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Beneficial effect of low-dose ketamine addition to epidural administration of morphine-bupivacaine mixture for cancer pain in two cases.
Pain Med. 2006 Mar-Apr; 7(2):166-9.PM

Abstract

Two patients experiencing cancer pain with neuropathic components were treated with epidural administration of a mixture of ketamine (1 mg/mL) + morphine (1 mg/mL) + bupivacaine (1 mg/mL) injected daily by epidural port. No serious adverse effect was observed throughout the therapy. The patients were mostly pain-free and have gotten better quality of life during 110- and 48-day follow-up when the therapy was given by epidural route. Low doses of epidural ketamine added to morphine and bupivacaine increase the mean duration of satisfactory analgesia without severe adverse effects and restore quality of life when traditional therapy fails.

Authors+Show Affiliations

Sen S
Department of Anesthesiology and Reanimation, State Hospital Anesthesiology and Reanimation Clinic, Adnan Menderes University, Medical Faculty, Aydin, Turkey. drseldasen@yahoo.com
Aydin ON
No affiliation info available
Aydin K
No affiliation info available

MeSH

AdultAnalgesia, EpiduralAnalgesicsAnalgesics, OpioidAnesthetics, LocalBupivacaineColonic NeoplasmsDose-Response Relationship, DrugDrug CombinationsFatal OutcomeHumansKetamineLung NeoplasmsMaleMiddle AgedMorphineNeoplasm MetastasisNeoplasmsPain, IntractableQuality of LifeSpinal Cord CompressionSpinal NeoplasmsTerminal CareTreatment Outcome

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

16634730

Citation

Sen, Selda, et al. "Beneficial Effect of Low-dose Ketamine Addition to Epidural Administration of Morphine-bupivacaine Mixture for Cancer Pain in Two Cases." Pain Medicine (Malden, Mass.), vol. 7, no. 2, 2006, pp. 166-9.
Sen S, Aydin ON, Aydin K. Beneficial effect of low-dose ketamine addition to epidural administration of morphine-bupivacaine mixture for cancer pain in two cases. Pain Med. 2006;7(2):166-9.
Sen, S., Aydin, O. N., & Aydin, K. (2006). Beneficial effect of low-dose ketamine addition to epidural administration of morphine-bupivacaine mixture for cancer pain in two cases. Pain Medicine (Malden, Mass.), 7(2), 166-9.
Sen S, Aydin ON, Aydin K. Beneficial Effect of Low-dose Ketamine Addition to Epidural Administration of Morphine-bupivacaine Mixture for Cancer Pain in Two Cases. Pain Med. 2006 Mar-Apr;7(2):166-9. PubMed PMID: 16634730.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Beneficial effect of low-dose ketamine addition to epidural administration of morphine-bupivacaine mixture for cancer pain in two cases. AU - Sen,Selda, AU - Aydin,Osman N, AU - Aydin,Kutlay, PY - 2006/4/26/pubmed PY - 2006/6/10/medline PY - 2006/4/26/entrez SP - 166 EP - 9 JF - Pain medicine (Malden, Mass.) JO - Pain Med VL - 7 IS - 2 N2 - Two patients experiencing cancer pain with neuropathic components were treated with epidural administration of a mixture of ketamine (1 mg/mL) + morphine (1 mg/mL) + bupivacaine (1 mg/mL) injected daily by epidural port. No serious adverse effect was observed throughout the therapy. The patients were mostly pain-free and have gotten better quality of life during 110- and 48-day follow-up when the therapy was given by epidural route. Low doses of epidural ketamine added to morphine and bupivacaine increase the mean duration of satisfactory analgesia without severe adverse effects and restore quality of life when traditional therapy fails. SN - 1526-2375 UR - https://www.unboundmedicine.com/medline/citation/16634730/Beneficial_effect_of_low_dose_ketamine_addition_to_epidural_administration_of_morphine_bupivacaine_mixture_for_cancer_pain_in_two_cases_ DB - PRIME DP - Unbound Medicine ER -