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Antioxidative and anti-diabetic effects of amaranth (Amaranthus esculantus) in streptozotocin-induced diabetic rats.
Cell Biochem Funct. 2006 May-Jun; 24(3):195-9.CB

Abstract

The anti-diabetic and antioxidative effect of amaranth grain (AG) and its oil fraction (AO) was studied in streptozotocin-induced diabetic rats. Male Sprague-Dawley rats were divided into four groups after induction of STZ-diabetes: normal control; diabetic control; diabetic-AG supplement (500 g kg(-1) diet); diabetic-AO supplement (100 g kg(-1) diet) and fed experimental diets for 3 weeks. Serum glucose, insulin, activities of serum marker enzymes of liver function and liver cytosolic antioxidant enzymes were measured. The AG and AO supplement significantly decreased the serum glucose and increased serum insulin level in diabetic rats. Serum concentration of liver function marker enzymes, GOT and GPT, were also normalized by AG and AO treatment in diabetic rats. Liver cytosolic SOD and GSH-reductase activities were significantly increased, and catalase, peroxidase and GSH-Px activities were decreased in diabetic rats. AG and AO supplement reverted the antioxidant enzyme activities to near normal values. Hepatic lipid peroxide product was significantly higher, and GSH content was decreased in diabetic rats. However, AG and AO supplement normalized these values. Our data suggest that AG and AO supplement, as an antioxidant therapy, may be beneficial for correcting hyperglycaemia and preventing diabetic complications.

Authors+Show Affiliations

Department of Food and Biotechnology, Hanseo University, Seosan, 356-820 Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16634092

Citation

Kim, Hye Kyung, et al. "Antioxidative and Anti-diabetic Effects of Amaranth (Amaranthus Esculantus) in Streptozotocin-induced Diabetic Rats." Cell Biochemistry and Function, vol. 24, no. 3, 2006, pp. 195-9.
Kim HK, Kim MJ, Cho HY, et al. Antioxidative and anti-diabetic effects of amaranth (Amaranthus esculantus) in streptozotocin-induced diabetic rats. Cell Biochem Funct. 2006;24(3):195-9.
Kim, H. K., Kim, M. J., Cho, H. Y., Kim, E. K., & Shin, D. H. (2006). Antioxidative and anti-diabetic effects of amaranth (Amaranthus esculantus) in streptozotocin-induced diabetic rats. Cell Biochemistry and Function, 24(3), 195-9.
Kim HK, et al. Antioxidative and Anti-diabetic Effects of Amaranth (Amaranthus Esculantus) in Streptozotocin-induced Diabetic Rats. Cell Biochem Funct. 2006 May-Jun;24(3):195-9. PubMed PMID: 16634092.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidative and anti-diabetic effects of amaranth (Amaranthus esculantus) in streptozotocin-induced diabetic rats. AU - Kim,Hye Kyung, AU - Kim,Mi Jeong, AU - Cho,Hong Yon, AU - Kim,Eun-Ki, AU - Shin,Dong Hoon, PY - 2006/4/25/pubmed PY - 2006/7/26/medline PY - 2006/4/25/entrez SP - 195 EP - 9 JF - Cell biochemistry and function JO - Cell Biochem Funct VL - 24 IS - 3 N2 - The anti-diabetic and antioxidative effect of amaranth grain (AG) and its oil fraction (AO) was studied in streptozotocin-induced diabetic rats. Male Sprague-Dawley rats were divided into four groups after induction of STZ-diabetes: normal control; diabetic control; diabetic-AG supplement (500 g kg(-1) diet); diabetic-AO supplement (100 g kg(-1) diet) and fed experimental diets for 3 weeks. Serum glucose, insulin, activities of serum marker enzymes of liver function and liver cytosolic antioxidant enzymes were measured. The AG and AO supplement significantly decreased the serum glucose and increased serum insulin level in diabetic rats. Serum concentration of liver function marker enzymes, GOT and GPT, were also normalized by AG and AO treatment in diabetic rats. Liver cytosolic SOD and GSH-reductase activities were significantly increased, and catalase, peroxidase and GSH-Px activities were decreased in diabetic rats. AG and AO supplement reverted the antioxidant enzyme activities to near normal values. Hepatic lipid peroxide product was significantly higher, and GSH content was decreased in diabetic rats. However, AG and AO supplement normalized these values. Our data suggest that AG and AO supplement, as an antioxidant therapy, may be beneficial for correcting hyperglycaemia and preventing diabetic complications. SN - 0263-6484 UR - https://www.unboundmedicine.com/medline/citation/16634092/Antioxidative_and_anti_diabetic_effects_of_amaranth__Amaranthus_esculantus__in_streptozotocin_induced_diabetic_rats_ L2 - https://doi.org/10.1002/cbf.1210 DB - PRIME DP - Unbound Medicine ER -