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Baclofen analgesia in mice: a GABAB-mediated response.
Methods Find Exp Clin Pharmacol. 1991 Dec; 13(10):681-6.MF

Abstract

The effect of baclofen, a GABAB agonist, has been studied in three antinociceptive tests (tail flick latency, hot plate method and acetic acid-induced writhing) in mice. In all three models, baclofen was found to elicit a dose-dependent antinociceptive effect. The observed antinociceptive effect was stereospecific, as the levo isomer of baclofen was found to be more potent than the racemic mixture. Baclofen also potentiated morphine analgesia. The antinociceptive effect of baclofen was reversed by both CGP 35348, a GABAB antagonist, and naloxone, an opioid antagonist, but not by bicuculline or picrotoxin, GABAA antagonists. However, in acetic acid-induced writhing, naloxone failed to reverse baclofen analgesia. The data suggest that the antinociceptive effect of baclofen is GABAB receptor-mediated and that there may be a GABAergic and opiate/or non-opiate interaction in eliciting the analgesic effect.

Authors+Show Affiliations

Department of Pharmaceutical Sciences, Panjab University, Chandigarh, India.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1663195

Citation

Aley, K O., and S K. Kulkarni. "Baclofen Analgesia in Mice: a GABAB-mediated Response." Methods and Findings in Experimental and Clinical Pharmacology, vol. 13, no. 10, 1991, pp. 681-6.
Aley KO, Kulkarni SK. Baclofen analgesia in mice: a GABAB-mediated response. Methods Find Exp Clin Pharmacol. 1991;13(10):681-6.
Aley, K. O., & Kulkarni, S. K. (1991). Baclofen analgesia in mice: a GABAB-mediated response. Methods and Findings in Experimental and Clinical Pharmacology, 13(10), 681-6.
Aley KO, Kulkarni SK. Baclofen Analgesia in Mice: a GABAB-mediated Response. Methods Find Exp Clin Pharmacol. 1991;13(10):681-6. PubMed PMID: 1663195.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Baclofen analgesia in mice: a GABAB-mediated response. AU - Aley,K O, AU - Kulkarni,S K, PY - 1991/12/1/pubmed PY - 1991/12/1/medline PY - 1991/12/1/entrez SP - 681 EP - 6 JF - Methods and findings in experimental and clinical pharmacology JO - Methods Find Exp Clin Pharmacol VL - 13 IS - 10 N2 - The effect of baclofen, a GABAB agonist, has been studied in three antinociceptive tests (tail flick latency, hot plate method and acetic acid-induced writhing) in mice. In all three models, baclofen was found to elicit a dose-dependent antinociceptive effect. The observed antinociceptive effect was stereospecific, as the levo isomer of baclofen was found to be more potent than the racemic mixture. Baclofen also potentiated morphine analgesia. The antinociceptive effect of baclofen was reversed by both CGP 35348, a GABAB antagonist, and naloxone, an opioid antagonist, but not by bicuculline or picrotoxin, GABAA antagonists. However, in acetic acid-induced writhing, naloxone failed to reverse baclofen analgesia. The data suggest that the antinociceptive effect of baclofen is GABAB receptor-mediated and that there may be a GABAergic and opiate/or non-opiate interaction in eliciting the analgesic effect. SN - 0379-0355 UR - https://www.unboundmedicine.com/medline/citation/1663195/Baclofen_analgesia_in_mice:_a_GABAB_mediated_response_ L2 - https://medlineplus.gov/pain.html DB - PRIME DP - Unbound Medicine ER -