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Capsiate, a nonpungent capsaicin analog, increases endurance swimming capacity of mice by stimulation of vanilloid receptors.
Biosci Biotechnol Biochem. 2006 Apr; 70(4):774-81.BB

Abstract

We investigated the effect of capsiate, a nonpungent natural capsaicin analog, on the swimming capacity of mice in an adjustable-current water pool. Male BALB/c mice orally given capsiate (10 mg/kg) were able to keep swimming longer before exhaustion than the control mice. After 30 min of swimming, the residual glycogen in the gastrocnemius muscle was higher, the serum free fatty acid concentration tended to be higher, and the serum lactic acid concentration was significantly lower in the capsiate-administered mice. The value for the respiratory exchange ratio of the capsiate group was significantly lower during both resting and treadmill running. These physiological differences were abolished by administering the vanilloid receptor antagonist, capsazepin (0.17 mmol/kg, i.p.). The mice were not averse to the capsiate solution during a 4-h two-bottle choice test. These results suggest that the oral administration of capsiate enhanced fat oxidation and spared carbohydrate utilization, and consequently increased the endurance swimming capacity of the mice via stimulation of their vanilloid receptors. Practical application of capsiate is expected.

Authors+Show Affiliations

Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16636441

Citation

Haramizu, Satoshi, et al. "Capsiate, a Nonpungent Capsaicin Analog, Increases Endurance Swimming Capacity of Mice By Stimulation of Vanilloid Receptors." Bioscience, Biotechnology, and Biochemistry, vol. 70, no. 4, 2006, pp. 774-81.
Haramizu S, Mizunoya W, Masuda Y, et al. Capsiate, a nonpungent capsaicin analog, increases endurance swimming capacity of mice by stimulation of vanilloid receptors. Biosci Biotechnol Biochem. 2006;70(4):774-81.
Haramizu, S., Mizunoya, W., Masuda, Y., Ohnuki, K., Watanabe, T., Yazawa, S., & Fushiki, T. (2006). Capsiate, a nonpungent capsaicin analog, increases endurance swimming capacity of mice by stimulation of vanilloid receptors. Bioscience, Biotechnology, and Biochemistry, 70(4), 774-81.
Haramizu S, et al. Capsiate, a Nonpungent Capsaicin Analog, Increases Endurance Swimming Capacity of Mice By Stimulation of Vanilloid Receptors. Biosci Biotechnol Biochem. 2006;70(4):774-81. PubMed PMID: 16636441.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Capsiate, a nonpungent capsaicin analog, increases endurance swimming capacity of mice by stimulation of vanilloid receptors. AU - Haramizu,Satoshi, AU - Mizunoya,Wataru, AU - Masuda,Yoriko, AU - Ohnuki,Koichiro, AU - Watanabe,Tatsuo, AU - Yazawa,Susumu, AU - Fushiki,Tohru, PY - 2006/4/26/pubmed PY - 2006/6/28/medline PY - 2006/4/26/entrez SP - 774 EP - 81 JF - Bioscience, biotechnology, and biochemistry JO - Biosci Biotechnol Biochem VL - 70 IS - 4 N2 - We investigated the effect of capsiate, a nonpungent natural capsaicin analog, on the swimming capacity of mice in an adjustable-current water pool. Male BALB/c mice orally given capsiate (10 mg/kg) were able to keep swimming longer before exhaustion than the control mice. After 30 min of swimming, the residual glycogen in the gastrocnemius muscle was higher, the serum free fatty acid concentration tended to be higher, and the serum lactic acid concentration was significantly lower in the capsiate-administered mice. The value for the respiratory exchange ratio of the capsiate group was significantly lower during both resting and treadmill running. These physiological differences were abolished by administering the vanilloid receptor antagonist, capsazepin (0.17 mmol/kg, i.p.). The mice were not averse to the capsiate solution during a 4-h two-bottle choice test. These results suggest that the oral administration of capsiate enhanced fat oxidation and spared carbohydrate utilization, and consequently increased the endurance swimming capacity of the mice via stimulation of their vanilloid receptors. Practical application of capsiate is expected. SN - 0916-8451 UR - https://www.unboundmedicine.com/medline/citation/16636441/Capsiate_a_nonpungent_capsaicin_analog_increases_endurance_swimming_capacity_of_mice_by_stimulation_of_vanilloid_receptors_ DB - PRIME DP - Unbound Medicine ER -