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Creatine kinase mb, cardiac troponin T and cardiac troponin I as the markers of rhabdomyolysis in chronic hemodialysis patients.
Georgian Med News. 2006 MarGM

Abstract

We designed this study to compare serum markers of myocardial injury creatine kinase MB (CK-MB), as well, as serum contractile proteins, especially cardiac troponin T (cTnT) and cardiac troponin I (cTnI) in dialysis patients without acute ischemic heart disease. 24 patients on chronic hemodialysis were studied by history and physical examination, electrocardiography, and two-dimensional echocardiography. These patients had no evidence of ischemic heart disease. Biochemical markers were measured in serial predialysis blood samples with specific monoclonal antibody-based immunoassays. For several patients at least one sample measured above the upper reference limit: CK-MB, 7 of 24 (30%); ELISA cTnT, 17 of 24 (71%); Enzymun cTnT, 3 of 18 (17%); and cTnI, 1 of 24 (4%). Chronic dialysis patients without acute ischemic heart disease frequently had increased serum CK-MB and cTnT. Our finding are in agreement with the conclusions that cTnT and CK-MB detected in the serum of patients on chronic hemodialysis originates from the skeletal muscle and not from the heart.

Authors+Show Affiliations

Department of Hemodialysis and Detoxication, Tbilisis State Medical University Clinic, Georgia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16636385

Citation

Sutidze, M, et al. "Creatine Kinase Mb, Cardiac Troponin T and Cardiac Troponin I as the Markers of Rhabdomyolysis in Chronic Hemodialysis Patients." Georgian Medical News, 2006, pp. 68-71.
Sutidze M, Sulakvelidze M, Kochiashvili D, et al. Creatine kinase mb, cardiac troponin T and cardiac troponin I as the markers of rhabdomyolysis in chronic hemodialysis patients. Georgian Med News. 2006.
Sutidze, M., Sulakvelidze, M., Kochiashvili, D., Labadze, D., & Rukhadze, I. (2006). Creatine kinase mb, cardiac troponin T and cardiac troponin I as the markers of rhabdomyolysis in chronic hemodialysis patients. Georgian Medical News, (132), 68-71.
Sutidze M, et al. Creatine Kinase Mb, Cardiac Troponin T and Cardiac Troponin I as the Markers of Rhabdomyolysis in Chronic Hemodialysis Patients. Georgian Med News. 2006;(132)68-71. PubMed PMID: 16636385.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Creatine kinase mb, cardiac troponin T and cardiac troponin I as the markers of rhabdomyolysis in chronic hemodialysis patients. AU - Sutidze,M, AU - Sulakvelidze,M, AU - Kochiashvili,D, AU - Labadze,D, AU - Rukhadze,I, PY - 2006/4/26/pubmed PY - 2006/7/13/medline PY - 2006/4/26/entrez SP - 68 EP - 71 JF - Georgian medical news JO - Georgian Med News IS - 132 N2 - We designed this study to compare serum markers of myocardial injury creatine kinase MB (CK-MB), as well, as serum contractile proteins, especially cardiac troponin T (cTnT) and cardiac troponin I (cTnI) in dialysis patients without acute ischemic heart disease. 24 patients on chronic hemodialysis were studied by history and physical examination, electrocardiography, and two-dimensional echocardiography. These patients had no evidence of ischemic heart disease. Biochemical markers were measured in serial predialysis blood samples with specific monoclonal antibody-based immunoassays. For several patients at least one sample measured above the upper reference limit: CK-MB, 7 of 24 (30%); ELISA cTnT, 17 of 24 (71%); Enzymun cTnT, 3 of 18 (17%); and cTnI, 1 of 24 (4%). Chronic dialysis patients without acute ischemic heart disease frequently had increased serum CK-MB and cTnT. Our finding are in agreement with the conclusions that cTnT and CK-MB detected in the serum of patients on chronic hemodialysis originates from the skeletal muscle and not from the heart. SN - 1512-0112 UR - https://www.unboundmedicine.com/medline/citation/16636385/Creatine_kinase_mb_cardiac_troponin_T_and_cardiac_troponin_I_as_the_markers_of_rhabdomyolysis_in_chronic_hemodialysis_patients_ L2 - http://www.diseaseinfosearch.org/result/9690 DB - PRIME DP - Unbound Medicine ER -