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Involvement of histamine receptors in the acquisition of inhibitory avoidance in Carassius auratus.
Prog Neuropsychopharmacol Biol Psychiatry. 2006 Sep 30; 30(7):1246-50.PN

Abstract

This study investigated the involvement of H(1) and H(2) histaminegic receptors on the acquisition of a new task in Carassius auratus by using an inhibitory avoidance paradigm in which the animals had to learn to avoid an aversive stimulus. Before training, the fish received injections of H(2) antagonist zolantidine at a dose of 20 mg/kg, or H(1) antagonist chlorpheniramine at a dose of 4 or 16 mg/kg. Control animals were injected with distilled water. A facilitatory effect of chlorpheniramine was observed at the dose of 16 mg/kg. On the other hand, the administration of 20 mg/kg of zolantidine inhibited acquisition. Place preference conditioning was used to observe the aversive or reinforcing effects of the drugs, which could interfere with the inhibitory avoidance procedure; however, no effects were observed. Thus, it can be suggested that both receptors, H(1) and H(2), are involved in the acquisition of a new task in this species.

Authors+Show Affiliations

Laboratory of Neuroscience, Universidade Federal de São Carlos, São Carlos, SP-Brazil.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16631292

Citation

Cofiel, Luciana Pereira do Vale, and Rosana Mattioli. "Involvement of Histamine Receptors in the Acquisition of Inhibitory Avoidance in Carassius Auratus." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 30, no. 7, 2006, pp. 1246-50.
Cofiel LP, Mattioli R. Involvement of histamine receptors in the acquisition of inhibitory avoidance in Carassius auratus. Prog Neuropsychopharmacol Biol Psychiatry. 2006;30(7):1246-50.
Cofiel, L. P., & Mattioli, R. (2006). Involvement of histamine receptors in the acquisition of inhibitory avoidance in Carassius auratus. Progress in Neuro-psychopharmacology & Biological Psychiatry, 30(7), 1246-50.
Cofiel LP, Mattioli R. Involvement of Histamine Receptors in the Acquisition of Inhibitory Avoidance in Carassius Auratus. Prog Neuropsychopharmacol Biol Psychiatry. 2006 Sep 30;30(7):1246-50. PubMed PMID: 16631292.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Involvement of histamine receptors in the acquisition of inhibitory avoidance in Carassius auratus. AU - Cofiel,Luciana Pereira do Vale, AU - Mattioli,Rosana, Y1 - 2006/04/24/ PY - 2006/4/25/pubmed PY - 2006/11/1/medline PY - 2006/4/25/entrez SP - 1246 EP - 50 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog Neuropsychopharmacol Biol Psychiatry VL - 30 IS - 7 N2 - This study investigated the involvement of H(1) and H(2) histaminegic receptors on the acquisition of a new task in Carassius auratus by using an inhibitory avoidance paradigm in which the animals had to learn to avoid an aversive stimulus. Before training, the fish received injections of H(2) antagonist zolantidine at a dose of 20 mg/kg, or H(1) antagonist chlorpheniramine at a dose of 4 or 16 mg/kg. Control animals were injected with distilled water. A facilitatory effect of chlorpheniramine was observed at the dose of 16 mg/kg. On the other hand, the administration of 20 mg/kg of zolantidine inhibited acquisition. Place preference conditioning was used to observe the aversive or reinforcing effects of the drugs, which could interfere with the inhibitory avoidance procedure; however, no effects were observed. Thus, it can be suggested that both receptors, H(1) and H(2), are involved in the acquisition of a new task in this species. SN - 0278-5846 UR - https://www.unboundmedicine.com/medline/citation/16631292/Involvement_of_histamine_receptors_in_the_acquisition_of_inhibitory_avoidance_in_Carassius_auratus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(06)00100-X DB - PRIME DP - Unbound Medicine ER -