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Influence of naringenin on oxytetracycline mediated oxidative damage in rat liver.
Basic Clin Pharmacol Toxicol 2006; 98(5):456-61BC

Abstract

Naringenin is a naturally occurring citrus flavanone, which has been reported to have a wide range of pharmacological properties. The present work was carried out to evaluate the effect of naringenin on antioxidant and lipid peroxidation status in liver of oxytetracycline-intoxicated rats. Intraperitonial administration of oxytetracycline 200 mg/kg for 15 days resulted a significant elevation in serum hepatospecific markers such as aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase, and bilirubin and the levels of lipid peroxidation markers (thiobarbituric acid reactive substances (TBARS) and lipid hydroperoxides) in liver. Oxytetracycline also caused a significant reduction in the activities of superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione (GSH), vitamin C and vitamin E in liver. Oral administration of naringenin (50 mg/kg b.w.t.) with oxytetracycline significantly decreased the activities of serum aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase and the levels of bilirubin along with significant decrease in the levels of lipid peroxidation markers in the liver. In addition, naringenin significantly increased the activities of superoxide dismutase, catalase and GSH peroxidase as well as the level of GSH, vitamin C and vitamin E in liver of the oxytetracycline-treated rats. Our results demonstrate that naringenin exhibited antioxidant property and decrease the lipid peroxidation against oxytetracycline-induced oxidative stress in liver.

Authors+Show Affiliations

Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar - 608002, Tamilnadu, India. paribalaji@gmail.comNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16635103

Citation

Pari, Leelavinothan, and Muthurangam Gnanasoundari. "Influence of Naringenin On Oxytetracycline Mediated Oxidative Damage in Rat Liver." Basic & Clinical Pharmacology & Toxicology, vol. 98, no. 5, 2006, pp. 456-61.
Pari L, Gnanasoundari M. Influence of naringenin on oxytetracycline mediated oxidative damage in rat liver. Basic Clin Pharmacol Toxicol. 2006;98(5):456-61.
Pari, L., & Gnanasoundari, M. (2006). Influence of naringenin on oxytetracycline mediated oxidative damage in rat liver. Basic & Clinical Pharmacology & Toxicology, 98(5), pp. 456-61.
Pari L, Gnanasoundari M. Influence of Naringenin On Oxytetracycline Mediated Oxidative Damage in Rat Liver. Basic Clin Pharmacol Toxicol. 2006;98(5):456-61. PubMed PMID: 16635103.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of naringenin on oxytetracycline mediated oxidative damage in rat liver. AU - Pari,Leelavinothan, AU - Gnanasoundari,Muthurangam, PY - 2006/4/26/pubmed PY - 2006/12/9/medline PY - 2006/4/26/entrez SP - 456 EP - 61 JF - Basic & clinical pharmacology & toxicology JO - Basic Clin. Pharmacol. Toxicol. VL - 98 IS - 5 N2 - Naringenin is a naturally occurring citrus flavanone, which has been reported to have a wide range of pharmacological properties. The present work was carried out to evaluate the effect of naringenin on antioxidant and lipid peroxidation status in liver of oxytetracycline-intoxicated rats. Intraperitonial administration of oxytetracycline 200 mg/kg for 15 days resulted a significant elevation in serum hepatospecific markers such as aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase, and bilirubin and the levels of lipid peroxidation markers (thiobarbituric acid reactive substances (TBARS) and lipid hydroperoxides) in liver. Oxytetracycline also caused a significant reduction in the activities of superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione (GSH), vitamin C and vitamin E in liver. Oral administration of naringenin (50 mg/kg b.w.t.) with oxytetracycline significantly decreased the activities of serum aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase and the levels of bilirubin along with significant decrease in the levels of lipid peroxidation markers in the liver. In addition, naringenin significantly increased the activities of superoxide dismutase, catalase and GSH peroxidase as well as the level of GSH, vitamin C and vitamin E in liver of the oxytetracycline-treated rats. Our results demonstrate that naringenin exhibited antioxidant property and decrease the lipid peroxidation against oxytetracycline-induced oxidative stress in liver. SN - 1742-7835 UR - https://www.unboundmedicine.com/medline/citation/16635103/Influence_of_naringenin_on_oxytetracycline_mediated_oxidative_damage_in_rat_liver_ L2 - https://doi.org/10.1111/j.1742-7843.2006.pto_351.x DB - PRIME DP - Unbound Medicine ER -