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Characteristics of HCV positive subjects referring to hospitals in Italy: a multicentre prevalence study on 6,999 cases.
J Viral Hepat. 2006 May; 13(5):351-4.JV

Abstract

In 2001, 6,999 anti-HCV positive subjects referred to 79 Italian hospital in a 6 months enrollment period were evaluated. Of them, 5,632 (80.5%) tested anti-HCV positive alone, 1,163 (16.6%) reported also an excessive alcohol intake, and 204 (2.9%) were also HBsAg positive. Normal biochemistry was observed in 7.8% of cases, chronic hepatitis in 67.9% of cases, liver cirrhosis in 18.9% of cases, and hepatocellular carcinoma in 3.6% cases. HCV positive subjects with excessive alcohol intake were statistically significantly younger, of male sex, and having more severe liver disease than those without excessive alcohol intake. Adjusting for the confounding effect of age and sex by multiple logistic regression analysis, HCV positive chronic hepatitis cases drinking more than four alcoholic drinks daily were 2.2-fold (CI 95% = 1.3-4.0) more likely to progress to liver cirrhosis than teetotallers. These findings indicate that nearly a quarter of HCV positive subjects referred to hospitals in Italy have a severe liver disease causing a remarkable impact on the national health system. Excessive alcohol intake in HCV chronic hepatitis cases increases the risk of progression to liver cirrhosis.

Authors+Show Affiliations

Clinical Epidemiology Unit, Istituto Superiore di Sanità, Rome, Italy. tommaso.stroffolini@iss.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16637867

Citation

Stroffolini, T, et al. "Characteristics of HCV Positive Subjects Referring to Hospitals in Italy: a Multicentre Prevalence Study On 6,999 Cases." Journal of Viral Hepatitis, vol. 13, no. 5, 2006, pp. 351-4.
Stroffolini T, Sagnelli E, Mariano A, et al. Characteristics of HCV positive subjects referring to hospitals in Italy: a multicentre prevalence study on 6,999 cases. J Viral Hepat. 2006;13(5):351-4.
Stroffolini, T., Sagnelli, E., Mariano, A., Craxí, A., & Almasio, P. (2006). Characteristics of HCV positive subjects referring to hospitals in Italy: a multicentre prevalence study on 6,999 cases. Journal of Viral Hepatitis, 13(5), 351-4.
Stroffolini T, et al. Characteristics of HCV Positive Subjects Referring to Hospitals in Italy: a Multicentre Prevalence Study On 6,999 Cases. J Viral Hepat. 2006;13(5):351-4. PubMed PMID: 16637867.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characteristics of HCV positive subjects referring to hospitals in Italy: a multicentre prevalence study on 6,999 cases. AU - Stroffolini,T, AU - Sagnelli,E, AU - Mariano,A, AU - Craxí,A, AU - Almasio,P, AU - ,, PY - 2006/4/28/pubmed PY - 2006/6/30/medline PY - 2006/4/28/entrez SP - 351 EP - 4 JF - Journal of viral hepatitis JO - J Viral Hepat VL - 13 IS - 5 N2 - In 2001, 6,999 anti-HCV positive subjects referred to 79 Italian hospital in a 6 months enrollment period were evaluated. Of them, 5,632 (80.5%) tested anti-HCV positive alone, 1,163 (16.6%) reported also an excessive alcohol intake, and 204 (2.9%) were also HBsAg positive. Normal biochemistry was observed in 7.8% of cases, chronic hepatitis in 67.9% of cases, liver cirrhosis in 18.9% of cases, and hepatocellular carcinoma in 3.6% cases. HCV positive subjects with excessive alcohol intake were statistically significantly younger, of male sex, and having more severe liver disease than those without excessive alcohol intake. Adjusting for the confounding effect of age and sex by multiple logistic regression analysis, HCV positive chronic hepatitis cases drinking more than four alcoholic drinks daily were 2.2-fold (CI 95% = 1.3-4.0) more likely to progress to liver cirrhosis than teetotallers. These findings indicate that nearly a quarter of HCV positive subjects referred to hospitals in Italy have a severe liver disease causing a remarkable impact on the national health system. Excessive alcohol intake in HCV chronic hepatitis cases increases the risk of progression to liver cirrhosis. SN - 1352-0504 UR - https://www.unboundmedicine.com/medline/citation/16637867/Characteristics_of_HCV_positive_subjects_referring_to_hospitals_in_Italy:_a_multicentre_prevalence_study_on_6999_cases_ L2 - https://doi.org/10.1111/j.1365-2893.2005.00690.x DB - PRIME DP - Unbound Medicine ER -