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Effects of a cinnamon extract on plasma glucose, HbA, and serum lipids in diabetes mellitus type 2.
Eur J Clin Invest. 2006 May; 36(5):340-4.EJ

Abstract

BACKGROUND

According to previous studies, cinnamon may have a positive effect on the glycaemic control and the lipid profile in patients with diabetes mellitus type 2. The aim of this trial was to determine whether an aqueous cinnamon purified extract improves glycated haemoglobin A1c (HbA1c), fasting plasma glucose, total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL) and triacylglycerol concentrations in patients with type 2 diabetes.

METHODS

A total of 79 patients with diagnosed diabetes mellitus type 2 not on insulin therapy but treated with oral antidiabetics or diet were randomly assigned to take either a cinnamon extract or a placebo capsule three times a day for 4 months in a double-blind study. The amount of aqueous cinnamon extract corresponded to 3 g of cinnamon powder per day.

RESULTS

The mean absolute and percentage differences between the pre- and post-intervention fasting plasma glucose level of the cinnamon and placebo groups were significantly different. There was a significantly higher reduction in the cinnamon group (10.3%) than in the placebo group (3.4%). No significant intragroup or intergroup differences were observed regarding HbA1c, lipid profiles or differences between the pre- and postintervention levels of these variables. The decrease in plasma glucose correlated significantly with the baseline concentrations, indicating that subjects with a higher initial plasma glucose level may benefit more from cinnamon intake. No adverse effects were observed.

CONCLUSIONS

The cinnamon extract seems to have a moderate effect in reducing fasting plasma glucose concentrations in diabetic patients with poor glycaemic control.

Authors+Show Affiliations

Nutrition Physiology and Human Nutrition Unit, Institute of Food Science, University of Hannover, Hannover, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16634838

Citation

Mang, B, et al. "Effects of a Cinnamon Extract On Plasma Glucose, HbA, and Serum Lipids in Diabetes Mellitus Type 2." European Journal of Clinical Investigation, vol. 36, no. 5, 2006, pp. 340-4.
Mang B, Wolters M, Schmitt B, et al. Effects of a cinnamon extract on plasma glucose, HbA, and serum lipids in diabetes mellitus type 2. Eur J Clin Invest. 2006;36(5):340-4.
Mang, B., Wolters, M., Schmitt, B., Kelb, K., Lichtinghagen, R., Stichtenoth, D. O., & Hahn, A. (2006). Effects of a cinnamon extract on plasma glucose, HbA, and serum lipids in diabetes mellitus type 2. European Journal of Clinical Investigation, 36(5), 340-4.
Mang B, et al. Effects of a Cinnamon Extract On Plasma Glucose, HbA, and Serum Lipids in Diabetes Mellitus Type 2. Eur J Clin Invest. 2006;36(5):340-4. PubMed PMID: 16634838.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of a cinnamon extract on plasma glucose, HbA, and serum lipids in diabetes mellitus type 2. AU - Mang,B, AU - Wolters,M, AU - Schmitt,B, AU - Kelb,K, AU - Lichtinghagen,R, AU - Stichtenoth,D O, AU - Hahn,A, PY - 2006/4/26/pubmed PY - 2006/9/16/medline PY - 2006/4/26/entrez SP - 340 EP - 4 JF - European journal of clinical investigation JO - Eur J Clin Invest VL - 36 IS - 5 N2 - BACKGROUND: According to previous studies, cinnamon may have a positive effect on the glycaemic control and the lipid profile in patients with diabetes mellitus type 2. The aim of this trial was to determine whether an aqueous cinnamon purified extract improves glycated haemoglobin A1c (HbA1c), fasting plasma glucose, total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL) and triacylglycerol concentrations in patients with type 2 diabetes. METHODS: A total of 79 patients with diagnosed diabetes mellitus type 2 not on insulin therapy but treated with oral antidiabetics or diet were randomly assigned to take either a cinnamon extract or a placebo capsule three times a day for 4 months in a double-blind study. The amount of aqueous cinnamon extract corresponded to 3 g of cinnamon powder per day. RESULTS: The mean absolute and percentage differences between the pre- and post-intervention fasting plasma glucose level of the cinnamon and placebo groups were significantly different. There was a significantly higher reduction in the cinnamon group (10.3%) than in the placebo group (3.4%). No significant intragroup or intergroup differences were observed regarding HbA1c, lipid profiles or differences between the pre- and postintervention levels of these variables. The decrease in plasma glucose correlated significantly with the baseline concentrations, indicating that subjects with a higher initial plasma glucose level may benefit more from cinnamon intake. No adverse effects were observed. CONCLUSIONS: The cinnamon extract seems to have a moderate effect in reducing fasting plasma glucose concentrations in diabetic patients with poor glycaemic control. SN - 0014-2972 UR - https://www.unboundmedicine.com/medline/citation/16634838/Effects_of_a_cinnamon_extract_on_plasma_glucose_HbA_and_serum_lipids_in_diabetes_mellitus_type_2_ L2 - https://doi.org/10.1111/j.1365-2362.2006.01629.x DB - PRIME DP - Unbound Medicine ER -