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Relationship between central corneal thickness and localized retinal nerve fiber layer defect in normal-tension glaucoma.
J Glaucoma 2006; 15(2):120-3JG

Abstract

PURPOSE

To determine whether central corneal thickness (CCT) is related to the extent of localized retinal nerve fiber layer (RNFL) defect at the initial examination of normal-tension glaucoma (NTG) patients.

PATIENTS AND METHODS

Seventy-five eyes of 75 NTG patients showing localized RNFL defects on RNFL photographs and corresponding visual field defects at the initial visit to a glaucoma specialist were selected for this study. All participants completed refraction, Goldmann applanation tonometry, CCT measurement, stereoscopic disc photography, RNFL photography, and automated perimetry. Each patient's age, spherical equivalent, intraocular pressure, CCT, approximation of the RNFL defect to the fovea (angle alpha), circumferential width of the RNFL defects (angle beta), horizontal and vertical cup-to-disc ratios, and mean deviation of visual field were analyzed.

RESULTS

In univariate and multivariate analyses, lower CCT was significantly associated with increased horizontal and vertical cup-to-disc ratios, decreased angle alpha, and increased angle beta. For a decrease of 10 microm of CCT, horizontal and vertical cup-to-disc ratios increased by 0.020, angle alpha decreased by 1.58 degrees, and angle beta increased by 1.71 degrees, respectively.

CONCLUSION

CCT is a significant factor in predicting the extent of localized RNFL defect at the initial examination of NTG patients.

Authors+Show Affiliations

Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16633225

Citation

Choi, Hyuk Jin, et al. "Relationship Between Central Corneal Thickness and Localized Retinal Nerve Fiber Layer Defect in Normal-tension Glaucoma." Journal of Glaucoma, vol. 15, no. 2, 2006, pp. 120-3.
Choi HJ, Kim DM, Hwang SS. Relationship between central corneal thickness and localized retinal nerve fiber layer defect in normal-tension glaucoma. J Glaucoma. 2006;15(2):120-3.
Choi, H. J., Kim, D. M., & Hwang, S. S. (2006). Relationship between central corneal thickness and localized retinal nerve fiber layer defect in normal-tension glaucoma. Journal of Glaucoma, 15(2), pp. 120-3.
Choi HJ, Kim DM, Hwang SS. Relationship Between Central Corneal Thickness and Localized Retinal Nerve Fiber Layer Defect in Normal-tension Glaucoma. J Glaucoma. 2006;15(2):120-3. PubMed PMID: 16633225.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between central corneal thickness and localized retinal nerve fiber layer defect in normal-tension glaucoma. AU - Choi,Hyuk Jin, AU - Kim,Dong Myung, AU - Hwang,Seung-Sik, PY - 2006/4/25/pubmed PY - 2006/6/6/medline PY - 2006/4/25/entrez SP - 120 EP - 3 JF - Journal of glaucoma JO - J. Glaucoma VL - 15 IS - 2 N2 - PURPOSE: To determine whether central corneal thickness (CCT) is related to the extent of localized retinal nerve fiber layer (RNFL) defect at the initial examination of normal-tension glaucoma (NTG) patients. PATIENTS AND METHODS: Seventy-five eyes of 75 NTG patients showing localized RNFL defects on RNFL photographs and corresponding visual field defects at the initial visit to a glaucoma specialist were selected for this study. All participants completed refraction, Goldmann applanation tonometry, CCT measurement, stereoscopic disc photography, RNFL photography, and automated perimetry. Each patient's age, spherical equivalent, intraocular pressure, CCT, approximation of the RNFL defect to the fovea (angle alpha), circumferential width of the RNFL defects (angle beta), horizontal and vertical cup-to-disc ratios, and mean deviation of visual field were analyzed. RESULTS: In univariate and multivariate analyses, lower CCT was significantly associated with increased horizontal and vertical cup-to-disc ratios, decreased angle alpha, and increased angle beta. For a decrease of 10 microm of CCT, horizontal and vertical cup-to-disc ratios increased by 0.020, angle alpha decreased by 1.58 degrees, and angle beta increased by 1.71 degrees, respectively. CONCLUSION: CCT is a significant factor in predicting the extent of localized RNFL defect at the initial examination of NTG patients. SN - 1057-0829 UR - https://www.unboundmedicine.com/medline/citation/16633225/Relationship_between_central_corneal_thickness_and_localized_retinal_nerve_fiber_layer_defect_in_normal_tension_glaucoma_ L2 - http://Insights.ovid.com/pubmed?pmid=16633225 DB - PRIME DP - Unbound Medicine ER -