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In vivo neuropathology of the hippocampal formation in AD: a radial mapping MR-based study.

Abstract

Early involvement of the hippocampal formation is the biological basis of the typical learning deficit in Alzheimer's disease (AD). However, the hippocampal formation is unevenly affected by AD pathology, deposits of plaques and tangles being particularly dense in the CA1 field and subiculum. The aim of the study was to locate in vivo the structural changes within the hippocampal formation in AD patients of mild to moderate severity. A group of 28 AD patients and 40 cognitively intact persons (age 74 +/- 9 and 71 +/- 7 years) underwent T1-weighted high-resolution MR scans. The hippocampal formation was isolated by manually tracing on 35 coronal slices the outlines of the hippocampus proper and subiculum after registration to a common stereotactic space. Group differences were assessed with algorithms developed ad hoc that make use of three-dimensional parametric surface mesh models. In AD patients, significant atrophic changes amounting to tissue loss of 20% or more were found in regions of the hippocampal formation corresponding to the CA1 field and part of the subiculum. Regions corresponding to the CA2-3 fields were remarkably spared. We conclude that the regions of the hippocampal formation that we found atrophic in AD patients are those known to be affected from pathological studies. This study supports the possibility of carrying out in vivo macroscopic neuropathology of the hippocampus with MR imaging in the neurodegenerative dementias.

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  • Authors+Show Affiliations

    ,

    LENITEM Laboratory of Epidemiology Neuroimaging and Telemedicine, IRCCS Centro S. Giovanni di Dio-FBF, via Pilastroni 4, 25125 Brescia, Italy. gfrisoni@fatebenefratelli.it

    , , , ,

    Source

    NeuroImage 32:1 2006 Aug 01 pg 104-10

    MeSH

    Age of Onset
    Aged
    Aged, 80 and over
    Alzheimer Disease
    Brain Mapping
    Female
    Hippocampus
    Humans
    Image Processing, Computer-Assisted
    Magnetic Resonance Imaging
    Male
    Middle Aged
    Neurofibrillary Tangles
    Plaque, Amyloid
    Reference Values
    Sensitivity and Specificity

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    16631382

    Citation

    Frisoni, G B., et al. "In Vivo Neuropathology of the Hippocampal Formation in AD: a Radial Mapping MR-based Study." NeuroImage, vol. 32, no. 1, 2006, pp. 104-10.
    Frisoni GB, Sabattoli F, Lee AD, et al. In vivo neuropathology of the hippocampal formation in AD: a radial mapping MR-based study. Neuroimage. 2006;32(1):104-10.
    Frisoni, G. B., Sabattoli, F., Lee, A. D., Dutton, R. A., Toga, A. W., & Thompson, P. M. (2006). In vivo neuropathology of the hippocampal formation in AD: a radial mapping MR-based study. NeuroImage, 32(1), pp. 104-10.
    Frisoni GB, et al. In Vivo Neuropathology of the Hippocampal Formation in AD: a Radial Mapping MR-based Study. Neuroimage. 2006 Aug 1;32(1):104-10. PubMed PMID: 16631382.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - In vivo neuropathology of the hippocampal formation in AD: a radial mapping MR-based study. AU - Frisoni,G B, AU - Sabattoli,F, AU - Lee,A D, AU - Dutton,R A, AU - Toga,A W, AU - Thompson,P M, Y1 - 2006/05/02/ PY - 2005/09/17/received PY - 2006/03/02/revised PY - 2006/03/07/accepted PY - 2006/4/25/pubmed PY - 2006/9/16/medline PY - 2006/4/25/entrez SP - 104 EP - 10 JF - NeuroImage JO - Neuroimage VL - 32 IS - 1 N2 - Early involvement of the hippocampal formation is the biological basis of the typical learning deficit in Alzheimer's disease (AD). However, the hippocampal formation is unevenly affected by AD pathology, deposits of plaques and tangles being particularly dense in the CA1 field and subiculum. The aim of the study was to locate in vivo the structural changes within the hippocampal formation in AD patients of mild to moderate severity. A group of 28 AD patients and 40 cognitively intact persons (age 74 +/- 9 and 71 +/- 7 years) underwent T1-weighted high-resolution MR scans. The hippocampal formation was isolated by manually tracing on 35 coronal slices the outlines of the hippocampus proper and subiculum after registration to a common stereotactic space. Group differences were assessed with algorithms developed ad hoc that make use of three-dimensional parametric surface mesh models. In AD patients, significant atrophic changes amounting to tissue loss of 20% or more were found in regions of the hippocampal formation corresponding to the CA1 field and part of the subiculum. Regions corresponding to the CA2-3 fields were remarkably spared. We conclude that the regions of the hippocampal formation that we found atrophic in AD patients are those known to be affected from pathological studies. This study supports the possibility of carrying out in vivo macroscopic neuropathology of the hippocampus with MR imaging in the neurodegenerative dementias. SN - 1053-8119 UR - https://www.unboundmedicine.com/medline/citation/16631382/In_vivo_neuropathology_of_the_hippocampal_formation_in_AD:_a_radial_mapping_MR_based_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1053-8119(06)00181-9 DB - PRIME DP - Unbound Medicine ER -