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Maternal folic acid supplementation to dams on marginal protein level alters brain fatty acid levels of their adult offspring.

Abstract

Studies on fetal programming of adult diseases have highlighted the importance of maternal nutrition during pregnancy. Folic acid and long-chain essential polyunsaturated fatty acids (LC-PUFAs) have independent effects on fetal growth. However, folic acid effects may also involve alteration of LC-PUFA metabolism. Because marginal deficiency of LC-PUFAs during critical periods of brain growth and development is associated with risks for adult diseases, it is highly relevant to investigate how maternal supplementation of such nutrients can alter brain fatty acid levels. We examined the impact of folic acid supplementation, conventionally used in maternal intervention, on brain essential fatty acid levels and plasma corticosterone concentrations in adult offspring at 11 months of age. Pregnant female rats from 4 groups (6 in each) were fed with casein diets either with 18 g protein/100 g diet (control diet) or treatment diets that were marginal in protein (MP), such as 12 g protein/100 g diet supplemented with 8 mg folic acid (FAS/MP), 12 g protein/100 g diet without folic acid (FAD/MP), or 12 g protein/100 g diet (MP) with 2 mg folic acid. Pups were weaned to a standard laboratory diet with 18 g protein/100 g diet. All male adult offspring in the FAS/MP group showed lower docosahexaenoic acid (P<.05) as compared with control adult offspring (6.04+/-2.28 vs 10.33+/-0.86 g/100 g fatty acids) and higher n-6/n-3 ratio (P<.05). Docosahexaenoic acid levels in FAS/MP adult offspring were also lower (P<.05) when compared with the MP group. Plasma corticosterone concentrations were higher (P<.05) in male adult offspring from the FAS/MP group compared with control as well as the MP adult offspring. Results suggest that maternal folic acid supplementation at MP intake decreased brain docosahexaenoic acid levels probably involving corticosterone increase.

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  • Authors+Show Affiliations

    ,

    Biometry and Nutrition Unit, Agharkar Research Institute, Pune 411004, India. raoari@yahoo.com

    , , ,

    Source

    MeSH

    Animals
    Body Weight
    Brain
    Corticosterone
    Dietary Proteins
    Dietary Supplements
    Eating
    Fatty Acids
    Fatty Acids, Omega-3
    Fatty Acids, Omega-6
    Female
    Fetal Development
    Folic Acid
    Liver
    Male
    Organ Size
    Pregnancy
    Prenatal Exposure Delayed Effects
    Protein Deficiency
    Random Allocation
    Rats
    Rats, Wistar

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16631439

    Citation

    Rao, Shobha, et al. "Maternal Folic Acid Supplementation to Dams On Marginal Protein Level Alters Brain Fatty Acid Levels of Their Adult Offspring." Metabolism: Clinical and Experimental, vol. 55, no. 5, 2006, pp. 628-34.
    Rao S, Joshi S, Kale A, et al. Maternal folic acid supplementation to dams on marginal protein level alters brain fatty acid levels of their adult offspring. Metab Clin Exp. 2006;55(5):628-34.
    Rao, S., Joshi, S., Kale, A., Hegde, M., & Mahadik, S. (2006). Maternal folic acid supplementation to dams on marginal protein level alters brain fatty acid levels of their adult offspring. Metabolism: Clinical and Experimental, 55(5), pp. 628-34.
    Rao S, et al. Maternal Folic Acid Supplementation to Dams On Marginal Protein Level Alters Brain Fatty Acid Levels of Their Adult Offspring. Metab Clin Exp. 2006;55(5):628-34. PubMed PMID: 16631439.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Maternal folic acid supplementation to dams on marginal protein level alters brain fatty acid levels of their adult offspring. AU - Rao,Shobha, AU - Joshi,Sadhana, AU - Kale,Anvita, AU - Hegde,Mahabaleshwar, AU - Mahadik,Sahebarao, PY - 2005/03/14/received PY - 2005/12/08/accepted PY - 2006/4/25/pubmed PY - 2006/6/2/medline PY - 2006/4/25/entrez SP - 628 EP - 34 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 55 IS - 5 N2 - Studies on fetal programming of adult diseases have highlighted the importance of maternal nutrition during pregnancy. Folic acid and long-chain essential polyunsaturated fatty acids (LC-PUFAs) have independent effects on fetal growth. However, folic acid effects may also involve alteration of LC-PUFA metabolism. Because marginal deficiency of LC-PUFAs during critical periods of brain growth and development is associated with risks for adult diseases, it is highly relevant to investigate how maternal supplementation of such nutrients can alter brain fatty acid levels. We examined the impact of folic acid supplementation, conventionally used in maternal intervention, on brain essential fatty acid levels and plasma corticosterone concentrations in adult offspring at 11 months of age. Pregnant female rats from 4 groups (6 in each) were fed with casein diets either with 18 g protein/100 g diet (control diet) or treatment diets that were marginal in protein (MP), such as 12 g protein/100 g diet supplemented with 8 mg folic acid (FAS/MP), 12 g protein/100 g diet without folic acid (FAD/MP), or 12 g protein/100 g diet (MP) with 2 mg folic acid. Pups were weaned to a standard laboratory diet with 18 g protein/100 g diet. All male adult offspring in the FAS/MP group showed lower docosahexaenoic acid (P<.05) as compared with control adult offspring (6.04+/-2.28 vs 10.33+/-0.86 g/100 g fatty acids) and higher n-6/n-3 ratio (P<.05). Docosahexaenoic acid levels in FAS/MP adult offspring were also lower (P<.05) when compared with the MP group. Plasma corticosterone concentrations were higher (P<.05) in male adult offspring from the FAS/MP group compared with control as well as the MP adult offspring. Results suggest that maternal folic acid supplementation at MP intake decreased brain docosahexaenoic acid levels probably involving corticosterone increase. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/16631439/Maternal_folic_acid_supplementation_to_dams_on_marginal_protein_level_alters_brain_fatty_acid_levels_of_their_adult_offspring_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(06)00009-6 DB - PRIME DP - Unbound Medicine ER -