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Protective effects of ethanolic neem leaf extract on DMBA-induced genotoxicity and oxidative stress in mice.
J Herb Pharmacother. 2005; 5(4):39-50.JH

Abstract

We evaluated the effects of pretreatment with ethanolic neem leaf extract on 7,12-dimethylbenz[a]anthracene (DMBA)-induced genotoxicity and oxidative stress in male Swiss albino mice. The frequency of bone marrow micronuclei, the extent of hepatic lipid peroxidation and the status of antioxidants-reduced glutathione (GSH), glutathione peroxidase (GPx) and glutathione-S-transferase (GST) were used as intermediate biomarkers of chemoprotection. In DMBA-treated mice, the increases in micronuclei and lipid peroxides were accompanied by compromised antioxidant defenses. Pretreatment with ethanolic neem leaf extract (200 mg/kg body weight) significantly reduced DMBA-induced micronuclei and lipid peroxides and enhanced GSH-dependent antioxidant activities. The results of the present study suggest that ethanolic neem leaf extract exerts protective effects against DMBA-induced genotoxicity and oxidative stress by enhancing the antioxidant status.

Authors+Show Affiliations

Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, 608 002, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16635967

Citation

Subapriya, Rajamanickam, et al. "Protective Effects of Ethanolic Neem Leaf Extract On DMBA-induced Genotoxicity and Oxidative Stress in Mice." Journal of Herbal Pharmacotherapy, vol. 5, no. 4, 2005, pp. 39-50.
Subapriya R, Kumaraguruparan R, Abraham SK, et al. Protective effects of ethanolic neem leaf extract on DMBA-induced genotoxicity and oxidative stress in mice. J Herb Pharmacother. 2005;5(4):39-50.
Subapriya, R., Kumaraguruparan, R., Abraham, S. K., & Nagini, S. (2005). Protective effects of ethanolic neem leaf extract on DMBA-induced genotoxicity and oxidative stress in mice. Journal of Herbal Pharmacotherapy, 5(4), 39-50.
Subapriya R, et al. Protective Effects of Ethanolic Neem Leaf Extract On DMBA-induced Genotoxicity and Oxidative Stress in Mice. J Herb Pharmacother. 2005;5(4):39-50. PubMed PMID: 16635967.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effects of ethanolic neem leaf extract on DMBA-induced genotoxicity and oxidative stress in mice. AU - Subapriya,Rajamanickam, AU - Kumaraguruparan,Ramasamy, AU - Abraham,Suresh K, AU - Nagini,Siddavaram, PY - 2006/4/26/pubmed PY - 2006/8/30/medline PY - 2006/4/26/entrez SP - 39 EP - 50 JF - Journal of herbal pharmacotherapy JO - J Herb Pharmacother VL - 5 IS - 4 N2 - We evaluated the effects of pretreatment with ethanolic neem leaf extract on 7,12-dimethylbenz[a]anthracene (DMBA)-induced genotoxicity and oxidative stress in male Swiss albino mice. The frequency of bone marrow micronuclei, the extent of hepatic lipid peroxidation and the status of antioxidants-reduced glutathione (GSH), glutathione peroxidase (GPx) and glutathione-S-transferase (GST) were used as intermediate biomarkers of chemoprotection. In DMBA-treated mice, the increases in micronuclei and lipid peroxides were accompanied by compromised antioxidant defenses. Pretreatment with ethanolic neem leaf extract (200 mg/kg body weight) significantly reduced DMBA-induced micronuclei and lipid peroxides and enhanced GSH-dependent antioxidant activities. The results of the present study suggest that ethanolic neem leaf extract exerts protective effects against DMBA-induced genotoxicity and oxidative stress by enhancing the antioxidant status. SN - 1522-8940 UR - https://www.unboundmedicine.com/medline/citation/16635967/Protective_effects_of_ethanolic_neem_leaf_extract_on_DMBA_induced_genotoxicity_and_oxidative_stress_in_mice_ L2 - https://medlineplus.gov/herbalmedicine.html DB - PRIME DP - Unbound Medicine ER -