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Functional correlates of verbal memory deficits emerging during nicotine withdrawal in abstinent adolescent cannabis users.
Biol Psychiatry. 2007 Jan 01; 61(1):31-40.BP

Abstract

BACKGROUND

Cannabis remains the most widely used illicit substance by adolescents and is typically consumed by this population in the context of ongoing tobacco use. Human studies have shown that both cannabis and tobacco exert effects on cognitive function; however, little is known about possible interacting effects of these drugs on brain function and cognition during adolescent development.

METHODS

Verbal learning and memory were assessed in 20 adolescent users of tobacco and cannabis and 25 adolescent tobacco users with minimal history of cannabis use. Functional magnetic resonance imaging was used to examine brain function and functional connectivity while a subset of these subjects performed a verbal working memory task.

RESULTS

Delayed recall of verbal stimuli deteriorated during nicotine withdrawal among cannabis users but not among comparison subjects. During high verbal working memory load, nicotine withdrawal selectively increased task-related activation of posterior cortical regions and was associated with disruption of frontoparietal connectivity in adolescent cannabis users relative to comparison subjects.

CONCLUSIONS

These observations suggest that cannabis use during adolescent development may disrupt neurocircuitry supporting verbal memory formation and that deficits associated with disruption of these neurocircuits are unmasked during nicotine withdrawal.

Authors+Show Affiliations

Department of Psychiatry, Yale University School of Medicine, Connecticut 06519, USA. leslie.jacobsen@yale.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16631130

Citation

Jacobsen, Leslie K., et al. "Functional Correlates of Verbal Memory Deficits Emerging During Nicotine Withdrawal in Abstinent Adolescent Cannabis Users." Biological Psychiatry, vol. 61, no. 1, 2007, pp. 31-40.
Jacobsen LK, Pugh KR, Constable RT, et al. Functional correlates of verbal memory deficits emerging during nicotine withdrawal in abstinent adolescent cannabis users. Biol Psychiatry. 2007;61(1):31-40.
Jacobsen, L. K., Pugh, K. R., Constable, R. T., Westerveld, M., & Mencl, W. E. (2007). Functional correlates of verbal memory deficits emerging during nicotine withdrawal in abstinent adolescent cannabis users. Biological Psychiatry, 61(1), 31-40.
Jacobsen LK, et al. Functional Correlates of Verbal Memory Deficits Emerging During Nicotine Withdrawal in Abstinent Adolescent Cannabis Users. Biol Psychiatry. 2007 Jan 1;61(1):31-40. PubMed PMID: 16631130.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Functional correlates of verbal memory deficits emerging during nicotine withdrawal in abstinent adolescent cannabis users. AU - Jacobsen,Leslie K, AU - Pugh,Kenneth R, AU - Constable,Robert T, AU - Westerveld,Michael, AU - Mencl,W Einar, Y1 - 2006/04/21/ PY - 2005/04/27/received PY - 2005/12/07/revised PY - 2006/02/22/accepted PY - 2006/4/25/pubmed PY - 2007/2/21/medline PY - 2006/4/25/entrez SP - 31 EP - 40 JF - Biological psychiatry JO - Biol. Psychiatry VL - 61 IS - 1 N2 - BACKGROUND: Cannabis remains the most widely used illicit substance by adolescents and is typically consumed by this population in the context of ongoing tobacco use. Human studies have shown that both cannabis and tobacco exert effects on cognitive function; however, little is known about possible interacting effects of these drugs on brain function and cognition during adolescent development. METHODS: Verbal learning and memory were assessed in 20 adolescent users of tobacco and cannabis and 25 adolescent tobacco users with minimal history of cannabis use. Functional magnetic resonance imaging was used to examine brain function and functional connectivity while a subset of these subjects performed a verbal working memory task. RESULTS: Delayed recall of verbal stimuli deteriorated during nicotine withdrawal among cannabis users but not among comparison subjects. During high verbal working memory load, nicotine withdrawal selectively increased task-related activation of posterior cortical regions and was associated with disruption of frontoparietal connectivity in adolescent cannabis users relative to comparison subjects. CONCLUSIONS: These observations suggest that cannabis use during adolescent development may disrupt neurocircuitry supporting verbal memory formation and that deficits associated with disruption of these neurocircuits are unmasked during nicotine withdrawal. SN - 0006-3223 UR - https://www.unboundmedicine.com/medline/citation/16631130/Functional_correlates_of_verbal_memory_deficits_emerging_during_nicotine_withdrawal_in_abstinent_adolescent_cannabis_users_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-3223(06)00232-0 DB - PRIME DP - Unbound Medicine ER -