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Influence of chromium-enriched yeast on blood glucose and insulin variables, blood lipids, and markers of oxidative stress in subjects with type 2 diabetes mellitus.
Biol Trace Elem Res 2006; 109(3):215-30BT

Abstract

The aim of this study was to determine the effect of chromium (Cr)- enriched yeast on blood glucose and insulin variables, blood lipids, and blood markers of oxidative stress in persons with type 2 diabetes mellitus (median duration: 3.0 yr). Thirty-six subjects (9 men, 27 women; mean age: 61.3 yr; mean body mass index: 34.33 kg/m2) were supplemented with 400 microg Cr/d as Cr-enriched yeast (n = 19) or placebo (n = 17) for 12 wk in a randomized, double-blind study. The most interesting results were obtained by comparison of the change in the placebo group to the change in the Cr group. The Cr group showed a significantly greater increase in serum Cr compared to the placebo group (p < 0.05). Supplementation with Cr-enriched yeast was associated with a significant decrease in fasting serum glucose compared to placebo (p < 0.01). Blood markers of oxidative stress glutathione peroxidase activity and levels of reduced glutathione were essentially unchanged in the Cr group after 12 wk, but decreased significantly in the placebo group (p < 0.05, p < 0.01, respectively). Serum HbA1c and glycated protein (fructosamine) were essentially unchanged in the Cr group, whereas HbA1c tended to increase in the placebo group (from 6.94% to 7.11%). Fasting serum insulin decreased in both groups, with a greater tendency in the Cr group (-16.5% vs -9.5%). These data suggest that supplementation of well-controlled type 2 diabetics with Cr-enriched yeast is safe and can result in improvements in blood glucose variables and oxidative stress.

Authors+Show Affiliations

Institute of Clinical Biochemistry and Hematology, Charles University, Medical Faculty in Pilsen, Czech Republic.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16632892

Citation

Racek, Jaroslav, et al. "Influence of Chromium-enriched Yeast On Blood Glucose and Insulin Variables, Blood Lipids, and Markers of Oxidative Stress in Subjects With Type 2 Diabetes Mellitus." Biological Trace Element Research, vol. 109, no. 3, 2006, pp. 215-30.
Racek J, Trefil L, Rajdl D, et al. Influence of chromium-enriched yeast on blood glucose and insulin variables, blood lipids, and markers of oxidative stress in subjects with type 2 diabetes mellitus. Biol Trace Elem Res. 2006;109(3):215-30.
Racek, J., Trefil, L., Rajdl, D., Mudrová, V., Hunter, D., & Senft, V. (2006). Influence of chromium-enriched yeast on blood glucose and insulin variables, blood lipids, and markers of oxidative stress in subjects with type 2 diabetes mellitus. Biological Trace Element Research, 109(3), pp. 215-30.
Racek J, et al. Influence of Chromium-enriched Yeast On Blood Glucose and Insulin Variables, Blood Lipids, and Markers of Oxidative Stress in Subjects With Type 2 Diabetes Mellitus. Biol Trace Elem Res. 2006;109(3):215-30. PubMed PMID: 16632892.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of chromium-enriched yeast on blood glucose and insulin variables, blood lipids, and markers of oxidative stress in subjects with type 2 diabetes mellitus. AU - Racek,Jaroslav, AU - Trefil,Ladislav, AU - Rajdl,Daniel, AU - Mudrová,Vlasta, AU - Hunter,Douglas, AU - Senft,VáClav, PY - 2005/04/01/received PY - 2005/08/30/revised PY - 2005/09/20/accepted PY - 2006/4/25/pubmed PY - 2006/7/13/medline PY - 2006/4/25/entrez SP - 215 EP - 30 JF - Biological trace element research JO - Biol Trace Elem Res VL - 109 IS - 3 N2 - The aim of this study was to determine the effect of chromium (Cr)- enriched yeast on blood glucose and insulin variables, blood lipids, and blood markers of oxidative stress in persons with type 2 diabetes mellitus (median duration: 3.0 yr). Thirty-six subjects (9 men, 27 women; mean age: 61.3 yr; mean body mass index: 34.33 kg/m2) were supplemented with 400 microg Cr/d as Cr-enriched yeast (n = 19) or placebo (n = 17) for 12 wk in a randomized, double-blind study. The most interesting results were obtained by comparison of the change in the placebo group to the change in the Cr group. The Cr group showed a significantly greater increase in serum Cr compared to the placebo group (p < 0.05). Supplementation with Cr-enriched yeast was associated with a significant decrease in fasting serum glucose compared to placebo (p < 0.01). Blood markers of oxidative stress glutathione peroxidase activity and levels of reduced glutathione were essentially unchanged in the Cr group after 12 wk, but decreased significantly in the placebo group (p < 0.05, p < 0.01, respectively). Serum HbA1c and glycated protein (fructosamine) were essentially unchanged in the Cr group, whereas HbA1c tended to increase in the placebo group (from 6.94% to 7.11%). Fasting serum insulin decreased in both groups, with a greater tendency in the Cr group (-16.5% vs -9.5%). These data suggest that supplementation of well-controlled type 2 diabetics with Cr-enriched yeast is safe and can result in improvements in blood glucose variables and oxidative stress. SN - 0163-4984 UR - https://www.unboundmedicine.com/medline/citation/16632892/Influence_of_chromium_enriched_yeast_on_blood_glucose_and_insulin_variables_blood_lipids_and_markers_of_oxidative_stress_in_subjects_with_type_2_diabetes_mellitus_ L2 - https://dx.doi.org/10.1385/BTER:109:3:215 DB - PRIME DP - Unbound Medicine ER -