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Effect of laparoscopic Nissen fundoplication on symptoms and gastric myoelectric activity in gastroesophageal reflux disease.
J Clin Gastroenterol 2006; 40(4):301-5JC

Abstract

BACKGROUND

Laparoscopic Nissen fundoplication is an effective treatment for gastroesophageal reflux disease (GERD). The aim of this study was to determine whether laparoscopic fundoplication alters gastric myoelectric activity. Change of digestive symptoms was also assessed.

METHODS

Sixteen patients with GERD (2 males, 14 females, mean age: 53 years) undergoing a laparoscopic fundoplication participated. Electrogastrography (EGG) was assessed before and after the subject ingested water until full (water load). Symptoms of upper abdominal discomfort, early satiety, postprandial abdominal distension, nausea, vomiting, and anorexia were recorded. At a 2-month postoperative follow-up, preoperative tests were repeated.

RESULTS

The EGG was abnormal in 11 of 16 patients (69%) preoperatively and 6 of 16 patients (38%) postoperatively. The EGG changed from abnormal to normal in 5 of 16 patients (31%). The percentage of power at 3 cpm increased significantly during the fasting state postoperatively (29.9% vs. 21.2%, P < 0.05). There was a significant improvement in epigastric pain (P < 0.001), early satiety (P < 0.01), and postprandial fullness (P < 0.001).

CONCLUSIONS

Increased presence of normal 3 cpm activity is the predominant effect of fundoplication on gastric myoelectric activity. Dyspeptic symptoms are also significantly improved postoperatively.

Authors+Show Affiliations

Division of Gastroenterology and Hepatology, Buddhist Tzu Chi General Hospital and Medical School, Hualien, Taiwan. clchen@tzuchi.org.twNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16633101

Citation

Chen, Chien-Lin, et al. "Effect of Laparoscopic Nissen Fundoplication On Symptoms and Gastric Myoelectric Activity in Gastroesophageal Reflux Disease." Journal of Clinical Gastroenterology, vol. 40, no. 4, 2006, pp. 301-5.
Chen CL, Reif ME, Orr WC. Effect of laparoscopic Nissen fundoplication on symptoms and gastric myoelectric activity in gastroesophageal reflux disease. J Clin Gastroenterol. 2006;40(4):301-5.
Chen, C. L., Reif, M. E., & Orr, W. C. (2006). Effect of laparoscopic Nissen fundoplication on symptoms and gastric myoelectric activity in gastroesophageal reflux disease. Journal of Clinical Gastroenterology, 40(4), pp. 301-5.
Chen CL, Reif ME, Orr WC. Effect of Laparoscopic Nissen Fundoplication On Symptoms and Gastric Myoelectric Activity in Gastroesophageal Reflux Disease. J Clin Gastroenterol. 2006;40(4):301-5. PubMed PMID: 16633101.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of laparoscopic Nissen fundoplication on symptoms and gastric myoelectric activity in gastroesophageal reflux disease. AU - Chen,Chien-Lin, AU - Reif,Michael E, AU - Orr,William C, PY - 2006/4/25/pubmed PY - 2006/9/13/medline PY - 2006/4/25/entrez SP - 301 EP - 5 JF - Journal of clinical gastroenterology JO - J. Clin. Gastroenterol. VL - 40 IS - 4 N2 - BACKGROUND: Laparoscopic Nissen fundoplication is an effective treatment for gastroesophageal reflux disease (GERD). The aim of this study was to determine whether laparoscopic fundoplication alters gastric myoelectric activity. Change of digestive symptoms was also assessed. METHODS: Sixteen patients with GERD (2 males, 14 females, mean age: 53 years) undergoing a laparoscopic fundoplication participated. Electrogastrography (EGG) was assessed before and after the subject ingested water until full (water load). Symptoms of upper abdominal discomfort, early satiety, postprandial abdominal distension, nausea, vomiting, and anorexia were recorded. At a 2-month postoperative follow-up, preoperative tests were repeated. RESULTS: The EGG was abnormal in 11 of 16 patients (69%) preoperatively and 6 of 16 patients (38%) postoperatively. The EGG changed from abnormal to normal in 5 of 16 patients (31%). The percentage of power at 3 cpm increased significantly during the fasting state postoperatively (29.9% vs. 21.2%, P < 0.05). There was a significant improvement in epigastric pain (P < 0.001), early satiety (P < 0.01), and postprandial fullness (P < 0.001). CONCLUSIONS: Increased presence of normal 3 cpm activity is the predominant effect of fundoplication on gastric myoelectric activity. Dyspeptic symptoms are also significantly improved postoperatively. SN - 0192-0790 UR - https://www.unboundmedicine.com/medline/citation/16633101/Effect_of_laparoscopic_Nissen_fundoplication_on_symptoms_and_gastric_myoelectric_activity_in_gastroesophageal_reflux_disease_ L2 - http://Insights.ovid.com/pubmed?pmid=16633101 DB - PRIME DP - Unbound Medicine ER -