Tags

Type your tag names separated by a space and hit enter

Evaluation of the botanical authenticity and phytochemical profile of black cohosh products by high-performance liquid chromatography with selected ion monitoring liquid chromatography-mass spectrometry.
J Agric Food Chem. 2006 May 03; 54(9):3242-53.JA

Abstract

Black cohosh (Actaea racemosa L., syn. Cimicifuga racemosa L.) has become increasingly popular as a dietary supplement in the United States for the treatment of symptoms related to menopause, but the botanical authenticity of most products containing black cohosh has not been evaluated, nor is manufacturing highly regulated in the United States. In this study, 11 black cohosh products were analyzed for triterpene glycosides, phenolic constituents, and formononetin by high-performance liquid chromatography-photodiode array detection and a new selected ion monitoring liquid chromatography-mass spectrometry method. Three of the 11 products were found to contain the marker compound cimifugin and not cimiracemoside C, thereby indicating that these plants contain Asian Actaea instead of black cohosh. One product contained both black cohosh and an Asian Actaea species. For the products containing only black cohosh, there was significant product-to-product variability in the amounts of the selected triterpene glycosides and phenolic constituents, and as expected, no formononetin was detected.

Authors+Show Affiliations

The Richard and Hinda Rosenthal Center for Complementary & Alternative Medicine, Department of Rehabilitation Medicine, College of Physicians & Surgeons, Columbia University, New York, New York 10032, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16637680

Citation

Jiang, Bei, et al. "Evaluation of the Botanical Authenticity and Phytochemical Profile of Black Cohosh Products By High-performance Liquid Chromatography With Selected Ion Monitoring Liquid Chromatography-mass Spectrometry." Journal of Agricultural and Food Chemistry, vol. 54, no. 9, 2006, pp. 3242-53.
Jiang B, Kronenberg F, Nuntanakorn P, et al. Evaluation of the botanical authenticity and phytochemical profile of black cohosh products by high-performance liquid chromatography with selected ion monitoring liquid chromatography-mass spectrometry. J Agric Food Chem. 2006;54(9):3242-53.
Jiang, B., Kronenberg, F., Nuntanakorn, P., Qiu, M. H., & Kennelly, E. J. (2006). Evaluation of the botanical authenticity and phytochemical profile of black cohosh products by high-performance liquid chromatography with selected ion monitoring liquid chromatography-mass spectrometry. Journal of Agricultural and Food Chemistry, 54(9), 3242-53.
Jiang B, et al. Evaluation of the Botanical Authenticity and Phytochemical Profile of Black Cohosh Products By High-performance Liquid Chromatography With Selected Ion Monitoring Liquid Chromatography-mass Spectrometry. J Agric Food Chem. 2006 May 3;54(9):3242-53. PubMed PMID: 16637680.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the botanical authenticity and phytochemical profile of black cohosh products by high-performance liquid chromatography with selected ion monitoring liquid chromatography-mass spectrometry. AU - Jiang,Bei, AU - Kronenberg,Fredi, AU - Nuntanakorn,Paiboon, AU - Qiu,Ming-Hua, AU - Kennelly,Edward J, PY - 2006/4/28/pubmed PY - 2006/6/21/medline PY - 2006/4/28/entrez SP - 3242 EP - 53 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 54 IS - 9 N2 - Black cohosh (Actaea racemosa L., syn. Cimicifuga racemosa L.) has become increasingly popular as a dietary supplement in the United States for the treatment of symptoms related to menopause, but the botanical authenticity of most products containing black cohosh has not been evaluated, nor is manufacturing highly regulated in the United States. In this study, 11 black cohosh products were analyzed for triterpene glycosides, phenolic constituents, and formononetin by high-performance liquid chromatography-photodiode array detection and a new selected ion monitoring liquid chromatography-mass spectrometry method. Three of the 11 products were found to contain the marker compound cimifugin and not cimiracemoside C, thereby indicating that these plants contain Asian Actaea instead of black cohosh. One product contained both black cohosh and an Asian Actaea species. For the products containing only black cohosh, there was significant product-to-product variability in the amounts of the selected triterpene glycosides and phenolic constituents, and as expected, no formononetin was detected. SN - 0021-8561 UR - https://www.unboundmedicine.com/medline/citation/16637680/Evaluation_of_the_botanical_authenticity_and_phytochemical_profile_of_black_cohosh_products_by_high_performance_liquid_chromatography_with_selected_ion_monitoring_liquid_chromatography_mass_spectrometry_ L2 - https://doi.org/10.1021/jf0606149 DB - PRIME DP - Unbound Medicine ER -