyma. Ovarian-like stroma was not seen. Ancillary investigations showed that MUC2 and MUC5AC were detected in tumor cells of 9 and 4 cases respectively. The 4 cases with invasive component showed MUC1 positivity. On the other hand, 11 of the 13 cases of MCN occurred in middle-aged to elderly females and were located in the body and tail of pancreas. Ovarian-like stroma was commonly seen and there was no connection with the main pancreatic duct. All non-invasive MCN, regardless of the degree of cytologic atypia, were positive for MUC5AC (but not MUC2). In the 2 cases with invasive component, MUC1 expression was observed, as in IPMN.

CONCLUSIONS

The age and sex of patients, tumor location, absence of ovarian-like stroma, communication with main pancreatic duct and characteristic mucin profiles represent useful parameters in distinguishing IPMN from MCN of pancreas. The tumor cells of IPMN express mainly MUC2, while those of MCN express MUC5AC. MUC1 may also be a useful marker in demonstration of stromal invasion in these tumors.

Authors+Show Affiliations

Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, China. yji@zshospital.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

16630480

Citation

Ji, Yuan, et al. "[Diagnosis and Differential Diagnosis of Intraductal Papillary Mucinous Neoplasm of Pancreas]." Zhonghua Bing Li Xue Za Zhi = Chinese Journal of Pathology, vol. 35, no. 2, 2006, pp. 77-81.
Ji Y, Tan YS, Zhu XZ, et al. [Diagnosis and differential diagnosis of intraductal papillary mucinous neoplasm of pancreas]. Zhonghua Bing Li Xue Za Zhi. 2006;35(2):77-81.
Ji, Y., Tan, Y. S., Zhu, X. Z., Zeng, H. Y., Kuang, T. T., & Jin, D. Y. (2006). [Diagnosis and differential diagnosis of intraductal papillary mucinous neoplasm of pancreas]. Zhonghua Bing Li Xue Za Zhi = Chinese Journal of Pathology, 35(2), 77-81.
Ji Y, et al. [Diagnosis and Differential Diagnosis of Intraductal Papillary Mucinous Neoplasm of Pancreas]. Zhonghua Bing Li Xue Za Zhi. 2006;35(2):77-81. PubMed PMID: 16630480.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Diagnosis and differential diagnosis of intraductal papillary mucinous neoplasm of pancreas]. AU - Ji,Yuan, AU - Tan,Yun-shan, AU - Zhu,Xiong-zeng, AU - Zeng,Hai-ying, AU - Kuang,Tian-tao, AU - Jin,Da-yong, PY - 2006/4/25/pubmed PY - 2006/12/15/medline PY - 2006/4/25/entrez SP - 77 EP - 81 JF - Zhonghua bing li xue za zhi = Chinese journal of pathology JO - Zhonghua Bing Li Xue Za Zhi VL - 35 IS - 2 N2 - OBJECTIVE: To study the clinicopathologic features of intraductal papillary mucinous neoplasm (IPMN) and its distinction from mucinous cystic neoplasm of pancreas. METHODS: The clinical, radiologic and histologic features of 17 cases of IPMN and 13 cases of mucinous cystic neoplasm (MCN) were reviewed. Mucin profiles (MUC1, MUC2 and MUC5AC) were studied by histology (HE) and immunohistochemistry (EnVision). RESULTS: 10 of the 17 cases of IPMN were males. 13 cases of the IPMN were located in head of pancreas. Communication with the main pancreatic duct was demonstrated in 15 cases. Histologically, there were mild to severe papillary ingrowths of dysplastic epithelial cells, associated with intervening normal or atrophic pancreatic parenchyma. Ovarian-like stroma was not seen. Ancillary investigations showed that MUC2 and MUC5AC were detected in tumor cells of 9 and 4 cases respectively. The 4 cases with invasive component showed MUC1 positivity. On the other hand, 11 of the 13 cases of MCN occurred in middle-aged to elderly females and were located in the body and tail of pancreas. Ovarian-like stroma was commonly seen and there was no connection with the main pancreatic duct. All non-invasive MCN, regardless of the degree of cytologic atypia, were positive for MUC5AC (but not MUC2). In the 2 cases with invasive component, MUC1 expression was observed, as in IPMN. CONCLUSIONS: The age and sex of patients, tumor location, absence of ovarian-like stroma, communication with main pancreatic duct and characteristic mucin profiles represent useful parameters in distinguishing IPMN from MCN of pancreas. The tumor cells of IPMN express mainly MUC2, while those of MCN express MUC5AC. MUC1 may also be a useful marker in demonstration of stromal invasion in these tumors. SN - 0529-5807 UR - https://www.unboundmedicine.com/medline/citation/16630480/[Diagnosis_and_differential_diagnosis_of_intraductal_papillary_mucinous_neoplasm_of_pancreas]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=0529-5807&year=2006&vol=35&issue=2&fpage=77 DB - PRIME DP - Unbound Medicine ER -