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Is visceral adipose tissue a determinant of von Willebrand factor in overweight and obese premenopausal women?
Metabolism 2006; 55(5):650-5M

Abstract

Visceral obesity has been associated with an increased cardiovascular risk. However, the exact mechanisms are not completely clear. In this study we investigated the relationship between von Willebrand factor (vWF) and visceral adipose tissue (VAT) in a group of 181 overweight and obese premenopausal women visiting the weight management clinic of a university hospital. von Willebrand factor antigen (vWF:Ag), plasminogen activator inhibitor 1 (PAI-1) activity, VAT (computed tomography scan), insulin resistance (homeostasis model assessment of insulin resistance), and other anthropometric and metabolic parameters were measured. Subjects with VAT in the highest quintile had significantly higher levels of vWF:Ag (171+/-60 vs 129+/-40%; P=.001) and PAI-1 (24.7+/-8.5 vs 15.2+/-12.0 AU/mL; P<.001) compared with subjects in the lowest quintile. After correction for fat mass and homeostasis model assessment of insulin resistance the difference was still significant for vWF:Ag (P=.046), but not for PAI-1 (P>.05). Stepwise multiple regression analysis showed VAT and insulin resistance as independent determinants of vWF:Ag, whereas waist circumference, high-density lipoprotein cholesterol, and insulin resistance were independent determinants of PAI-1 activity. In a subgroup of 115 patients, we measured high-sensitivity C-reactive protein and found it to influence the relationship between VAT and vWF:Ag (r=0.16; P=.088), whereas the relationship with PAI-1 was still significant (r=0.21; P=.025). The results from this preliminary study suggest a plausible relation between visceral obesity and endothelial activation, possibly mediated by low-grade inflammation.

Authors+Show Affiliations

Department of Diabetology, Metabolism and Clinical Nutrition, Faculty of Medicine, University Hospital Antwerp, University of Antwerp (UA), B-2650 Edegem-Antwerp, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16631442

Citation

Mertens, Ilse, et al. "Is Visceral Adipose Tissue a Determinant of Von Willebrand Factor in Overweight and Obese Premenopausal Women?" Metabolism: Clinical and Experimental, vol. 55, no. 5, 2006, pp. 650-5.
Mertens I, Van der Planken M, Corthouts B, et al. Is visceral adipose tissue a determinant of von Willebrand factor in overweight and obese premenopausal women? Metab Clin Exp. 2006;55(5):650-5.
Mertens, I., Van der Planken, M., Corthouts, B., & Van Gaal, L. F. (2006). Is visceral adipose tissue a determinant of von Willebrand factor in overweight and obese premenopausal women? Metabolism: Clinical and Experimental, 55(5), pp. 650-5.
Mertens I, et al. Is Visceral Adipose Tissue a Determinant of Von Willebrand Factor in Overweight and Obese Premenopausal Women. Metab Clin Exp. 2006;55(5):650-5. PubMed PMID: 16631442.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is visceral adipose tissue a determinant of von Willebrand factor in overweight and obese premenopausal women? AU - Mertens,Ilse, AU - Van der Planken,Marc, AU - Corthouts,Bob, AU - Van Gaal,Luc F, PY - 2006/4/25/pubmed PY - 2006/6/2/medline PY - 2006/4/25/entrez SP - 650 EP - 5 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 55 IS - 5 N2 - Visceral obesity has been associated with an increased cardiovascular risk. However, the exact mechanisms are not completely clear. In this study we investigated the relationship between von Willebrand factor (vWF) and visceral adipose tissue (VAT) in a group of 181 overweight and obese premenopausal women visiting the weight management clinic of a university hospital. von Willebrand factor antigen (vWF:Ag), plasminogen activator inhibitor 1 (PAI-1) activity, VAT (computed tomography scan), insulin resistance (homeostasis model assessment of insulin resistance), and other anthropometric and metabolic parameters were measured. Subjects with VAT in the highest quintile had significantly higher levels of vWF:Ag (171+/-60 vs 129+/-40%; P=.001) and PAI-1 (24.7+/-8.5 vs 15.2+/-12.0 AU/mL; P<.001) compared with subjects in the lowest quintile. After correction for fat mass and homeostasis model assessment of insulin resistance the difference was still significant for vWF:Ag (P=.046), but not for PAI-1 (P>.05). Stepwise multiple regression analysis showed VAT and insulin resistance as independent determinants of vWF:Ag, whereas waist circumference, high-density lipoprotein cholesterol, and insulin resistance were independent determinants of PAI-1 activity. In a subgroup of 115 patients, we measured high-sensitivity C-reactive protein and found it to influence the relationship between VAT and vWF:Ag (r=0.16; P=.088), whereas the relationship with PAI-1 was still significant (r=0.21; P=.025). The results from this preliminary study suggest a plausible relation between visceral obesity and endothelial activation, possibly mediated by low-grade inflammation. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/16631442/Is_visceral_adipose_tissue_a_determinant_of_von_Willebrand_factor_in_overweight_and_obese_premenopausal_women L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(06)00012-6 DB - PRIME DP - Unbound Medicine ER -