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Influence of naringenin on oxytetracycline mediated oxidative damage in rat liver.

Abstract

Naringenin is a naturally occurring citrus flavanone, which has been reported to have a wide range of pharmacological properties. The present work was carried out to evaluate the effect of naringenin on antioxidant and lipid peroxidation status in liver of oxytetracycline-intoxicated rats. Intraperitonial administration of oxytetracycline 200 mg/kg for 15 days resulted a significant elevation in serum hepatospecific markers such as aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase, and bilirubin and the levels of lipid peroxidation markers (thiobarbituric acid reactive substances (TBARS) and lipid hydroperoxides) in liver. Oxytetracycline also caused a significant reduction in the activities of superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione (GSH), vitamin C and vitamin E in liver. Oral administration of naringenin (50 mg/kg b.w.t.) with oxytetracycline significantly decreased the activities of serum aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase and the levels of bilirubin along with significant decrease in the levels of lipid peroxidation markers in the liver. In addition, naringenin significantly increased the activities of superoxide dismutase, catalase and GSH peroxidase as well as the level of GSH, vitamin C and vitamin E in liver of the oxytetracycline-treated rats. Our results demonstrate that naringenin exhibited antioxidant property and decrease the lipid peroxidation against oxytetracycline-induced oxidative stress in liver.

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  • Authors+Show Affiliations

    ,

    Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar - 608002, Tamilnadu, India. paribalaji@gmail.com

    Source

    MeSH

    Animals
    Anti-Bacterial Agents
    Antioxidants
    Catalase
    Chemical and Drug Induced Liver Injury
    Flavanones
    Glutathione
    Glutathione Peroxidase
    Lipid Peroxidation
    Liver
    Liver Diseases
    Male
    Oxidative Stress
    Oxytetracycline
    Rats
    Rats, Wistar
    Superoxide Dismutase

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    16635103

    Citation

    Pari, Leelavinothan, and Muthurangam Gnanasoundari. "Influence of Naringenin On Oxytetracycline Mediated Oxidative Damage in Rat Liver." Basic & Clinical Pharmacology & Toxicology, vol. 98, no. 5, 2006, pp. 456-61.
    Pari L, Gnanasoundari M. Influence of naringenin on oxytetracycline mediated oxidative damage in rat liver. Basic Clin Pharmacol Toxicol. 2006;98(5):456-61.
    Pari, L., & Gnanasoundari, M. (2006). Influence of naringenin on oxytetracycline mediated oxidative damage in rat liver. Basic & Clinical Pharmacology & Toxicology, 98(5), pp. 456-61.
    Pari L, Gnanasoundari M. Influence of Naringenin On Oxytetracycline Mediated Oxidative Damage in Rat Liver. Basic Clin Pharmacol Toxicol. 2006;98(5):456-61. PubMed PMID: 16635103.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Influence of naringenin on oxytetracycline mediated oxidative damage in rat liver. AU - Pari,Leelavinothan, AU - Gnanasoundari,Muthurangam, PY - 2006/4/26/pubmed PY - 2006/12/9/medline PY - 2006/4/26/entrez SP - 456 EP - 61 JF - Basic & clinical pharmacology & toxicology JO - Basic Clin. Pharmacol. Toxicol. VL - 98 IS - 5 N2 - Naringenin is a naturally occurring citrus flavanone, which has been reported to have a wide range of pharmacological properties. The present work was carried out to evaluate the effect of naringenin on antioxidant and lipid peroxidation status in liver of oxytetracycline-intoxicated rats. Intraperitonial administration of oxytetracycline 200 mg/kg for 15 days resulted a significant elevation in serum hepatospecific markers such as aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase, and bilirubin and the levels of lipid peroxidation markers (thiobarbituric acid reactive substances (TBARS) and lipid hydroperoxides) in liver. Oxytetracycline also caused a significant reduction in the activities of superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione (GSH), vitamin C and vitamin E in liver. Oral administration of naringenin (50 mg/kg b.w.t.) with oxytetracycline significantly decreased the activities of serum aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase and the levels of bilirubin along with significant decrease in the levels of lipid peroxidation markers in the liver. In addition, naringenin significantly increased the activities of superoxide dismutase, catalase and GSH peroxidase as well as the level of GSH, vitamin C and vitamin E in liver of the oxytetracycline-treated rats. Our results demonstrate that naringenin exhibited antioxidant property and decrease the lipid peroxidation against oxytetracycline-induced oxidative stress in liver. SN - 1742-7835 UR - https://www.unboundmedicine.com/medline/citation/16635103/Influence_of_naringenin_on_oxytetracycline_mediated_oxidative_damage_in_rat_liver_ L2 - https://doi.org/10.1111/j.1742-7843.2006.pto_351.x DB - PRIME DP - Unbound Medicine ER -